Search Results

FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway

FK506 binding protein 5 (FKBP5) belongs to a family of immunophilins named for their ability to bind immunosuppressive drugs, also known as peptidyl-prolyl cis-trans isomerases, and also with chaperones to help protein folding. Using glioma cDNA...

Authors: Jiang W, Cazacu S, Xiang C, Zenklusen JC, Fine HA, Berens M, Armstrong B, Brodie C, Mikkelsen T

Survival signaling by C-RAF: mitochondrial ROS and Ca2+ are critical targets

Survival signaling by RAF occurs through largely unknown mechanisms. Here we provide evidence for the first time that RAF controls cell survival by maintaining permissive levels of mitochondrial reactive oxygen species (ROS) and Ca(2+). IL-3...

Authors: Kuznetsov AV, Smigelskaite J, Doblander C, Janakiraman M, Hermann M, Wurm M, Scheidl S, Sucher R,...

CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells

High CD30 expression in classical Hodgkin's lymphoma and anaplastic large cell lymphoma (ALCL) suggests an important pathogenic role of this cytokine receptor. To test this hypothesis, we investigated CD30 signaling in Hodgkin's and ALCL cell lines...

Authors: Hirsch B, Hummel M, Bentink S, Fouladi F, Spang R, Zollinger R, Stein H, Dürkop H

SST Peer Reviewed

Phosphorylation of LXR alpha Selectively Regulates Target Gene Expression in Macrophages

Dysregulation of LXRalpha activity has been linked to cardiovascular and metabolic diseases. Here, we show that LXRalpha target gene selectivity is achieved by modulation of LXRalpha phosphorylation. Under basal conditions, LXRalpha is phosphorylated...

Authors: Torra IP, Ismaili N, Feig JE, Xu CF, Cavasotto C, Pancratov R, Rogatsky I, Neubert TA, Fisher EA,...

Critical role for transcription factor C/EBP-beta in regulating the expression of death-associated protein kinase 1

Transcription factor C/EBP-beta regulates a number of physiologic responses. During an investigation of the growth-suppressive effects of IFNs, we noticed that cebpb (-/-) cells fail to undergo apoptosis upon IFN-gamma treatment compared to the...

Authors: Gade P, Roy SK, Li H, Nallar SC, Kalvakolanu DV

The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment

During vertebrate cell division, chromosomes oscillate with periods of smooth motion interrupted by abrupt reversals in direction. These oscillations must be spatially constrained in order to align and segregate chromosomes with high fidelity, but...

Authors: Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L

Restricted collision coupling of the A2A-receptor revisited: Evidence for physical separation of two signaling cascades

The A(2A)-adenosine receptor is a prototypical G(s) protein-coupled receptor, but stimulates MAP-kinase/erk in a Gs-independent way. The A(2A)-receptor has long been known to undergo restricted collision coupling with G(s); the mechanistic basis for...

Authors: Charalambous C, Gsandtner I, Keuerleber S, Milan-Lobo L, Kudlacek O, Freissmuth M, Zezula J

Expression of angiotensin converting enzyme changes MHC class I peptide presentation by modifying C-termini of peptide precursors

We recently reported a mouse model called ACE 10/10 in which macrophages over express the carboxypeptidase angiotensin converting enzyme (ACE). These mice have an enhanced inflammatory response to tumors that markedly inhibits tumor growth. Here, we...

Authors: Shen XZ, Lukacher AE, Williams IR, Bernstein KE

Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells

Migration of oligodendrocyte precursors along axons is a necessary prerequisite for myelination, but little is known about underlying mechanisms. NG2 is a large membrane proteoglycan implicated in oligodendrocyte migration. Here we show that a PDZ...

Authors: Chatterjee N, Stegmüller J, Schätzle P, Karram K, Koroll M, Werner HB, Nave KA, Trotter J

p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression

Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the...

Authors: Choi BH, Kim CG, Bae YS, Lim Y, Lee YH, Shin SY

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin