Hepatocyte Maintenance Medium

HMM is a serum-free medium that may be used to maintain fresh plated human and animal hepatocytes in culture during testing.

Shelf Life:
12 months
Recommended for Cells:
Hepatocyte, mouse ; Hepatocyte, rat ; Hepatocyte, human ; Hepatocyte, Cynomolgus ; Hepatocyte, Rhesus
Categories:
Primary Cells and Media
Research Areas:
Toxicology

Citations (15)

Protocol to create phenotypic primary human hepatocyte cultures using the RASTRUM 3D cell model platform
Categories:
Primary Cells and Media, 3D Cell Culture , Serum-free and Speciality Media 
Authors:
Christine Yee , Yik Lung Chan , Robert Utama , Marie Besnier , Martin Engel , Lisa Belfiore  
In:
STAR Protoc (2024) 5: 103234 
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
Categories:
 
Authors:
Efren Garcia-Maldonado , Andrew D Huber , Sergio C Chai , Stanley Nithianantham , Yongtao Li , Jing Wu , Shyaron Poudel , Darcie J Miller , Jayaraman Seetharaman , Taosheng Chen  
In:
Nature (2024) 15: 4054 
Establishment of a cell culture platform for human liver organoids and its application for lipid metabolism research
Categories:
Primary Cells and Media, 3D Cell Culture  
Authors:
Ayane Kuboyama-Sasaki , Yu Takahashi , Chen Xia , Kahori Hiro , Tsuyoshi Kobayashi , Hideki Ohdan , Makoto Shimizu , Yoshio Yamauchi , Hiroshi Kiyono , Ryuichiro Sato  
In:
Biotechnology Journal (2024) 19: 1 
Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers
Categories:
Primary Cells and Media 
Authors:
Xiao Liu , Kevin Lam , Huayi Zhao , Sadatsugu Sakane , Hyun Young Kim , Alvaro Eguileor , Karin Diggle , Shuai Wu , Raquel Carvalho Gontijo Weber , Pejman Soroosh , Mojgan Hosseini , Kristin Mekeel , David A Brenner , Tatiana Kisseleva  
In:
STAR Protoc (2023) 4: 3 
Electroporation-mediated Delivery of Cas9Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes
Categories:
Transfection 
Authors:
Tanner Rathbone , Ilayda Ates , Lawrence Fernando , Ethan Addlestone , Ciaran M Lee , Vincent P Richards , Renee N Cottle de  
In:
CRISPR J (2022) :  
Application of in- vitro-cultured primary hepatocytes to evaluate species translatability and AAV transduction mechanisms of action
Categories:
Primary Cells and Media 
Authors:
Su Liu , Lisa Razon , Olivia Ritchie , Choong-Ryoul Sihn , Britta Handyside , Geoffrey Berguig , Jill Woloszynek , Lening Zhang , Paul Batty , David Lillicrap , Vishal Agrawal , Christa Cortesio , Kahsay Gebretsadik , Hassibullah Akeefe , Peter Colosi , Benjamin Kim , Stuart Bunting , Sylvia Fong  
In:
Mol Ther Methods Clin Dev. (2022) 26: 61-71 
Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells
Categories:
Primary Cells and Media 
Authors:
Rong Li , Yang Zhao , Jeffrey J Yourick , Robert L Sprando , Xiugong Gao  
In:
Biomed Res Int. (2022) 16: 43 
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes showing heterogeneous responses to drug challenge
Categories:
Primary Cells and Media, Serum-free and Speciality Media 
Authors:
E. Sanchez-Quant, M. L. Richter, M. Colomé-Tatché , C.P. Martinez-Jimenez 
In:
BioResearch Open Access (2020) 0: 0 
Modulation of hepatitis B virus infection by epidermal growth factor secreted from liver sinusoidal endothelial cells
Categories:
Primary Cells and Media, Serum-free and Speciality Media, Cell Lines and Primary Cancer Cells 
Authors:
Shin-Wei C hen, Misao Himeno, Yuta Koui, Masaya Sugiyama, Hironori Nishitsuji, Masashi Mizokami, Kunitada Shimotohno, Atsushi Miyajima & Taketomo Kido 
In:
Scientific Reports (2020) 10: 14349 
Genome-wide binding and transcriptome analysis of human farnesoid x receptor in primary human hepatocytes
Categories:
Primary Cells and Media 
Authors:
Zhan L, Liu HX, Fang Y, Kong B, He Y, Zhong XB, Fang J, Wan YJ, Guo GL. 
In:
PLoS ONE (2014) 9(9): e105930 
The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ma B, Wells A. 
In:
J Biol Chem (2014) 289(16): 11153-61 
Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Rodriguez R1, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. 
In:
Infect Immun (2014) 82(2): 745-52 
Elaidate, an 18-carbon trans-monoenoic fatty acid, inhibits ß-oxidation in human peripheral blood macrophages
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Zacherl JR, Mihalik SJ, Chace DH, Christensen TC, Robinson LJ, Blair HC. 
In:
J Cell Biol (2014) 115(1): 62-70 
Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y. 
In:
Hepatology (2013) 57(5): 1992-2003 
Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.
Categories:
Primary Cells and Media 
Authors:
Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S 
In:
PLoS ONE (2011) 6(12): e28714 
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