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Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome

Angiogenic factors are critical to the initiation of angiogenesis and maintenance of the vascular network. Here we use human genetics as an approach to identify an angiogenic factor, VG5Q, and further define two genetic defects of VG5Q in patients...

Authors: Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE,...

Neuron-derived orphan receptor-1 (NOR-1) is induced by thrombin and mediates vascular endothelial cell growth

...of NOR-1 in thrombin-induced endothelial cell growth. RESULTS: Thrombin induced an early and transient up-regulation of NOR-1 in human umbilical vein endothelial cells (HUVEC). NOR-1 up-regulation by thrombin is dependent on multiple pathways, including...

Authors: Martorell L, MartÜnez-GonzÜ¡lez J, Crespo J, Calvayrac O, Badimon L

Angiogenic functionalisation of titanium surfaces using nano-anchored VEGF - an in vitro study

...of human umbilical vein endothelial cells (HUVECs) was significantly increased on the surfaces with specifically bound VEGF compared to the control surfaces and SAE Ti surfaces without VEGF. Moreover, the released conjugated VEGF exhibited biological...

Authors: Schliephake H, Strecker N, Förster A, Schwenzer B, Reichert J, Scharnweber D.

Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type

The identification of organelles is crucial for efficient cellular function, yet the basic underlying mechanisms by which this might occur have not been established. One group of proteins likely to be central to organelle identity is the Rab family...

Authors: Hannah MJ, Hume AN, Arribas M, Williams R, Hewlett LJ, Seabra MC and Cutler DF

New non-viral method for gene transfer into primary cells

The availability of genetically altered cells is an essential prerequisite for many scientific and therapeutic applications including functional genomics, drug development, and gene therapy. Unfortunately, the efficient gene transfer into primary...

Authors: Gresch O, Engel FB, Nesic D, Tran TT, England HM, Hickman ES, Korner I, Gan L, Chen S,...

Supression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB kinase inhibition and cell death induction

The cyclopentenone prostaglandins (cPG) 15-deoxy-Delta12,14-prostaglandin J2 (dPGJ2) and PGA1 can inhibit multiple steps in nuclear factor (NF)-kappaB signaling and can induce cell death. Here we characterized the effects of dPGJ2 and PGA1 on the...

Authors: Zernecke A, Erl W, Fraemohs L, Lietz M and Weber C

ERß-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.

...UtMVECs; myometrium) and human umbilical vein ECs (HUVECs)? SUMMARY ANSWER: Studies conducted in vitro demonstrate that the ERß agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) has EC type-specific effects on patterns of gene expression...

Authors: Greaves E, Collins F, Critchley HO, Saunders PT.

SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo

Successful implantation and long-term survival of engineered tissue grafts hinges on adequate vascularization of the implant. Endothelial cells are essential for patterning vascular structures, but they require supportive mural cells such as...

Authors: Paul JD, Coulombe KL, Toth PT, Zhang Y, Marsboom G, Bindokas VP, Smith DW, Murry CE, Rehman J

Endoglin regulates nitric oxide-dependent vasodilatation

Endoglin is a membrane glycoprotein that plays an important role in cardiovascular development and angiogenesis. We examined the role of endoglin in the control of vascular tone by measuring nitric oxide (NO)-dependent vasodilation in...

Authors: Jerkic M, Rivas-Elena JV, Prieto M, Carron R, Sanz-Rodriguez F, Perez-Barriocanal F,...

Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members

SSphingosine-1-phosphate (S1P), the bioactive product of sphingosine kinase (SK) activation is a survival factor for endothelial cells. The mechanism of SK mediated survival was investigated in endothelial cells with moderately raised intracellular...

Authors: Limaye VS, Li X, Hahn C, Xia P, Berndt MC, Vadas MA and Gamble JR

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