Small Airway Epithelial Cell Growth Medium

Airway cell media are serum-free media that have been optimized for the proliferation of airway cells.
The SAGM BulletKit™ was specifically developed to provide superior growth for Human Small Airway Epithelial Cells

Shelf Life:
6 months
Recommended for Cells:
Epithelial, Small Airway, human (SAEC) ; Epithelial, Small Airway, human COPD
Categories:
Primary Cells and Media
Research Areas:
Cancer Research/Cell Biology
Basic Research
Respiratory Research
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Citations (54)

Highly scalable arrayed CRISPR mediated gene silencing in primary lungsmall airway epithelial cells
Categories:
Primary Cells and Media, Transfection 
Authors:
Dickson A, Mullooly N, Serrano A, Escudero-Ibarz L, Wiggins C, Gianni D 
In:
SLAS Discov (2023) 2: 29-35 
Hypoxia induces expression of angiotensin-converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID-19
Categories:
Primary Cells and Media 
Authors:
Anne Sturrock, Elizabeth Zimmerman, My Helms, Theodore G Liou, Robert Paine 3rd 
In:
Physiol Rep (2021) 9: e14854 
Migration of breast cancer cell lines in response to pulmonary laminin 332.
Categories:
Primary Cells and Media 
Authors:
Carpenter PM, Sivadas P, Hua SS, Xiao C, Gutierrez AB, Ngo T, Gershon PD 
In:
Cancer Medicine (2017) 6(1): 220-234 
CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes With Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner 
Categories:
Primary Cells and Media, 3D Cell Culture  
Authors:
Kwang-Il Jeong  1 , Peter A Piepenhagen  2 , Michael Kishko  1 , Joshua M DiNapoli  1 , Rachel P Groppo  1 , Linong Zhang  1 , Jeffrey Almond  1 , Harry Kleanthous  1 , Simon Delagrave  1 , Mark Parrington  1              
In:
PLoS ONE (2015) 10: 6 
Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pH.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Daidoji T, Watanabe Y, Ibrahim MS, Yasugi M, Maruyama H, Masuda T, Arai F, Ohba T, Honda A, Ikuta K, Nakaya T. 
In:
J Biol Chem (2015) unknown: unknown 
Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Furukawa M, Wheeler S, Clark AM, Wells A 
In:
PLoS ONE (2015) 10 (1): e0118060 
Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants
Categories:
 
Authors:
Chakraborty M, McGreal EP, Williams A, Davies PL, Powell W, Abdulla S, Voitenok NN, Hogwood J, Gray E, Spiller B, Chambers RC, Kotecha S 
In:
PLoS ONE (2014) 9(12): e114524 
A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Taguchi A1, Taylor AD2, Rodriguez J3, Celiktas M4, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S , Minna JD, Wistuba II, Gazdar AF, Hanash SM. 
In:
Cancer Res (2014) 74(17): 4694-705 
Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Khabibullin D, Medvetz DA, Pinilla M, Hariharan V, Li C, Hergrueter A, Laucho Contreras M, Zhang E, Parkhitko A, Yu JJ, Owen CA, Huang H, Baron RM, Henske EP 
In:
Respir Res (2014) 2(8): e12107 
Monocyte interaction accelerates HCl-induced lung epithelial remodeling.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Chen Q, Luo AA, Qiu H, Han B, Ko BH, Slutsky AS, Zhang H 
In:
BMC Pulm Med (2014) 14(135): 1471-79 
Dectin-1 is expressed in human lung and mediates the proinflammatory immune response to nontypeable Haemophilus influenzae
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Heyl KA, Klassert TE, Heinrich A, Müller MM, Klaile E, Dienemann H, Grünewald C, Bals R, Singer BB, Slevogt H 
In:
mBio (2014) 5(5): e01492-14 
Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Mendez JJ, Ghaedi M, Steinbacher D, Niklason LE. 
In:
Tissue Eng (2014) 20(11-12): 1735-46 
Isolation and Characterization of Alveolar Epithelial Type II Cells Derived from Mouse Embryonic Stem Cells
Categories:
 
Authors:
Sun H, Quan Y, Yan Q, Peng X, Mao Z, Wetsel RA, Wang D. 
In:
Tissue Eng (2014) 20(6): 464-72 
Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Siegrist KJ, Reynolds SH, Kashon ML, Lowry DT, Dong C, Hubbs AF, Young SH, Salisbury JL, Porter DW, Benkovic SA, McCawley M, Keane MJ, Mastovich JT, Bunker KL, Cena LG, Sparrow MC, Sturgeon JL, Dinu CZ1, Sargent LM 
In:
Particle and Fibre Toxicology (2014) 11(6): 1-15 
Down-regulation of Filamin A interacting protein 1-like Is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Kwon M, Lee SJ, Reddy S, Rybak Y, Adem A, Libutti SK 
In:
PLoS ONE (2013) 8(12): e82620 
System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Snyder-Talkington BN1, Dymacek J, Porter DW, Wolfarth MG, Mercer RR, Pacurari M, Denvir J, Castranova V, Qian Y, Guo NL 
In:
Toxicol Appl Pharmacol (2013) 272(2): 476-89 
Systems approaches to modeling chronic mucosal inflammation.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Kalita M, Tian B, Gao B, Choudhary S, Wood TG, Carmical JR, Boldogh I, Mitra S, Minna JD, Brasier AR. 
In:
Biomed Res Int. (2013) 2013: 17 
Regulation of CYP3A genes by glucocorticoids in human lung cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Roberts JK1, Moore CD1, Romero EG1, Ward RM2, Yost GS1, Reilly CA1. 
In:
Other (2013) 2: 173 
Vitamin D induces interleukin-1ß expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection
Categories:
 
Authors:
Verway M, Bouttier M, Wang TT, Carrier M, Calderon M, An BS, Devemy E, McIntosh F, Divangahi M, Behr MA, White JH. 
In:
PLoS Pathog (2013) 9(6): e1003407 
Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Liu AR, Liu L, Chen S, Yang Y, Zhao HJ, Liu L, Guo FM, Lu XM, Qiu HB. 
In:
J Cell Physiol (2013) 228(6): 1270-83 
Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Petrache I, Kamocki K, Poirier C, Pewzner-Jung Y, Laviad EL, Schweitzer KS, Van Demark M, Justice MJ, Hubbard WC, Futerman AH 
In:
PLoS ONE (2013) 8(5): e62968 
PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H 
In:
Scientific Reports (2013) 3: 1911 
Sevoflurane suppresses tumour necrosis factor-a-induced inflammatory responses in small airway epithelial cells after anoxia/reoxygenation.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Watanabe K, Iwahara C, Nakayama H, Iwabuchi K, Matsukawa T, Yokoyama K, Yamaguchi K, Kamiyama Y, Inada E 
In:
British Journal of Anaesthsia (2013) 110(4):: 637-45 
Down-Regulation of Canonical and Up-Regulation of Non-Canonical Wnt Signalling in the Carcinogenic Process of Squamous Cell Lung Carcinoma
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Bartis D, Csongei V, Weich A, Kiss E, Barko S, Kovacs T, Avdicevic M, D\\\\\\\'Souza VK, Rapp J, Kvell K, Jakab L, Nyitrai M, Molnar TF, Thickett DR, Laszlo T, Pongracz JE 
In:
PLoS ONE (2013) 8(3): e57393 
Role of ß-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Zemans RL1, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP 
In:
Am J Physiol Lung Cell Mol Physiol (2013) 304(6): 415-27 
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3ß pathway in mice
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Yadav UC, Naura AS, Aguilera-Aguirre L, Boldogh I, Boulares HA, Calhoun WJ, Ramana KV, Srivastava SK 
In:
PLoS ONE (2013) 8(2): e57442 
Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma
Categories:
Primary Cells and Media 
Authors:
Bartis D, Csongei V, Weich A, Kiss E, Barko S, Kovacs T, Avdicevic M, D'Souza VK, Rapp J, Kvell K, Jakab L, Nyitrai M, Molnar TF, Thickett DR, Laszlo T, Pongracz JE. 
In:
PLoS ONE (2013) 8(3): e57393 
Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Akram KM, Samad S, Spiteri MA, Forsyth NR. 
In:
Respir Res (2013) 14: 9 
A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJ. 
In:
PLoS ONE (2013) 8(3): e58258 
Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Akram KM, Samad S, Spiteri MA, Forsyth NR 
In:
Respir Res (2013) 14: 9 
Production and Assessment of Decellularized Pig and Human Lung Scaffolds
Categories:
 
Authors:
Joan E. Nichols, PhD, Jean Niles, MA, Michael Riddle, MD, Gracie Vargas, PhD, Tuya Schilagard, PhD, Liang Ma, PhD, Kert Edward, PhD, Saverio La Francesca, Jason Sakamoto, PhD, Stephanie Vega, BS, Marie Ogadegbe, BS, Ronald Mlcak, PhD, Donald Deyo, DVM, Lee Woodson, MD, Christopher McQuitty, MD, Scott Lick, MD, Daniel Beckles, MD, Esther Melo, MA, and Joaquin Cortiella MD, MPH 
In:
Tissue Eng (2013) 19: 2045-2062 
Staphylococcus epidermidis and Staphylococcus aureus trigger different interleukin-8 and intercellular adhesion molecule-1 in lung cells: implications for inflammatory complications following neonatal sepsis
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Ivarsson M, Schollin J, Björkqvist M 
In:
Acta Paediatr. (2012) 102(10): 1010-6 
Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer
Categories:
Primary Cells and Media, Bioassay  
Authors:
Valles I, Pajares MJ, Segura V, Guruceaga E, Gomez-Roman J, Blanco D, Tamura A, Montuenga LM, Pio R. 
In:
PLoS ONE (2012) Identificati: 7(8) 
NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Luzina IG, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE. 
In:
J Biol Chem (2012) 287(11): 8214-31 
Local small airway epithelial injury induces global smooth muscle contraction and airway constriction
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC 
In:
Journal of Applied Physiology (2012) 112(4): 627-37 
Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.
Categories:
Primary Cells and Media 
Authors:
Thomas KC, Roberts JK, Deering-Rice CE, Romero EG, Dull RO, Lee J, Yost GS, Reilly CA. 
In:
Am J Physiol Lung Cell Mol Physiol (2012) 302(1):: L111-9 
Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Sundar IK, Chung S, Hwang JW, Lapek JD Jr, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I 
In:
PLoS ONE (2012) 7: 2 
Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-a after injury.
Categories:
 
Authors:
Maillé E, Trinh NT, Privé A, Bilodeau C, Bissonnette E, Grandvaux N, Brochiero E. 
In:
Am J Physiol Lung Cell Mol Physiol (2011) 301(6): L945-55 
Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Rao M1, Chinnasamy N, Hong JA, Zhang Y, Zhang M, Xi S, Liu F, Marquez VE, Morgan RA, Schrump DS. 
In:
Cancer Res (2011) 71(12): 4192-204 
Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Filby CE, Williamson R, van Kooy P, Pébay A, Dottori M, Elwood NJ, Zaibak F. 
In:
Stem Cell Res Ther (2011) 2(2): 1186-99 
Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.
Categories:
Primary Cells and Media 
Authors:
Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S 
In:
PLoS ONE (2011) 6(12): e28714 
Aldose reductase inhibition prevents metaplasia of airway epithelial cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Yadav UC, Aguilera-Aguirre L, Ramana KV, Boldogh I, Srivastava SK 
In:
PLoS ONE (2010) 5(12): e14440 
IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, Saito H, Matsuda A. 
In:
J Immunol (2010) 185(10): 5743-50 
The oncoprotein SF2/ASF promotes non-small cell lung cancer survival by enhancing survivin expression.
Categories:
Primary Cells and Media 
Authors:
Ezponda T, Pajares MJ, Agorreta J, Echeveste JI, López-Picazo JM, Torre W, Pio R, Montuenga LM. 
In:
Clin Cancer Res (2010) 16(16): 4113-25 
Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media, Transfection 
Authors:
Harada Y, Kanehira M, Fujisawa Y, Takata R, Shuin T, Miki T, Fujioka T, Nakamura Y, Katagiri T. 
In:
Cancer Res (2010) 70(14): 5829-39 
Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Liu W, Tundwal K, Liang Q, Goplen N, Rozario S, Quayum N, Gorska M, Wenzel S, Balzar S, Alam R 
In:
Nat Cell Biol (2010) 30(7): 1783-99 
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Yadav UC, Naura AS, Aguilera-Aguirre L, Ramana KV, Boldogh I, Sur S, Boulares HA, Srivastava SK 
In:
J Immunol (2009) 183(7): 4723-32 
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Yadav UC, Ramana KV, Aguilera-Aguirre L, Boldogh I, Boulares HA, Srivastava SK 
In:
PLoS ONE (2009) 4(8): e6535 
IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Kolliputi N, Waxman AB. 
In:
Am J Physiol Lung Cell Mol Physiol (2009) 297(1): L6-16 
alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Moretto N1, Facchinetti F, Southworth T, Civelli M, Singh D, Patacchini R. 
In:
Am J Physiol Lung Cell Mol Physiol (2009) 296(5): L839-48 
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Categories:
Primary Cells and Media 
Authors:
Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG 
In:
J Cell Sci (2009) 122(Pt 8): 1238-47 
Lung epithelial injury by B. anthracis lethal toxin is caused by MKK-dependent loss of cytoskeletal integrity
Categories:
Primary Cells and Media 
Authors:
Lehmann M, Noack D, Wood M, Perego M, Knaus UG. 
In:
PLoS ONE (2009) 4(3): e4755 
Initial observations on the effect of medium composition on the differentiation of murine embryonic stem cells to alveolar type II cells.
Categories:
Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Rippon HJ, Ali NN, Polak JM, Bishop AE. 
In:
Cloning and Stem Cells (2004) 6(2): 49-56 
A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells.
Categories:
Primary Cells and Media 
Authors:
Li AP1, Bode C, Sakai Y 
In:
Chem Biol (2004) 150(1): 129-36 
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