Jurkat

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HumanT cell leukemia established from the peripheral blood of a 14 year old boy by Schneider et al.

Cell Type:
T Cell
Tissue Origin:
blood
Species:
human
Research Area:
Cancer Research/Cell Biology
Immunotherapy / Hematology
Cell Characteristics:
Suspension

Transfection Information

Lonza Optimized Protocol
Optimization Guideline
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The table below shows data for the cell type and Nucleofector™ Platform selected. Those data are either based on Lonza Optimized Protocols or on results shared from customers who performed an optimization based on our guidelines. In case no data are shown for the selected Nucleofector™ Platform, please take a look at our optimization strategy to get further guidance on how to easily determine optimal Nucleofection conditions yourself.
Protocol Kit Program Cells Efficiency Viable Cells Substrate Format Platform
SE CL-120 2e5 66-76% 76-84% Plasmid (general) 1 µg 20 µl 96-well
SE CL-120 2e5 75.9-77.9% 57-63% Plasmid (general) 0.4 µg 20 µl 4D X-Unit
SE CL-120 1e6 72-74% 69.7-73.7% Plasmid (general) 2 µg 100 µl 4D X-Unit
V X-001 1e6 69-79% 64-84% Plasmid (general) 2 µg 100 µl I/II/2b
V X-001 1e6 87-89% 87-93% Plasmid (general) 2 µg 100 µl I/II/2b
V X-005 1e6 81-87% 64-86% Plasmid (general) 2 µg 100 µl I/II/2b
SE CK-116 2e5 74% ±4 51% ±11 Plasmid (general) 0.4 µg 20 µl 4D X-Unit
SE CK-116 1e6 70% ±5 65% ±11 Plasmid (general) 2 µg 100 µl 4D X-Unit

Citations (98)

Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism
Categories:
Transfection 
Authors:
Sébastien Levesque , Andrea Cosentino,  Archana Verma , Pietro Genovese , Daniel E Bauer  
In:
Nat Biotechnol (2024) :  
The CRISPR-Cas12a Platform for Accurate Genome Editing, Gene Disruption, and Efficient Transgene Integration in Human Immune Cells
Categories:
Transfection, Cell Lines and Primary Cancer Cells 
Authors:
Mohr M, Damas N, Gudmand-Høyer J, Zeeberg K, Jedrzejczyk D, Vlassis A, Morera-Gómez M, Pereira-Schoning S, Puš U, Oliver-Almirall A, Lyholm Jensen T, Baumgartner R, Tate Weinert B, Gill RT, Warnecke T 
In:
ACS Nano (2023) 12(2): 375-389 
A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells
Categories:
Primary Cells and Media, Transfection 
Authors:
Carusillo A, Haider S, Schäfer R, Rhiel M, Türk D, Chmielewski KO, Klermund J, Mosti L, Andrieux G, Schäfer R, Cornu TI, Cathomen T, Mussolino C 
In:
Nucleic Acids Res (2023) 51(9): 4660-4673 
Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells
Categories:
Transfection 
Authors:
Kath J, Du W, Pruene A, Braun T, Thommandru B, Turk R, Sturgeon ML, Kurgan GL, Amini L, Stein M, Zittel T, Martini S, Ostendorf L, Wilhelm A, Akyüz L, Rehm A, Höpken UE, Pruß A, Künkele A, Jacobi AM, Volk HD, Schmueck-Henneresse M, Stripecke R, Reinke P, Wagner DL 
In:
Mol Ther Methods Clin Dev. (2022) 25: 311-330 
CRISPR-Cas12a nucleases function with structurally engineered crRNAs: SynThetic trAcrRNA
Categories:
Primary Cells and Media, Mycoplasma Detection and Prevention, Transfection 
Authors:
Jedrzejczyk DJ, Poulsen LD, Mohr M, Damas ND, Schoffelen S, Barghetti A, Baumgartner R, Weinert BT, Warnecke T, Gill RT 
In:
Biosci Rep (2022) 12(1): 12193 
Optimized design parameters for CRISPR Cas9 and Cas12a homology-directed repair
Categories:
Transfection 
Authors:
Schubert MS, Thommandru B, Woodley J, Turk R, Yan S, Kurgan G, McNeill MS, Rettig GR. 
In:
Scientific Reports (2021) 11(1): 19482 
Successfully Transfected Primary Peripherally Mobilized Human CD34+ Hematopoietic Stem and Progenitor Cells (HSPCs) Demonstrate Increased Susceptibility to Retroviral Infection 
Categories:
Primary Cells and Media, Serum-free and Speciality Media, Transfection 
Authors:
Jeffrey Sebrow , Stephen P Goff, Daniel O Griffin              
In:
Virol J (2020) 17: 1 
CRISPR-targeted display of functional T cell receptors enables 2 engineering of enhanced specificity and prediction of cross-reactivity
Categories:
Transfection 
Authors:
Rodrigo Vazquez-Lombardi, Johanna S. Jung, Florian Bieberich, Edo Kapetanovic, Erik Aznauryan, Cédric R. Weber and Sai T. Reddy 
In:
BioResearch Open Access (2020) :  
TALENs-mediated gene disruption of FLT3 in leukemia cells: Using genome-editing approach for exploring the molecular basis of gene abnormality.
Categories:
Transfection 
Authors:
Wang J, Li T, Zhou M, Hu Z, Zhou X, Zhou S, Wang N, Huang L, Zhao L, Cao Y, Xiao M, Ma D, Zhou P, Shang Z, Zhou J 
In:
Scientific Reports (2015) 5:18454: 10.1038 
High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs.
Categories:
Transfection 
Authors:
Duda K, Lonowski LA, Kofoed-Nielsen M, Ibarra A, Delay CM, Kang Q, Yang Z, Pruett-Miller SM, Bennett EP3, Wandall HH, Davis GD, Hansen SH, Frödin M. 
In:
Nucleic Acids Res (2014) 42: 1-16 
HIV-1 Nef Down-Modulates C-C and C-X-C Chemokine Receptors via Ubiquitin and Ubiquitin-Independent Mechanism
Categories:
Transfection 
Authors:
Prabha Chandrasekaran, Victoria Moore, Monica Buckley, Joshua Spurrier, John H. Kehrl, Sundararajan Venkatesan 
In:
PLoS ONE (2014) 9(1): e86998 
Cancer translocations in human cells induced by zinc finger and TALE nucleases.
Categories:
Transfection 
Authors:
Piganeau M, Ghezraoui H, De Cian A, Guittat L, Tomishima M, Perrouault L, René O, Katibah GE, Zhang L, Holmes MC, Doyon Y, Concordet JP, Giovannangeli C, Jasin M, Brunet E. 
In:
Genome Res (2013) 23(7): 1182-93 
Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1.
Categories:
Primary Cells and Media 
Authors:
Miyamura K, Nishimura Y, Abo M, Wakita T, Shimizu H 
In:
J Gen Virol (2011) 92(Pt2): 287-91 
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media, Transfection 
Authors:
Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X, Li J, Zhou H, Tang Y, Shen N. 
In:
J Immunol (2010) 184(12): 6773-81 
Crosstalk between expression of the HTLV-1 Tax transactivator and the oncogenic bHLH transcription factor TAL1
Categories:
Transfection 
Authors:
Terme JM, Wencker M, Favre-Bonvin A, Bex F, Gazzolo L, Duc Dodon M, Jalinot P 
In:
J Virol (2008) 82(16): 7913-22 
Modulation of T cell activation by stomatin-like protein 2
Categories:
Transfection 
Authors:
Kirchhof MG, Chau LA, Lemke CD, Vardhana S, Darlington PJ, MÜ¡rquez ME, Taylor R, Rizkalla K, Blanca I, Dustin ML, Madrenas J 
In:
J Immunol (2008) 181(3): 1927-36 
Cell type differences in activity of the Streptomyces bacteriophage phi-C31 integrase
Categories:
Transfection 
Authors:
Maucksch C, Aneja MK, Hennen E, Bohla A, Hoffmann F, Elfinger M, Rosenecker J, Rudolph C 
In:
Nucleic Acids Res (2008) epub: online 
Store-dependent and -independent modes regulating CRAC channel activity of human Orai1 and Orai3
Categories:
Transfection 
Authors:
Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD 
In:
J Biol Chem (2008) 283(25): 17662-71 
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor, A443654, in T-Acute Lymphoblastic Leukemia
Categories:
Transfection 
Authors:
Fala F, Blalock WL, Tazzari P, Cappellini A, Chiarini F, Martinelli G, Tafuri A, McCubrey JA, Cocco L, Martelli AM 
In:
Mol Pharmacol (2008) epub: online 
XBP-1, a novel HTLV-1 Tax binding protein, activates HTLV-1 basal and Tax-activated transcription
Categories:
Transfection 
Authors:
Ku SC, Lee J, Lau J, Gurumurthy M, Ng R, Lwa SH, Lee J, Klase Z, Kashanchi F, Chao SH 
In:
J Virol (2008) 82(9): 4343-53 
Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70
Categories:
Transfection 
Authors:
Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL, Pannen BH, Loop T 
In:
J Pharmacol Exp Ther (2008) 325(1): 217-25 
Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission
Categories:
Transfection 
Authors:
Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM 
In:
Nat Cell Biol (2008) 10(2): 211-9 
Cyclin-dependent kinase inhibitors block leukocyte adhesion and migration
Categories:
Transfection 
Authors:
Liu L, Schwartz B, Tsubota Y, Raines E, Kiyokawa H, Yonekawa K, Harlan JM, Schnapp LM 
In:
J Immunol (2008) 180(3): 1808-17 
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation
Categories:
Transfection 
Authors:
Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D, Roos J, Stauderman KA, Cahalan MD 
In:
Proc Natl Acad Sci USA (2008) 105(6): 2011-6 
Drp1 mediates caspase-independent type III cell death in normal and leukemic cells
Categories:
Transfection 
Authors:
Bras M, Yuste VJ, Roué G, Barbier S, Sancho P, Virely C, Rubio M, Baudet S, Esquerda JE, Merle-Béral H, Sarfati M, Susin SA 
In:
Mol Cell Biol (2007) 27(20): 7073-88 
Negative regulation of the SH2-homology-containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 tax oncoprotein
Categories:
Transfection 
Authors:
Cheng J, Kydd AR, Nakase K, Noonan KM, Murakami A, Tao H, Dwyer M, Xu C, Zhu Q, Marasco WA 
In:
Blood (2007) 110(6): 2110-20 
Pivotal Advance: Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells
Categories:
Transfection 
Authors:
Prasad A, Qamri Z, Wu J, Ganju RK 
In:
J Leukoc Biol (2007) 82(3): 465-76 
In Vivo and in Vitro Intragenomic Rearrangement of TT Viruses
Categories:
Transfection 
Authors:
Leppik L, Gunst K, Lehtinen M, Dillner J, Streker K, de Villiers EM 
In:
J Virol (2007) 81(17): 9346-56 
T Cells Express 7-Nicotinic Acetylcholine Receptor Subunits That Require a Functional TCR and Leukocyte-Specific Protein Tyrosine Kinase for Nicotine-Induced Ca2+ Response
Categories:
Transfection 
Authors:
Razani-Boroujerdi S, Boyd RT, DÜ¡vila-GarcÜ­a MI, Nandi JS, Mishra NC, Singh SP, Pena-Philippides JC, Langley R, Sopori ML 
In:
J Immunol (2007) 179(5): 2889-98 
Vif counteracts a cyclophilin A-imposed inhibition of Simian immunodeficiency viruses in human cells
Categories:
Transfection 
Authors:
Takeuchi H, Buckler-White A, Goila-Gaur R, Miyagi E, Khan MA, Opi S, Kao S, Sokolskaja E, Pertel T, Luban J, Strebel K 
In:
J Virol (2007) 81(15): 8080-90 
Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase
Categories:
Transfection 
Authors:
Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, Shimoda K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T 
In:
J Immunol (2007) 179(4): 2397-407 
CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function
Categories:
Transfection 
Authors:
Giri B, Dixit VD, Ghosh MC, Collins GD, Khan IU, Madara K, Weeraratna AT, Taub DD 
In:
Eur J Immunol (2007) 37(8): 2104-16 
Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells
Categories:
Transfection 
Authors:
Mitchell DA, Morton SU, Fernhoff NB, Marletta MA 
In:
Proc Natl Acad Sci USA (2007) 104(28): 11609-14 
The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2
Categories:
Transfection 
Authors:
Mor A, Campi G, Du G, Zheng Y, Foster DA, Dustin ML, Philips MR 
In:
Nat Cell Biol (2007) 9(6): 713-9 
Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells
Categories:
Transfection 
Authors:
Grabarczyk P, Przybylski GK, Depke M, Volker U, Bahr J, Assmus K, Broker BM, Walther R, Schmidt CA 
In:
Oncogene (2007) 26(26): 3797-810 
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Categories:
Transfection 
Authors:
Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Fingerle-Rowson G, Ghezzi P, Kleemann R, McColl SR, Bucala R, Hickey MJ, Weber C 
In:
Nat Med (2007) 13(5): 587-596 
Down-Regulation of IL-7R Expression in Human T Cells via DNA Methylation
Categories:
Transfection 
Authors:
Kim HR, Hwang KA, Kim KC, Kang I 
In:
J Immunol (2007) 178(9): 5473-9 
Requirement for Daxx in mature T-cell proliferation and activation
Categories:
Transfection 
Authors:
Leal-Sanchez J, Couzinet A, Rossin A, Abdel-Sater F, Chakrabandhu K, Luci C, Anjuere F, Stebe E, Hancock D, Hueber AO 
In:
Cell Death Differ (2007) 14(4): 795-806 
Physiologically high concentrations of 17-beta-estradiol enhance NF-kappaB activity in human T cells
Categories:
Transfection 
Authors:
Hirano S, Furutama D, Hanafusa T 
In:
Am J Physiol Regul Integr Comp Physiol (2007) 292(4): R1465-71 
Bcl10 Controls TCR- and FcR-Induced Actin Polymerization
Categories:
Transfection 
Authors:
Rueda D, Gaide O, Ho L, Lewkowicz E, Niedergang F, Hailfinger S, Rebeaud F, Guzzardi M, Conne B, Thelen M, Delon J, Ferch U, Mak TW, Ruland J, Schwaller J, Thome M 
In:
J Immunol (2007) 178(7): 4373-84 
IFN-alpha-Induced Signal Transduction, Gene Expression, and Antitumor Activity of Immune Effector Cells Are Negatively Regulated by Suppressor of Cytokine Signaling Proteins
Categories:
Transfection 
Authors:
Zimmerer JM, Lesinski GB, Kondadasula SV, Karpa VI, Lehman A, Raychaudhury A, Becknell B, Carson WE 3rd 
In:
J Immunol (2007) 178(8): 4832-45 
ZAP-70 enhances B-cell receptor signaling in spite of absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B-cells
Categories:
Transfection 
Authors:
Gobessi S, Laurenti L, Longo PG, Sica S, Leone G, Efremov DG 
In:
Blood (2007) 109(5): 2032-9 
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1
Categories:
Transfection 
Authors:
Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C 
In:
J Biol Chem (2007) 282(13): 10117-31 
Suppression of microRNA-silencing pathway by HIV-1 during virus replication
Categories:
Transfection 
Authors:
Triboulet R, Mari B, Lin YL, Chable-Bessia C, Bennasser Y, Lebrigand K, Cardinaud B, Maurin T, Barbry P, Baillat V, Reynes J, Corbeau P, Jeang KT, Benkirane M 
In:
Science (2007) 315(5818): 1579-82 
The inner loop of tetraspanins CD82 and CD81 mediates interactions with HTLV-1 gag protein
Categories:
Transfection 
Authors:
Mazurov D, Heidecker G, Derse D 
In:
J Biol Chem (2007) 282(6): 3896-903 
A functional SNP of interferon- gene is important for interferon--induced and spontaneous recovery from hepatitis C virus infection
Categories:
Transfection 
Authors:
Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, Thio CL, Thomas DL, Alter HJ, Sapp RK, Liang TJ 
In:
Proc Natl Acad Sci USA (2007) 104(3): 985-90 
Nef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation
Categories:
Transfection 
Authors:
Crotti A, Neri F, Corti D, Ghezzi S, Heltai S, Baur A, Poli G, Santagostino E, Vicenzi E 
In:
J Virol (2006) 80(21): 10663-74 
The marine product cephalostatin 1 activates an ER stress-specific and apoptosome-independent apoptotic signaling pathway
Categories:
Transfection 
Authors:
Lopez-Anton N, Rudy A, Barth N, Schmitz ML, Pettit GR, Schulze-Osthoff K, Dirsch VM, Vollmar AM 
In:
J Biol Chem (2006) 281(44): 33078-86 
CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse
Categories:
Transfection 
Authors:
Tavano R, Contento RL, Baranda SJ, Soligo M, Tuosto L, Manes S, Viola A 
In:
Nat Cell Biol (2006) 8(11): 1270-6 
A Single Polymorphism Disrupts the Killer Ig-Like Receptor 2DL2/2DL3 D1 Domain
Categories:
Transfection 
Authors:
Vandenbussche CJ, Dakshanamurthy S, Posch PE, Hurley CK 
In:
J Immunol (2006) 177(8): 5347-57 
The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis
Categories:
Transfection 
Authors:
Thurau M, Everett H, Tapernoux M, Tschopp J, Thome M 
In:
Cell Death Differ (2006) 13(9): 1577-85 
Apoptotic cells promote macrophage survival by releasing the anti-apoptotic mediator sphingosine-1-phosphate
Categories:
Transfection 
Authors:
Weigert A, Johann AM, von Knethen A, Schmidt H, Geisslinger G, Brune B 
In:
Blood (2006) 108(5): 1635-42 
The mTOR pathway regulates mitochondrial oxygen consumption and oxidative capacity
Categories:
Transfection 
Authors:
Schieke SM, Phillips D, McCoy JP Jr, Aponte AM, Shen RF, Balaban RS, Finkel T 
In:
J Biol Chem (2006) 281(37): 27643-52 
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
Categories:
Transfection 
Authors:
Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE 
In:
Nat Struct Mol Biol (2006) 13(9): 798-805 
A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population
Categories:
Transfection 
Authors:
Ozaki K, Sato H, Iida A, Mizuno H, Nakamura T, Miyamoto Y, Takahashi A, Tsunoda T, Ikegawa S, Kamatani N, Hori M, Nakamura Y, Tanaka T 
In:
Nat Genet (2006) 38(8): 921-5 
9-tetrahydrocannabinol-induced apoptosis in jurkat leukemia T cells is regulated by translocation of bad to mitochondria
Categories:
Transfection 
Authors:
Jia W, Hegde VL, Singh NP, Sisco D, Grant S, Nagarkatti M, Nagarkatti PS 
In:
Mol Cancer Res (2006) 4(8): 549-62 
The SWI/SNF chromatin-remodeling complex is a cofactor for tat transactivation of the HIV promoter
Categories:
Transfection 
Authors:
Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E 
In:
J Biol Chem (2006) 281(29): 19960-8 
Cell Adhesion Regulates CDC25A Expression and Proliferation in Acute Myeloid Leukemia
Categories:
Transfection 
Authors:
Fernandez-Vidal A, Ysebaert L, Didier C, Betous R, De Toni F, Prade-Houdellier N, Demur C, Contour-Galcera MO, Prevost GP, Ducommun B, Payrastre B, Racaud-Sultan C, Manenti S 
In:
Cancer Res (2006) 66(14): 7128-35 
Identification of a novel mutation of SH3BP2 in cherubism and demonstration that SH3BP2 mutations lead to increased NFAT activation
Categories:
Transfection 
Authors:
Lietman SA, Kalinchinko N, Deng X, Kohanski R, Levine MA 
In:
Hum Mutat (2006) 27(7): 717-8 
Identification of an Intracellular Trafficking and Assembly Pathway for HIV-1 Gag
Categories:
Transfection 
Authors:
Perlman M, Resh MD 
In:
Traffic (2006) 7(6): 731-45 
Protein Kinase C (PKC) and PKC Are the Major PKC Isotypes Involved in TCR Down-Regulation
Categories:
Transfection 
Authors:
von Essen M, Nielsen MW, Bonefeld CM, Boding L, Larsen JM, Leitges M, Baier G, Odum N, Geisler C 
In:
J Immunol (2006) 176(12): 7502-10 
HTLV-1 tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)
Categories:
Transfection 
Authors:
Krueger A, Fas SC, Giaisi M, Bleumink M, Merling A, Stumpf C, Baumann S, Holtkotte D, Bosch V, Krammer PH and Li-Weber M 
In:
Blood (2006) 107(10): 3933-9 
HIV-1 GP120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase, CD45
Categories:
Transfection 
Authors:
Anand AR, Ganju RK 
In:
J Biol Chem (2006) 281(18): 12289-99 
Transcriptional repression of human immunodeficiency virus type 1 by AP-4
Categories:
Transfection 
Authors:
Imai K, Okamoto T 
In:
J Biol Chem (2006) 281(18): 12495-505 
Loss of Siglec expression on T lymphocytes during human evolution
Categories:
Transfection 
Authors:
Nguyen DH, Hurtado-Ziola N, Gagneux P, Varki A 
In:
Proc Natl Acad Sci USA (2006) 103(20): 7765-70 
Long-term engagement of CD6 and ALCAM is essential for T cell proliferation induced by dendritic cells
Categories:
Transfection 
Authors:
Zimmerman AW, Joosten B, Torensma R, Parnes JR, van Leeuwen FN and Figdor CG 
In:
Blood (2006) 107(8): 3212-20 
A Novel NF-B Binding Site Controls Human Granzyme B Gene Transcription
Categories:
Transfection 
Authors:
Huang C, Bi E, Hu Y, Deng W, Tian Z, Dong C, Hu Y, Sun B 
In:
J Immunol (2006) 176(7): 4173-81 
The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse
Categories:
Transfection 
Authors:
Lettau M, Qian J, Linkermann A, Latreille M, Larose L, Kabelitz D, Janssen O 
In:
Proc Natl Acad Sci USA (2006) 103(15): 5911-6 
Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems
Categories:
Transfection 
Authors:
Plant EP, Dinman JD 
In:
RNA (2006) 12(4): 666-73 
The PDZ binding motif of HTLV-1 tax promotes virus mediated T-cell proliferation in vitro and persistence in vivo
Categories:
Transfection 
Authors:
Xie L, Yamamoto B, Haoudi A, Semmes OJ and Green PL 
In:
Blood (2006) 107(5): 1980-8 
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
Categories:
Transfection 
Authors:
Booth AM, Fang Y, Fallon JK, Yang JM, Hildreth JE, Gould SJ 
In:
J Cell Biol (2006) 172(6): 923-35 
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
Categories:
Transfection 
Authors:
Weinberg MS, Villeneuve LM, Ehsani A, Amarzguioui M, Aagaard L, Chen ZX, Riggs AD, Rossi JJ and Morris KV 
In:
RNA (2006) 12(2): 256-262 
The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1
Categories:
Transfection 
Authors:
Muthumani K, Choo AY, Zong WX, Madesh M, Hwang DS, Premkumar A, Thieu KP, Emmanuel J, Kumar S, Thompson CB, Weiner DB 
In:
Nat Cell Biol (2006) 8(2): 170-9 
The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
Categories:
Transfection 
Authors:
Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E and Colomer D 
In:
Blood (2006) 107(1): 257-264 
The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B
Categories:
Transfection 
Authors:
Lieto LD, Maasho K, West D, Borrego F and Coligan JE 
In:
Genes Immun (2006) 7(1): 36-43 
Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling
Categories:
Transfection 
Authors:
Zipfel PA, Bunnell SC, Witherow DS, Gu JJ, Chislock EM, Ring C, Pendergast AM 
In:
Curr Biol (2006) 16(1): 35-46 
A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death
Categories:
Transfection 
Authors:
Guo Y, Chen C, Zheng Y, Zhang J, Tao X, Liu S, Zheng D and Liu Y 
In:
J Biol Chem (2005) 280(51): 41940-41952 
Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain a and B
Categories:
Transfection 
Authors:
Skov S, Pedersen MT, Andresen L, Thor Straten P, Woetmann A and Odum N 
In:
Cancer Res (2005) 65(23): 11136-11145 
Phosphorylation of the CARMA1 linker controls NF-kappaB activation
Categories:
Transfection 
Authors:
Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-Garcia ME, Ovechkina YL, Rawlings DJ 
In:
Immunity (2005) 23(6): 561-74 
STIM1 is a Ca(2+) sensor that activates CRAC channels and migrates from the Ca(2+) store to the plasma membrane
Categories:
Transfection 
Authors:
Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA and Cahalan MD 
In:
Nature (2005) 437(7060): 902-905 
NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor
Categories:
Transfection 
Authors:
Dreikhausen U, Hiebenthal-Millow K, Bartels M, Resch K and Nourbakhsh M 
In:
Mol Cell Biol (2005) 25(17): 7473-7483 
Human T-lymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse
Categories:
Transfection 
Authors:
Nejmeddine M, Barnard AL, Tanaka Y, Taylor GP and Bangham CR 
In:
J Biol Chem (2005) 280(33): 29653-29660 
Human T-Lymphotropic Virus Type 1 Mitochondrion-Localizing Protein p13II Sensitizes Jurkat T Cells to Ras-Mediated Apoptosis
Categories:
Transfection 
Authors:
Hiraragi H, Michael B, Nair A, Silic-Benussi M, Ciminale V and Lairmore M 
In:
J Virol (2005) 79(15): 9449-9457 
An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity
Categories:
Transfection 
Authors:
Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, Mirkovic D, Nguyen J, Wang H, Yang XF 
In:
Oncogene (2005) 24(30): 4778-4788 
Spatial and functional heterogeneity of sphingolipid-rich membrane domains
Categories:
Transfection 
Authors:
Kiyokawa E, Baba T, Otsuka N, Makino A, Ohno S and Kobayashi T 
In:
J Biol Chem (2005) 280(25): 24072-24084 
CUL1, a component of E3 ubiquitin ligase, alters lymphocyte signal transduction with possible effect on rheumatoid arthritis
Categories:
Transfection 
Authors:
Kawaida R, Yamada R, Kobayashi K, Tokuhiro S, Suzuki A, Kochi Y, Chang X, Sekine A, Tsunoda T, Sawada T, Furukawa H, Nakamura Y and Yamamoto K 
In:
Genes Immun (2005) 6(3): 194-202 
Identification of proteoglycans as the APRIL-specific binding partners
Categories:
Transfection 
Authors:
Ingold K, Zumsteg A, Tardivel A, Huard B, Steiner QG, Cachero TG, Qiang F, Gorelik L, Kalled SL, Acha-Orbea H, Rennert PD, Tschopp J, Schneider P 
In:
J Exp Med (2005) 201(9): 1375-1383 
EBV-Induced Gene 3 Transcription Is Induced by TLR Signaling in Primary Dendritic Cells via NF-(kappa)B Activation
Categories:
Transfection 
Authors:
Wirtz S, Becker C, Fantini MC, Nieuwenhuis EE, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS and Neurath MF 
In:
J Immunol (2005) 174(5): 2814-2824 
Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity
Categories:
Transfection 
Authors:
Gaikwad A, Poblenz A, Haridas V, Zhang C, Duvic M and Gutterman J 
In:
Clin Cancer Res (2005) 11(5): 1953-1962 
Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway
Categories:
Transfection 
Authors:
Song EJ, Yim SH, Kim E, Kim NS and Lee KJ 
In:
Mol Cell Biol (2005) 25(6): 2511-2524 
Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for binding to DC-SIGN
Categories:
Transfection 
Authors:
Puissant B, Roubinet F, Dellacasagrande J, Massip P, Abbal M, Pasquier C, Izopet J, Blancher A 
In:
AIDS (2005) 19(6): 627-30 
Unexpected side chain effects at residue 8 of cyclosporin a derivatives allow photoswitching of immunosuppression
Categories:
Transfection 
Authors:
Zhang Y, Erdmann F, Baumgrass R, Schutkowski M and Fischer G 
In:
J Biol Chem (2005) 280(6): 4842-4850 
Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton
Categories:
Transfection 
Authors:
Dombroski D, Houghtling RA, Labno CM, Precht P, Takesono A, Caplen NJ, Billadeau DD, Wange RL, Burkhardt JK and Schwartzberg PL 
In:
J Immunol (2005) 174(3): 1385-1392 
PTEN regulates motility but not directionality during leukocyte chemotaxis
Categories:
Transfection 
Authors:
Lacalle RA, Gomez-Mouton C, Barber DF, Jimenez-Baranda S, Mira E, Martinez-A C, Carrera AC, Manes S 
In:
J Cell Sci (2004) 117(Pt 25): 6207-6215 
Nicotine Activates Nuclear Factor of Activated T Cells c2 (NFATc2) and Prevents Cell Cycle Entry in T Cells
Categories:
Transfection 
Authors:
Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D and Modiano JF 
In:
J Pharmacol Exp Ther (2004) 311(2): 758-769 
Mechanism of prostaglandin (PG)E2-induced prolactin expression in human T cells: cooperation of two PGE2 receptor subtypes, E-prostanoid (EP) 3 and EP4, via calcium- and cyclic adenosine 5'-monophosphate-mediated signaling pathways
Categories:
Transfection 
Authors:
Gerlo S, Verdood P, Gellersen B, Hooghe-Peters EL and Kooijman R 
In:
J Immunol (2004) 173(10): 5952-5962 
Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
James CO, Huang MB, Khan M, Garcia-Barrio M, Powell MD, Bond VC 
In:
J Virol (2004) 78(6): 3099-109 
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.
Categories:
Transfection 
Authors:
Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA and Samelson LE 
In:
J Cell Biol (2002) 158(7): 1263-1275 
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