Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency

Kondo K, Nozaki H, Shimada K and Yamanishi K
Source: J Virol
Publication Date: (2003)
Issue: 77(19): 10719-10724
Cells used in publication:
PBMC, human
Species: human
Tissue Origin: blood
The U3-U7 gene cluster of human herpesvirus 6 (HHV-6) was replaced with an enhanced green fluorescent protein-puromycin gene cassette containing the cytomegalovirus major immediate-early promoter. Neither viral replication in T cells nor latency and reactivation in macrophages was impaired. During HHV-6 latency, the cytomegalovirus promoter used the transcription start sites employed in cytomegalovirus latency.