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Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.

Human ß defensin DEFB103 acts as both a stimulant and an attenuator of chemokine and cytokine responses: a dichotomy that is not entirely understood. Our predicted results using an in silico simulation model of dendritic cells and our observed...

Authors: Harvey LE, Kohlgraf KG, Mehalick LA, Raina M, Recker EN, Radhakrishnan S, Prasad SA, Vidva R,...

SST Peer Reviewed

Possible Mechanism of Low Endotoxin Recovery

Authors: M.Tsuchiya

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area.

BACKGROUND: Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (steel mills and associated...

Authors: Thomson EM1, Breznan D2, Karthikeyan S3, MacKinnon-Roy C4, Charland JP5, Dabek-Zlotorzynska E6, Celo...

Endotoxin recovery using limulus amebocyte lysate (LAL) assay.

A phenomenon initially reported by Chen and Vinther in 2013 [1], and now commonly referred to as low endotoxin recovery (LER), has prompted the Food and Drug Administration (FDA) to request specific data demonstrating the capability of the LAL BET...

Authors: Bolden JS, Warburton RE, Phelan R, Murphy M, Smith KR, De Felippis MR, Chen D.

SST Peer Reviewed

Masking of endotoxin in surfactant samples: Effects on Limulus-based detection systems.

Over the last few decades Limulus Amebocyte Lysate (LAL) has been the most sensitive method for the detection of endotoxins (Lipopolysaccharides) and is well accepted in a broad field of applications. Recently, Low Endotoxin Recovery (LER) in...

Authors: Reich J1, Lang P2, Grallert H3, Motschmann H4

SST Peer Reviewed

Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform

Autologous cell-based therapeutics have gained increasing attention in recent years because of their efficacy at treating diseases with limited therapeutic options. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical success in...

Authors: Trainor N, Purpura KA, Middleton K, Fargo K, Hails L, Vicentini-Hogan M, McRobie C, Daniels R,...

SST Peer Reviewed

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Category

Research Area

Topic

Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.

Possible Mechanism of Low Endotoxin Recovery

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area.

Endotoxin recovery using limulus amebocyte lysate (LAL) assay.

Masking of endotoxin in surfactant samples: Effects on Limulus-based detection systems.

Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform