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Vif counteracts a cyclophilin A-imposed inhibition of Simian immunodeficiency viruses in human cells

Vif is a primate lentiviral accessory protein that is crucial for viral infectivity. Vif counteracts the antiviral activity of host deaminases such as APOBEC3G and APOBEC3F. We now report a novel function of African green monkey simian...

Authors: Takeuchi H, Buckler-White A, Goila-Gaur R, Miyagi E, Khan MA, Opi S, Kao S, Sokolskaja E, Pertel T,...

Dishevelled promotes axon differentiation by regulating atypical protein kinase C

The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown. Here, we report that in cultured hippocampal...

Authors: Zhang X, Zhu J, Yang GY, Wang QJ, Qian L, Chen YM, Chen F, Tao Y, Hu HS, Wang T, Luo ZG

Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth

Recent evidence has implicated dynein and its regulatory factors dynactin and LIS1 in neuronal and non-neuronal cell migration. In the current study we sought to test whether effects on neuronal cell motility might reflect, in part, a role for these...

Authors: Grabham PW, Seale GE, Bennecib M, Goldberg DJ, Vallee RB

SST Peer Reviewed

ATF2 impairs glucocorticoid receptor-mediated transactivation in human CD8+ T cells

Chronic inflammatory diseases often have residual CD8(+) T cell infiltration despite treatment with systemic corticosteroids suggesting divergent steroid responses between CD4(+) vs. CD8(+) cells. To examine steroid sensitivity, dexamethasone...

Authors: Li LB, Leung DY, Strand MJ, Goleva E

Thiazolidinediones Modulate the Expression of -Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box Proteins of SCF E3 Ubiquitin Ligase Independently of PPAR

Thiazolidinediones Modulate the Expression of beta-Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box ProtConsidering the role of aberrant beta-catenin signaling in tumorigenesis, we investigated the mechanism by which the...

Authors: Wei S, Lin LF, Yang CC, Wang YC, Chang GD, Chen H, Chen CS

Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-I expression

The Bax inhibitor-1 (BI-1) is an anti-apoptotic protein that is located in ER membranes and protects cells from ER stress-induced apoptosis. The ER is associated with generation of reactive oxygen species (ROS) through oxidative protein folding. This...

Authors: Lee GH, Kim HK, Chae SW, Kim DS, Ha KC, Mike C, Kress C, Reed JC, Kim HR, Chae HJ

A lethal defect of mitochondrial and peroxisomal fission

We report on a newborn girl with microcephaly, abnormal brain development, optic atrophy and hypoplasia, persistent lactic acidemia, and a mildly elevated plasma concentration of very-long-chain fatty acids. We found a defect of the fission of both...

Authors: Waterham HR, Koster J, van Roermund CW, Mooyer PA, Wanders RJ, Leonard JV

Expression of The P16ink4a Gene Is Associated Closely with Senescence of Human Mesenchymal Stem Cells, and Potentially Silenced by DNA Methylation During In Vitro Expansion

The precise biological characteristics of human mesenchymal stem cells (hMSCs), including growth regulatory mechanisms, have not yet been defined. Using 29 strains of hMSCs isolated from bone marrow, we have performed extensive analyses of the growth...

Authors: Shibata K, Aoyama T, Shima Y, Fukiage K, Otsuka S, Furu M, Kohno Y, Ito K, Fujibayashi S, Neo M,...

Delta-like 4 induces notch signaling in macrophages: implications for inflammation

BACKGROUND: Activated macrophages contribute to the pathogenesis of inflammatory diseases such as atherosclerosis. Although Notch signaling participates in various aspects of immunity, its role in macrophage activation remains undetermined. METHODS...

Authors: Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC,...

5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression

5-Androstenediol (5-AED) stimulates hematopoiesis and enhances survival in animals exposed to ionizing radiation (IR), suggesting that this steroid may act on hematopoietic progenitor cells. We used gamma-irradiated primary human CD34(+)...

Authors: Xiao M, Inal CE, Parekh VI, Chang CM, Whitnall MH

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