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Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk

The multilineage differentiation potential of adult tissue-derived mesenchymal progenitor cells (MPCs), such as those from bone marrow and trabecular bone, makes them a useful model to investigate mechanisms regulating tissue development and...
Authors: Tuli R, Tuli S, Nandi S, Huang X, Manner PA, Hozack WJ, Danielson KG, Hall DJ and Tuan RS

Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-B and simian virus 40 promoter factor 1 pathways

The pathogenesis of systemic sclerosis (SSc) is characterized by activation of the immune system, impaired angiogenesis, and activated dermal fibroblasts. The effects of the immunosuppressive agent bucillamine (SA 96) on fibroblasts and angiogenic...
Authors: Distler JHW, Hagen C, Hirth A, Muller-Ladner U, Lorenz HM, del Rosso A, Michel BA, Gay RE, Nanagara...

Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification

Anergy is a state of immunologic tolerance in which T cells are viable but incapable of responding to antigenic stimulation. Recent data indicate that anergic cells have a distinct gene expression program that determines their unique function. In...
Authors: Tzachanis D, Appleman LJ, van Puijenbroek AAFL, Berezovskaya A, Nadler LM and Boussiotis VA

Toll-like receptor signaling alters the expression of regulator of g protein signaling proteins in dendritic cells: implications for g protein-coupled receptor signaling

Conserved structural motifs on pathogens trigger pattern recognition receptors present on APCs such as dendritic cells (DCs). An important class of such receptors is the Toll-like receptors (TLRs). TLR signaling triggers a cascade of events in DCs...
Authors: Shi GX, Harrison K, Han SB, Moratz C and Kehrl JH

Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase A inhibits T cell receptor signaling

Raft-associated Csk controls signaling through the T cell receptor (TCR) and was mainly anchored to Cbp/PAG (phosphoprotein associated with glycosphingolipid-enriched membrane domains). Treatment of cells with the cAMP-elevating agent prostaglandin...
Authors: Vang T, Abrahamsen H, Myklebust S, Horejesi V and Taskén K

A central role for the Jun-N-terminal kinase pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven Smad3/4 specific gene expression

We have focused our attention on the molecular events underlying the antagonistic activities of pro-inflammatory cytokines against transforming growth factor-beta (TGF-beta)/SMAD signaling. Using jnk1/2-knockout (jnk(-/-)) and I kappa B...
Authors: Verrecchia F, Tacheau C, Wagner EF and Mauviel A

Cutting Edge: TGF-beta Induces a Regulatory Phenotype in CD4(+)CD25(-) T Cells through Foxp3 Induction and Down-Regulation of Smad7

CD4(+)CD25(+) regulatory cells are a subpopulation of T lymphocytes of thymic origin. However, recent data suggest an alternative commitment of regulatory T cells in the periphery, although the precise mechanism is unknown. In the present work, we...
Authors: Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR and Neurath MF

Distinct involvement of the Jun-N-terminal kinase and NF-kappaB pathways in the expression of the human COL1A2 gene by TNF-alpha

We used a gene knockout approach to elucidate the specific roles played by the Jun-N-terminal kinase (JNK) and NF-kappaB pathways downstream of TNF-alpha in the context of alpha(2) type I collagen gene (COL1A2) expression. In JNK1-/--JNK2-/- (JNK-/-)...
Authors: Verrecchia F, Wagner EF and Mauviel A

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

The unrestrained growth of tumor cells is generally attributed to mutations in essential growth control genes, but tumor cells are also influenced by signals from the environment. In multiple myeloma (MM), the factors and signals coming from the bone...
Authors: Derksen PWB, Tjin E, Meijer HP, Klok MD, Mac Gillavry HD, van Oers MHJ, Lokhorst HM, Bloem AC,...

Coordinate notch 3-hairy related transscription factor pathway regulation in response to arterial injury: mediator role of PDGF and ERK

The Notch family of receptors and downstream effectors plays a critical role in cell fate determination during vascular ontogeny. Moreover, the human cerebral autosomal dominant artriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
Authors: Wang W, Campos AH, Prince CZ, Mou Y and Pollmann MJ
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