Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells
Authors:
Carter BZ, Mak DH, Schober WD, McQueen T, Harris D, Estrov Z, Evans RL, Andreeff M
In:
Source:
Blood
Publication Date:
(
2006
)
Issue:
108(2)
:
630-7
Research Area:
Cancer Research/Cell Biology
Immunotherapy / Hematology
Cells used in publication:
OCI-AML3
Species: human
Tissue Origin: blood
Platform:
Nucleofector® I/II/2b
Abstract
Triptolide, a diterpenoid isolated from the Chinese herb Tripterygium wilfordii Hook.f, has shown anti-tumor activities in a broad range of solid tumors. Here we examined its effects on leukemic cells and found that, at 100
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