Search Results

Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is critical for mediating Toll-like receptor (TLR)-interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity....

Authors: Wang Y, Tang Y, Teng L, Wu Y, Zhao X and Pei G

Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death

Restimulation of the T-cell receptor (TCR) in activated T cells induces CD95 (Fas/Apo-1)-mediated activation-induced cell death (AICD). The TCR-proximal mechanisms leading to AICD are elusive. Here we characterize hematopoietic progenitor kinase 1...

Authors: Brenner D, Golks A, Kiefer F, Krammer PH and Arnold R

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP(3)R

Members of the Bcl-2 protein family modulate outer mitochondrial membrane permeability to control apoptosis. However, these proteins also localize to the endoplasmic reticulum (ER), the functional significance of which is controversial. Here we...

Authors: White C, Li C, Yang J, Petrenko NB, Madesh M, Thompson CB and Foskett JK

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

Scribble (Scrib) is a conserved polarity protein required in Drosophila melanogaster for synaptic function, neuroblast differentiation, and epithelial polarization. It is also a tumor suppressor. In rodents, Scrib has been implicated in receptor...

Authors: Qin Y, Capaldo C, Gumbiner BM and Macara IG

The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression

Glucocorticoids dramatically inhibit cytokine and chemokine production. They act through the glucocorticoid receptor (GR), a ligand-dependent transcription factor that binds to and represses activities of other DNA-bound regulators, activator protein...

Authors: Reily MM, Pantoja C, Hu X, Chinenov Y and Rogatsky I

Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

BCR/ABL-kinase mutations frequently mediate clinical resistance to the selective tyrosine kinase inhibitor Imatinib mesylate (IM, Gleevec((R))). However, mechanisms that promote survival of BCR/ABL-positive cells before clinically overt IM resistance...

Authors: Burchert A, Wang Y, Cai D, von Bubnoff N, Paschka P, Muller-Brusselbach S, Ottmann OG, Duyster J,...

Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in MDCK cells

The Ca2+-independent immunoglobulin-like molecule nectin first forms cell-cell adhesions and then assembles cadherin at nectin-based cell-cell adhesion sites, resulting in the formation of adherens junctions (AJs). Afadin is a nectin- and actin...

Authors: Sato T, Fujita N, Yamada A, Ooshio T, Okamoto R, Irie K and Takai Y

Cdk5 phosphorylates and stabilizes p27(kip1) contributing to actin organization and cortical neuronal migration

p27(kip1), a cyclin-dependent kinase (CDK) inhibitor (CKI), generally suppresses CDK activity in proliferating cells. Although another role of p27 in cell migration has been recently suggested in vitro, the physiological importance of p27 in cell...

Authors: Kawauchi T, Chihama K, Nabeshima Y and Hoshino M

BBC3 mediates fenretinide-induced cell death in neuroblastoma

Fenretinide (4-HPR) is a synthetic retinoid whose apoptosis-inducing effects have been demonstrated in many tumor types. The precise mechanism of its apoptotic action is not fully understood. To further study the mechanism by which 4-HPR exerts its...

Authors: Wei JS, Whiteford CC, Cenacchi N, Son CG and Khan J

Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells

Stimulation of resting CD4 T cells with anti-CD3/CD28-coated beads leads to rapid polarization of lipid rafts (LRs). It has been postulated that a major role of costimulation is to facilitate LR aggregation. CD86 is up-regulated or expressed...

Authors: Kovacs B, Parry RV, Ma Z, Fan E, Shivers DK, Freiberg BA, Thomas AK, Rutherford R, Rumbley CA, Riley...

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