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PyroTec Pro: Has any stability testing been performed for the endotoxin and lysate that stay on the instrument before use?

Our data indicate that the reagents should be placed on the deck prior to running the automated assay. This would be similar to the methodology when performing the assay on the bench. Customers should follow procedures similar to those in a manual...

PyroTec Pro: How long does the assay take, and can an assay be run overnight?

Typical runtime from start of the automated microplate setup to completion of WinKQCL™ Software reading the plate for a single assay is 1.5 hours – 2.5 hours, depending on the number of samples and the complexity of the dilutions. Therefore, a...

How long does it take to perform the PyroTec Pro installation, operational and performance (IOPQ)?

There are many components that need to be installed and validated. Depending on the customizations needed, estimated time for installation and operational qualification is one week.

Does the reported Log4j vulnerability threat affect our WinKQCL software (Catalog # 25-611E)?

Thank you for using Lonza Endotoxin Detection Products.Lonza has been providing endotoxin detection products and services since the 1970s, leading the way in innovation of products, methods and software.Our dedicated WinKQCL software is on the market...

The effect of chitin size, shape, source and purification method on immune recognition.

The animal immune response to chitin is not well understood and needs to be investigated further. However, this is a challenging topic to study because of the technical difficulties in purifying chitin, and because this material usually comes...

Authors: Alvarez FJ.

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

Chitin is an essential structural polysaccharide of fungal pathogens and parasites, but its role in human immune responses remains largely unknown. It is the second most abundant polysaccharide in nature after cellulose and its derivatives today are...

Authors: Wagener J1, Malireddi RK2, Lenardon MD1, Köberle M3, Vautier S1, MacCallum DM1, Biedermann T3,...

Endotoxin-induced monocytic microparticles have contrasting effects on endothelial inflammatory responses.

Septic shock is a severe disease state characterised by the body's life threatening response to infection. Complex interactions between endothelial cells and circulating monocytes are responsible for microvasculature dysfunction contributing to the...

Authors: Wen B, Combes V, Bonhoure A, Weksler BB, Couraud PO, Grau GE.

Human endothelial cell-based assay for endotoxin as sensitive as the conventional Limulus Amebocyte Lysate assay

Endotoxin, also known as lipopolysaccharide (LPS) produced by bacteria can be present in any liquid or on any biomaterial even if the material is sterile. Endotoxin in mammals can cause fever, inflammation, cell and tissue damage and irreversible...

Authors: Unger RE, Peters K, Sartoris A, Freese C, Kirkpatrick CJ

Analysis of wear, wear particles, and reduced inflammatory potential of vitamin E ultrahigh-molecular-weight polyethylene for use in total joint replacement.

Vitamin E (VE) has been added to ultrahigh-molecular-weight polyethylene (UHMWPE) acetabular cups and tibial trays primarily to reduce oxidative damage to the polymer. The aim of this study was to investigate the relative wear rates of...

Authors: Bladen CL1, Teramura S, Russell SL, Fujiwara K, Fisher J, Ingham E, Tomita N, Tipper JL.

HBD3 regulates matrix metalloproteinase production in human myeloid dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B

Matrix metalloproteinases (MMP) are zinc- or calcium-dependent proteinases involved in the normal maintenance of the extracellular matrix. When elevated, MMPs degrade matrix components contributing to tissue destruction in infected periodontal sites....

Authors: Raina M

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