Loss of fibulin-2 expression is associated with breast cancer progression

Authors:
Yi CH, Smith DJ, West WW, Hollingsworth MA
In:
Source: Am J Pathol
Publication Date: (2007)
Issue: 170(5): 1535-45
Research Area:
Cancer Research/Cell Biology
Cells used in publication:
BT-20
Species: human
Tissue Origin: breast
MDA-MB-231
Species: human
Tissue Origin: breast
Platform:
Nucleofectorâ„¢ I/II/2b
Abstract
Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.