cells

A mantle cell lymphoma (MCL) cell line established from peripheral blood mononuclear cells of a patient with a large cell variant of MCL showing leukaemic conversion. [Jeon et al. Br J Haematol. 1998 Sep;102(5):1323-6]

Cell Type:

B cell

Tissue Origin:

blood

Species:

human

Research Area:

Immunotherapy / Hematology

Cell Characteristics:

Suspension

Transfection Information

Lonza Optimized Protocol
Optimization Guideline

Filter:

The table below shows data for the cell type and Nucleofector™ Platform selected. Those data are either based on Lonza Optimized Protocols or on results shared from customers who performed an optimization based on our guidelines. In case no data are shown for the selected Nucleofector™ Platform, please take a look at our optimization strategy to get further guidance on how to easily determine optimal Nucleofection conditions yourself.

Protocol	Kit	Program	Cells	Efficiency	Viable Cells	Substrate		Format	Platform
	V	X-001	2e6	74%	48%	Plasmid (general)	2 µg	100 µl	I/II/2b

Citations

A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers

Categories:

Primary Cells and Media, Transfection

Authors:

Derek P Wong , Nand K Roy , Keman Zhang , Anusha Anukanth, Abhishek Asthana , Nicole J Shirkey-Son , Samantha Dunmire , Bryan J Jones , Walker S Lahr , Beau R Webber , Branden S Moriarity , Paolo Caimi , Reshmi Parameswaran

In:

Nat Commun. (2022) 13: 217

SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma.

Categories:

Transfection, Cell Lines and Primary Cancer Cells

Authors:

Kuci V, Nordström L, Conrotto P, Ek S.

In:

Leuk Lymphoma (2016) 57(8): 1883-92

Biological rational for sequential targeting of Bruton tyrosine kinase and Bcl-2 to overcome CD40-induced ABT-199 resistance in mantle cell lymphoma.

Categories:

Transfection, Cell Lines and Primary Cancer Cells

Authors:

Chiron D, Dousset C, Brosseau C, Touzeau C, Maïga S, Moreau P, Pellat-Deceunynck C, Le Gouill S, Amiot M.

In:

OncoTarget (2015) 6(11): 8750-9

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

Categories:

Transfection

Authors:

Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E and Colomer D

In:

Blood (2006) 107(1): 257-264

JeKo-1

Transfection Information

Citations