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HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells

Human T cell leukemia virus type I (HTLV-I) causes adult T cell leukemia (ATL) in 2-5% of carriers after a long latent period. An HTLV-I encoded protein, Tax, induces proliferation and inhibits apoptosis, resulting in clonal proliferation of infected...

Authors: Satou Y, Yasunaga J, Yoshida M, Matsuoka M

Functional analysis of SIRP in the growth cone

The signal regulatory protein' SIRPalpha is an Ig superfamily, transmembrane glycoprotein with a pair of cytoplasmic domains that can bind the phosphatase SHP-2 when phosphorylated on tyrosine. SIRPalpha is prominent in growth cones of rat cortical...

Authors: Wang XX and Pfenninger KH

Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian xenopus laevis and its involvement in hyaluronan synthesis

UDP-glucose dehydrogenase (UGDH) supplies the cell with UDP-glucuronic acid, a precursor of glycosaminoglycan and proteoglycan synthesis. In this study, we report the cloning and the characterization of the UGDH from the amphibian Xenopus laevis that...

Authors: Vigetti D, Ori M, Viola M, Genasetti A, Karousou E, Rizzi M, Pallotti F, Nardi I, Hascall VC, De...

Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS

A member of the IFN regulatory factor (IRF) family of transcription factors, IRF-4 is expressed in lymphocytes and macrophage/dendritic cells. Studies using IRF-4-deficient mice have revealed the critical roles of IRF-4 in lymphocyte responses....

Authors: Honma K, Udono H, Kohno T, Yamamoto K, Ogawa A, Takemori T, Kumatori A, Suzuki S, Matsuyama T and...

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

The pathogenesis of mucosa-associated lymphoid tissue (MALT) lymphomas is associated with independent chromosomal translocations that lead to the upregulation of either BCL10 or MALT1 or the generation of a fusion protein, cIAP2-MALT1. While both...

Authors: Hu S, Du MQ, Park SM, Alcivar A, Qu L, Gupta S, Tang J, Baens M, Ye H, Lee TH, Marynen P, Riley JL...

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Perifosine is a synthetic novel alkylphospholipid, a new class of anti-tumor agents which targets cell membranes and inhibits Akt activation. Here we show that baseline phosphorylation of Akt in MM cells is completely inhibited by Perifosine in a...

Authors: Hideshima T, Catley L, Yasui H, Ishitsuka K, Raje N, Mitsiades C, Podar K, Munshi NC, Chauhan D,...

Negative regulation of Toll-like-receptor signaling by IRF-4

The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and adaptive immune systems. TLR activation triggers the induction of downstream target genes, wherein the TLR-interacting adaptor...

Authors: Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T and Honda K

P-selectin binds to the D'-D3 domains of von Willebrand factor in Weibel-Palade bodies

It has recently been shown that the ultralarge platelet-recruiting VWF strings formed immediately at exocytosis from endothelial cells may be anchored to the cell surface by an interaction with the integral membrane protein P-selectin. This finding...

Authors: Michaux G, Pullen TJ, Haberichter SL and Cutler DF

Protease-Activated Receptor-2 Is Essential for Factor VIIa and Xa-Induced Signaling, Migration, and Invasion of Breast Cancer Cells

Protease-activated receptors (PAR) are G protein-coupled receptors that function as cell-surface sensors for coagulant proteases, as well as other proteases associated with the tumor microenvironment. PAR1 is activated by thrombin whereas the...

Authors: Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL and Trejo J

Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta

Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these...

Authors: Smalley MJ, Signoret N, Robertson D, Tilley A, Hann A, Ewan K, Ding Y, Paterson H and Dale TC

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