Osteoclast precursor (OCP), human

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Osteoclasts are large multinucleated cells formed from differentiated monocytes/macrophages, responsible for the breakdown of bone

Cell Type:
Bone
Tissue Origin:
bone marrow
Species:
human
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Research Area:
Cancer Research/Cell Biology
Dermatology/Tissue Engineering
Cell Characteristics:
Adherent

Transfection Information

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Citations (26)

Modulation of Alendronate release from a calcium phosphate bone cement: An in vitro osteoblast-osteoclast co-culture study
Categories:
Primary Cells and Media 
Authors:
Dolci LS, Panzavolta S, Torricelli P, Albertini B, Sicuro L, Fini M, Bigi A, Passerini N 
In:
Int J Pharm (2019) 554: 245-255 
Strontium-Substituted Hydroxyapatite-Gelatin Biomimetic Scaffolds Modulate Bone Cell Response.
Categories:
Primary Cells and Media 
Authors:
Panzavolta S1, Torricelli P2, Casolari S1, Parrilli A2, Fini M2, Bigi A1 
In:
Other (2018) 18(7): e1800096 
The HIV co-receptor CCR5 regulates osteoclast function.
Categories:
Primary Cells and Media 
Authors:
Lee JW, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, Ueha S, Matsushima K, Yamaguchi A, Imai Y, Iimura T. 
In:
Nat Commun. (2017) 8(1): 2226 
Quercetin and alendronate multi-functionalized materials as tools to hinder oxidative stress damage.
Categories:
Primary Cells and Media 
Authors:
Forte L, Torricelli P, Boanini E, Rubini K, Fini M, Bigi A 
In:
J Biomed Mater Res A (2017) 105: 3293-3303 
Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care
Categories:
Primary Cells and Media 
Authors:
Gillooly KM, Pulicicchio C, Pattoli MA, Cheng L, Skala S, Heimrich EM, McIntyre KW, Taylor TL, Kukral DW, Dudhgaonkar S, Nagar J, Banas D, Watterson SH, Tino JA, Fura A, Burke JR. 
In:
PLoS ONE (2017) 12: e0181782 
An advanced tri-culture model to evaluate the dynamic interplay among osteoblasts, osteoclasts, and endothelial cells.
Categories:
Primary Cells and Media 
Authors:
Pagani S1, Torricelli P1, Veronesi F1, Salamanna F2, Cepollaro S1,3, Fini M1 
In:
J Cell Physiol (2017) 233: 291-301 
Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Hoshino A, Hanada S, Yamada H, Mii S, Takahashi M, Mitarai S, Yamamoto K, Manome Y 
In:
Other (2014) 70(1): 28-39 
Potentiation of osteoclastogenesis by adipogenic conversion of bone marrow-derived mesenchymal stem cells.
Categories:
 
Authors:
Mori K, Suzuki K, Hozumi A, Goto H, Tomita M, Koseki H, Yamashita S, Osaki M 
In:
Biomed Res Int. (2014) 35(2): 153-9 
Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Kunii R, Yamaguchi M, Tanimoto Y, Asano M, Yamada K, Goseki T, Kasai K. 
In:
Other (2013) 43(6): 294-301 
A unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Haegel H, Thioudellet C, Hallet R, Geist M, Menguy T, Le Pogam F, Marchand JB, Toh ML, Duong V, Calcei A, Settelen N, Preville X, Hennequi M, Grellier B, Ancian P, Rissanen J, Clayette P, Guillen C, Rooke R, Bonnefoy JY. 
In:
Other (2013) 5(5): 736-747 
Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
Categories:
Primary Cells and Media 
Authors:
He W, Mazumder A, Wilder T, Cronstein BN 
In:
FASEB J (2013) 27(9): 3446-54 
Comparative in vitro study of four commercial biomaterials used for bone grafting.
Categories:
Primary Cells and Media, Bioassay  
Authors:
Bosetti M, Bianchi AE, Zaffe D, Cannas M 
In:
Other (2013) 11(2): 80-8 
In vitro response of Human Pre-osteoclasts to low intensity Laser irradiation
Categories:
Primary Cells and Media 
Authors:
Domíngueza A, Bayonab G, Casasb A 
In:
Other (2012) 2(8): 733-741 
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production
Categories:
Primary Cells and Media, Bioassay  
Authors:
LaBranche TP, Jesson MI, Radi ZA, Storer CE, Guzova JA, Bonar SL, Thompson JM, Happa FA, Stewart ZS, Zhan Y, Bollinger CS, Bansal PN, Wellen JW, Wilkie DP, Bailey SA, Symanowicz PT, Hegen M, Head RD, Kishore N, Mbalaviele G, Meyer DM 
In:
Arthritis Rheum (2012) 64(11): 3531-42 
Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse.
Categories:
 
Authors:
Murrills RJ, Fukayama S, Boschelli F, Matteo JJ, Owens J, Golas JM, Patel D, Lane G, Liu YB, Carter L, Jussif J, Spaulding V, Wang YD, Boschelli DH, McKew JC, Li XJ, Lockhead S, Milligan C, Kharode YP, Diesl V, Bai Y, Follettie M, Bex FJ, Komm B, Bodine PV. 
In:
J Pharmacol Exp Ther (2012) 340(3): 676-87 
The Chemical and Physical Properties of Poly(e-caprolactone) Scaffolds Functionalised with Poly(vinyl phosphonic acid-co-acrylic acid).
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Bassi AK, Gough JE, Zakikhani M, Downes S. 
In:
Tissue Eng (2011) 2011(615328): ePub 
A potent and selective cFMS inhibitor regulates the tumor macrophage microenvironment leading to tumor growth inhibition
Categories:
Primary Cells and Media 
Authors:
Wright AD, Willis BS, Gomez A, Boys ML, DeLisle RK, Burgess LE, Munson MC, Kennedy AL, Topalov GT, Zhao Q, Rodriguez ME, Rast B, Rizzi JP, DeWolf WE, Lemieux C, Anderson D, Neale JR, Martinson M, Gross SD, Callejo M, Risom T, Lee PA 
In:
Cancer Res (2011) 71(8 Supp): 551 
A-type cranberry proanthocyanidins inhibit the RANKL-dependent differentiation and function of human osteoclasts.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media, Bioassay  
Authors:
Tanabe S, Santos J, La VD, Howell AB, Grenier D. 
In:
Molecules (2011) 16(3): 2365-2374 
Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Goto H, Osaki M, Fukushima T, Sakamoto K, Hozumi A, Baba H, Shindo H. 
In:
Biomed Res Int. (2011) 32(1): 37-44 
Mitf induction by RANKL is critical for osteoclastogenesis
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media 
Authors:
Lu SY, Li M, Lin YL. 
In:
Mol Biol Cell (2010) 21(10): 1763-71 
Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes
Categories:
Primary Cells and Media 
Authors:
Platt I, El-Sohemy A 
In:
Other (2009) 8(15): ePub 
Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPARgamma agonist pioglitazone.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media, Bioassay  
Authors:
Syversen U, Stunes AK, Gustafsson BI, Obrant KJ, Nordsletten L, Berge R, Thommesen L, Reseland JE 
In:
Other (2009) 9:10: 1-13 
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
Categories:
Primary Cells and Media 
Authors:
Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ. 
In:
Proc Natl Acad Sci USA (2008) 105(52): 20764-9 
Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway.
Categories:
Primary Cells and Media, Classical Media and Reagents, Serum-free and Speciality Media, Bioassay  
Authors:
Stein NC, Kreutzmann C, Zimmermann SP, Niebergall U, Hellmeyer L, Goettsch C, Schoppet M, Hofbauer LC 
In:
Other (2008) 23(5): 750-8 
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans
Categories:
Transfection 
Authors:
Van Wesenbeeck L, Odgren PR, Coxon FP, Frattini A, Moens P, Perdu B, Mackay CA, Van Hul E, Timmermans JP, Vanhoenacker F, Jacobs R, Peruzzi B, Teti A, Helfrich MH, Rogers MJ, Villa A, Van Hul W 
In:
J Clin Invest (2007) 117(4): 919-930 
A novel method for efficient generation of transfected human osteoclasts
Categories:
Transfection 
Authors:
Taylor A, Rogers MJ, Tosh D, Coxon FP 
In:
Calcif Tissue Int (2007) 80(2): 132-6 
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