Search Results

Identification of RAI3 as a therapeutic target for breast cancer

We have been investigating gene-expression profiles in estrogen receptor (ER)-negative breast cancers to identify molecules involved in breast carcinogenesis and to select genes or gene products that might be useful as diagnostic markers or targets...

Authors: Nagahata T, Sato T, Tomura A, Onda M, Nishikawa K and Emi M

Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments

Recent studies have shown that the transport of microtubules (MTs) and neurofilaments (NFs) within the axon is rapid, infrequent, asynchronous, and bidirectional. Here, we used RNA interference to investigate the role of cytoplasmic dynein in...

Authors: He Y, Francis F, Myers KA, Yu W, Black MM and Baas PW

DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

Biochemical and genetic studies support the view that the majority of DNA double-strand breaks induced in the genome of higher eukaryotes by ionizing radiation are removed by two pathways of nonhomologous end joining (NHEJ) termed D-NHEJ and B-NHEJ....

Authors: Wang H, Rosidi B, Perrault R, Wang M, Zhang L, Windhofer F and Iliakis G

From Sorting Endosomes to Exocytosis: Association of Rab4 and Rab11 GTPases with the Fc Receptor, FcRn, during Recycling

A longstanding question in cell biology is how is the routing of intracellular organelles within cells regulated? Although data support the involvement of Rab4 and Rab11 GTPases in the recycling pathway, the function of Rab11 in particular is...

Authors: Ward ES, Martinez C, Vaccaro C, Zhou J, Tang Q and Ober RJ

The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration

Cell migration requires extension of lamellipodia that are stabilized by formation of adhesive complexes at the leading edge. Both processes are regulated by signaling proteins recruited to nascent adhesive sites that lead to activation of Rho...

Authors: Pratt SJ, Epple H, Ward M, Feng Y, Braga VM and Longmore GD

Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal

Although traditionally recognized for maintaining extracellular matrix integrity during morphogenesis, the function of matrix metallo-proteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), in the mature nervous...

Authors: Perez-Martinez L and Jaworski DM

The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells

Melphalan, a DNA cross-linker, is one of the most widely used and effective drugs in the treatment of multiple myeloma (MM). In this report, we demonstrate that enhanced interstrand cross-link (ICL) repair via the Fanconi anemia (FA)/BRCA pathway...

Authors: Chen Q, Van der Sluis PC, Boulware D, Hazlehurst LA and Dalton WS

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Myeloproliferative disorders are clonal haematopoietic stem cell malignancies characterized by independency or hypersensitivity of haematopoietic progenitors to numerous cytokines. The molecular basis of most myeloproliferative disorders is unknown....

Authors: James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, Garcon L, Raslova H, Berger R,...

Omenn syndrome due to ARTEMIS mutations

Omenn syndrome (OS) is characterized by severe combined immunodeficiency (SCID) associated with erythrodermia, hepatosplenomegaly, lymphadenopathy and alopecia. In OS patients, B-cells are mostly absent, T-cell counts are normal to elevated, and...

Authors: Ege M, Ma Y, Manfras B, Kalwak K, Lu H, Lieber MR, Schwarz K and Pannicke U

Adaptation of sensory neurons to hyalectin and decorin proteoglycans

Proteoglycans are abundantly expressed in the pathways of developing and regenerating neurons, yet the responses of neurons to specific proteoglycans are not well characterized. We have shown previously that one chondroitin sulfate proteoglycan...

Authors: Lemons ML, Barua S, Abanto ML, Halfter W and Condic ML

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