Search Results

PPARa: A Master Regulator of Bilirubin Homeostasis.

...bilirubin synthesis and metabolism. Human umbilical vein epithelial cells (HUVEC) and coronary artery smooth muscle cells (CASMC) were cultured in the absence or presence of the 3 activators, and mRNA, protein, and/or activity levels of the bilirubin...

Authors: Bigo C1, Kaeding J1, El Husseini D1, Rudkowska I2, Verreault M1, Vohl MC3, Barbier O1

Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension.

...hypertrophy in the rat monocrotaline model of experimental pulmonary hypertension. In vitro, thrombin was found to have biphasic effects on key regulators of the nitric oxide-cGMP pathway in endothelial cells (HUVECs). Acute thrombin stimulation led...

Authors: Nickel KF, Laux V, Heumann R, von Degenfeld G.

Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx

...expression, and that LANA inhibited the repression by Daxx in a reporter assay. Analyses of flow cytometry and real-time PCR revealed that expression of VEGF receptor-1 and -2 in LANA-expressing human umbilical vein endothelial cells (HUVECs) significantly...

Authors: Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, Fukazawa H

Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies

...protein-tagged FVIII (FVIII-YFP) and cyan fluorescent protein-tagged VWF (VWF-CFP), we studied intracellular trafficking in human embryonic kidney (HEK293) cells and human umbilical vein endothelial cells (HUVEC). The role of the high-affinity interaction between...

Authors: van den Biggelaar M, Bierings R, Storm G, Voorberg J, Mertens K

Role of Epac1, an Exchange Factor for Rap GTPases, in Endothelial Microtubule Dynamics and Barrier Function

...cell-cell interactions or Rap GTPase activation and was attributed to microtubule growth as assessed by time-lapse microscopy of HUVEC expressing fluorophore-linked microtubule plus-end marker end-binding protein 3. An intact microtubule network was required...

Authors: Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN

TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function

...of cell-cell contact. The junctional localization of TEM4 was independent of actin binding. Depletion of endogenous TEM4 by shRNAs impaired Madin-Darby canine kidney (MDCK) and human umbilical vein endothelial cell (HUVEC) cell junctions, disrupted MDCK acini...

Authors: Ngok SP, Geyer R, Kourtidis A, Mitin N, Feathers R, Der C, Anastasiadis PZ

AILIM/ICOS signaling induces T-cell migration/polarization of memory/effector T-cells

...but also in fibroblast and endothelial cells in various organs. Here, we demonstrate that activated human T-cells migrate beneath TNF-alpha-treated HUVEC and display morphological polarization via AILIM/ICOS signaling. AILIM/ICOS stimulation, in the absence...

Authors: Okamoto N, Nukada Y, Tezuka K, Ohashi K, Mizuno K and Tsuji T

Lymphatic reprogramming of micro vascular endothelial cells by CEA-related Cell Adhesion Molecule-1 via interaction with VEGFR-3 and Prox1

...in FACS analyses while such effects are not observed in CEACAM1 overexpressing HUVECs. This effect of CEACAM1 is ceased when HDMECs are transfected with CEACAM1/y-- missing the tyrosine residues in its cytoplasmic domain. CEACAM1 overexpression in HDMECs...

Authors: Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach JH, Loges S, Kilic E,...

Human endothelial cell-based assay for endotoxin as sensitive as the conventional Limulus Amebocyte Lysate assay

...have used immunofluorescent staining to evaluate the expression of E-selectin on human microvascular endothelial cells from the skin (HDMEC) and human umbilical vein endothelial cells (HUVEC) exposed to various concentrations of LPS. In addition...

Authors: Unger RE, Peters K, Sartoris A, Freese C, Kirkpatrick CJ

Specific growth suppression of human cancer cells by targeted delivery of Dictyostelium mitochondrial ribosomal protein S4

...carcinoma (Caco-2), but not in primary cultured normal cells, such as human brain microvascular endothelial cells (HBMECs); human umbilical vein endothelial cells (HUVECs) and human normal hepatocytes (hHeps™), with one exception (human cardiac fibloblasts...

Authors: Chida J, Araki H, Maeda Y

Data Type

Category

Research Area

Platform

Topic