Search Results

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

BACKGROUND: p21-activated kinase 1 (Pak1) phosphorylates many proteins in both normal and transformed cells. Its ability to phosphorylate and thereby activate the estrogen receptor alpha (ERalpha) potentially limits the effectiveness of antiestrogen...

Authors: Holm C, Rayala S, Jirstrom K, Stal O, Kumar R, Landberg G

The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression

The IR2 protein (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich tract and yet retaining binding domains for DNA and TFIIB and nuclear localization...

Authors: Kim SK, Ahn BC, Albrecht RA, O'callaghan DJ

Peroxisome Proliferator-Activated Receptor Activation Decreases Metastatic Potential of Melanoma Cells In vitro via Down-Regulation of Akt

PURPOSE: Peroxisome proliferator-activated receptors (PPAR) regulate lipid and glucose metabolism but their anticancer properties have been recently studied as well. We previously reported the antimetastatic activity of the PPARalpha ligand,...

Authors: Grabacka M, Plonka PM, Urbanska K, Reiss K

Transcriptional Regulation of Lung Cytidylyltransferase in Developing Transgenic Mice

Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant...

Authors: McCoy DM, Fisher K, Robichaud J, Ryan AJ, Mallampalli RK

Glucocorticoid hormones decrease proliferation of embryonic neural stem cells through ubiquitin-mediated degradation of cyclin D1

Corticosteroids can influence brain function, and glucocorticoid hormone receptors (GRs) are present in brain tissue. We observed that GR and also mineralocorticoid receptor (MR) are expressed by embryonic rat neural stem cells (NSCs). NSCs in...

Authors: Sundberg M, Savola S, Hienola A, Korhonen L, Lindholm D

Cytoplasmic IRE1alpha -mediated XBP1 mRNA splicing in the absence of nuclear processing and ER stress

Accumulation of unfolded proteins in the endoplasmic reticulum activates an intracellular signal transduction program termed the Unfolded Protein Response (UPR). In mammalian cells, the UPR is signaled in part through dimerization of ER...

Authors: Back SH, Lee K, Vink E, Kaufman RJ

Specific recognition of apoptotic cells reveals a ubiquitous and unconventional innate immunity

The purpose of physiological cell death is the non-inflammatory clearance of cells that have become inappropriate or non-functional. Consistent with this function, the recognition of apoptotic cells by professional phagocytes, including macrophages...

Authors: Cvetanovic M, Mitchell JE, Patel V, Avner BS, Su Y, van der Saag PT, Witte PL, Fiore S, Levine JS,...

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

The biologic hallmark of polycythemia vera (PV) is the formation of endogenous erythroid colonies (EECs) with an erythropoietin-independent differentiation. Recently, it has been shown that an activating mutation of JAK2 (V617F) was at the origin of...

Authors: Garcon L, Rivat C, James C, Lacout C, Camara-Clayette V, Ugo V, Lecluse Y, Bennaceur-Griscelli A,...

Nuclear localization in the biology of the CD40 receptor in normal and neoplastic human B lymphocytes

CD40 is a TNF receptor superfamily (TNRSF-5) member that initiates important signaling pathways mediating cell growth, survival and differentiation in B-lymphocytes. Although CD40 has been extensively studied as a plasma membrane-associated growth...

Authors: Lin-Lee YC, Pham LV, Tamayo AT, Fu L, Zhou HJ, Yoshimura LC, Decker GL, Ford RJ

Molecular and Functional Analyses of a Human Parvovirus B19 Infectious Clone Demonstrates Essential Roles for NS1, VP1, and the 11-Kilodalton Protein in Virus Replication and Infectivity

In an attempt to experimentally define the roles of viral proteins encoded by the B19 genome in the viral life cycle, we utilized the B19 infectious clone constructed in our previous study to create two groups of B19 mutant genomes: (i) null mutants,...

Authors: Zhi N, Mills IP, Lu J, Wong S, Filippone C, Brown KE

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