Search Results

ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.

PURPOSE: Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its...

Authors: Nugent LF1, Shi G, Vistica BP, Ogbeifun O, Hinshaw SJ, Gery I.

Staphylococcus epidermidis and Staphylococcus aureus trigger different interleukin-8 and intercellular adhesion molecule-1 in lung cells: implications for inflammatory complications following neonatal sepsis

AIM: Staphylococci are a major contribution for neonatal sepsis, which is the main risk factor for bronchopulmonary dysplasia. This study investigated the expression of pro-inflammatory mediators in endothelial and respiratory cells from newborns...

Authors: Ivarsson M, Schollin J, Björkqvist M

Growth and structural discrimination of cortical neurons on randomly oriented and vertically aligned dense carbon nanotube networks.

The growth of cortical neurons on three dimensional structures of spatially defined (structured) randomly oriented, as well as on vertically aligned, carbon nanotubes (CNT) is studied. Cortical neurons are attracted towards both types of CNT...

Authors: Nick C, Yadav S, Joshi R, Thielemann C, Schneider JJ.

SST Peer Reviewed

Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models

Increases in ceramide levels have been implicated in the pathogenesis of both acute or chronic lung injury models. However, the role of individual ceramide species, or of the enzymes that are responsible for their synthesis, in lung health and...

Authors: Petrache I, Kamocki K, Poirier C, Pewzner-Jung Y, Laviad EL, Schweitzer KS, Van Demark M, Justice...

Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro.

Antisense-mediated modulation of pre-mRNA splicing is an attractive therapeutic strategy for genetic diseases. Currently, there are few examples of modulation of pre-mRNA splicing using locked nucleic acid (LNA) antisense oligonucleotides, and, in...

Authors: Shimo T1, Tachibana K1, Saito K1, Yoshida T2, Tomita E3, Waki R1, Yamamoto T1, Doi T1, Inoue T2,...

Characterization of primary human skeletal muscle cells from multiple commercial sources.

There is a significant unmet need for safe, anabolic muscle therapies to treat diseases and conditions associated with severe muscle weakness and frailty. The identification of such therapies requires appropriate cell-based screening assays to select...

Authors: Owens J1, Moreira K, Bain G.

FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells.

FXYD5 (dysadherin or RIC) is a member of the FXYD family of single-span transmembrane proteins associated with the Na(+)-K(+)-ATPase. Several studies have demonstrated enhanced expression of FXYD5 during metastasis and effects on cell adhesion and...

Authors: Lubarski I1, Asher C, Garty H.

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock.

Tendons are prominent members of the family of fibrous connective tissues (FCTs), which collectively are the most abundant tissues in vertebrates and have crucial roles in transmitting mechanical force and linking organs. Tendon diseases are among...

Authors: Yeung CY1, Gossan N1, Lu Y1, Hughes A2, Hensman JJ3, Bayer ML4, Kjær M4, Kadler KE1, Meng QJ1

Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy.

AIMS: Nuclear factor erythroid-2-related factor 2 (Nrf2) appears to be a negative regulator of maladaptive cardiac remodelling and dysfunction; however, a potential of the Nrf2-mediated cardiac protection in diverse pathological settings remains...

Authors: Li J1, Zhang C, Xing Y, Janicki JS, Yamamoto M, Wang XL, Tang DQ, Cui T.

Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.

Endothelin-1 (ET-1) and activation of protein kinase C (PKC) have been implicated in alterations of myocyte function in cardiac hypertrophy and heart failure. Changes in cellular Ca2+ handling and electrophysiological properties also occur in these...

Authors: Puglisi JL1, Yuan W, Timofeyev V, Myers RE, Chiamvimonvat N, Samarel AM, Bers DM.

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