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4741 results sorted by

Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells

HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART). We describe here a novel post-transcriptional block in HIV-1 gene expression in resting CD4+ T cells...
Authors: Lassen KG, Ramyar KX, Bailey JR, Zhou Y, Siliciano RF

DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2

Disrupted-in-Schizophrenia-1 (DISC1) is a candidate gene for susceptibility of schizophrenia. In the accompanying paper (Taya et al., 2006), we report that DISC1 acts as a linker between Kinesin-1 and DISC1-interacting molecules, such as NudE-like,...
Authors: Shinoda T, Taya S, Tsuboi D, Hikita T, Matsuzawa R, Kuroda S, Iwamatsu A, Kaibuchi K

NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN

The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN...
Authors: Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P,...

An Essential Role for Talin during M2-mediated Phagocytosis

The cytoskeletal, actin-binding protein talin has been previously implicated in phagocytosis in Dictyostelium discoideum and mammalian phagocytes. However, its mechanism of action during internalization is not understood. Our data confirm that...
Authors: Lim J, Wiedemann A, Tzircotis G, Monkley SJ, Critchley DR, Caron E

c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation

Reactive oxygen species (ROS) have been closely associated with both apoptotic and non-apoptotic/necrotic cell death. Our previous study has illustrated that c-Jun-N-terminal kinase 1 (JNK1) is the main executor in hydrogen peroxide...
Authors: Zhang S, Lin Y, Kim YS, Hande MP, Liu ZG, Shen HM

PGJ2 stimulated beta-cell apoptosis is associated with prolonged UPR activation

Peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands have been shown to possess anti-inflammatory properties that include the inhibition of transcription factor activation and the expression of inflammatory genes. Using pancreatic...
Authors: Chambers KT, Weber SM, Corbett JA

Transgenic human fetal fibroblasts as feeder layer for human embryonic stem cell lineage selection

Successful gene targeting in human embryonic stem (hES) cells requires the use of primary fibroblast feeder layers, which assist in the maintenance of the pluripotent state of hES cells. Such feeder layers must also survive any further selection...
Authors: Sidhu KS, Lie KH, Tuch BE

Physiologically high concentrations of 17-beta-estradiol enhance NF-kappaB activity in human T cells

Estrogen has diverse effects on inflammation and immune responses. That pregnancy is associated with remission of some autoimmune diseases and exacerbation of others suggests that physiological fluctuation in estrogen levels could affect the immune...
Authors: Hirano S, Furutama D, Hanafusa T

Regulation of S6 kinase 1 activation by phosphorylation at Ser411

Ribosomal S6 kinase 1 (S6K1), as a key regulator of mRNA translation, plays an important role in cell cycle progression through the G(1) phase of proliferating cells and in the synaptic plasticity of terminally differentiated neurons. Activation of...
Authors: Hou Z, He L, Qi RZ

PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53

PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have...
Authors: You X, Boyle DL, Hammaker D, Firestein GS