There is a citation from King's College London comparing Lonza's primary hepatocytes to stem-cell derived hepatocytes. Here is the link: https://sciencematters.io/articles/202004000002
Here are few key points from the article:
- CYP1A2 and CYP3A4 activity between iHeps (at Day 21) and primary hepatocytes were comparable.
- iPSC derived hepatocytes did not produce measurable amounts of albumin.
- iPSC derived hepatocytes did not metabolize ammonia to urea.
- iPSC derived hepatocytes maintained high levels of AFP through differentiation (Day 21), which indicate they have not fully matured. AFP is indicative of hepatoblast differentiation.