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CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase- independent manner

The molecular mechanisms responsible for the sustained basal motility of T cells within lymph nodes (LNs) remain elusive. To study T cell motility in a LN environment, we have developed a new experimental system based on slices of LNs that allows the...

Authors: Asperti-Boursin F, Real E, Bismuth G, Trautmann A, Donnadieu E

A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal

A wide range of RNA viruses use programmed -1 ribosomal frameshifting for the production of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the SARS-CoV genome revealed that, similar to all coronaviruses, a...

Authors: Plant EP, Perez-Alvarado GC, Jacobs JL, Mukhopadhyay B, Hennig M, Dinman JD

Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line

The complete resection of pituitary adenomas (PAs) is unlikely when there is an extensive local dural invasion and given that the molecular mechanisms remain primarily unknown. DNA microarray analysis was performed to identify differentially...

Authors: Hussaini IM, Trotter C, Zhao Y, Abdel-Fattah R, Amos S, Xiao A, Agi CU, Redpath GT, Fang Z, Leung...

The Role of the NADPH Oxidase Complex, p38 MAPK and Akt in Regulating Human Monocyte/Macrophage Survival

The Role of the NADPH Oxidase Complex, p38 MAPK, and Akt in Regulating Human Monocyte/Macrophage Survival. Wang Y, Zeigler MM, Lam GK, Hunter MM-CSF induces PI 3-kinase activation, resulting in reactive oxygen species (ROS) production. Previously,...

Authors: Wang Y, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, Tridandapani SV, Sen CK, Marsh CB

Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells

CDCP1, a novel stem cell marker, is expressed in hematopoietic cell line K562 but not in Jurkat. When CDCP1 promoter was transfected exogenously, Jurkat showed comparable promoter activity with K562, suggesting that the factor to enhance...

Authors: Kimura H, Morii E, Ikeda JI, Ezoe S, Xu JX, Nakamichi N, Tomita Y, Shibayama H, Kanakura Y, Aozasa...

Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling

Infection by Borna disease virus (BDV) enables the study of the molecular mechanisms whereby a virus can persist in the central nervous system and lead to altered brain function in the absence of overt cytolysis and inflammation. This neurotropic...

Authors: Volmer R, Monnet C, Gonzalez-Dunia D

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Recent RNA interference screens have identified several proteins that are essential for store-operated Ca(2+) influx and Ca(2+) release-activated Ca(2+) (CRAC) channel activity in Drosophila and in mammals, including the transmembrane proteins Stim...

Authors: Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD

Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways

Forkhead box (Fox)/winged-helix transcription factors regulate multiple aspects of immune responsiveness and Foxp3 is recognized as an essential functional marker of regulatory T cells. Herein we describe downstream signaling pathways targeted by...

Authors: Grant C, Oh U, Fugo K, Takenouchi N, Griffith C, Yao K, Newhook TE, Ratner L, Jacobson S

The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor

Unliganded thyroid hormone receptor (TR) actively represses transcription via the nuclear receptor corepressor (N-CoR)/histone deacetylase 3 (HDAC3) complex. Although transcriptional activation by liganded receptors involves chromatin remodeling, the...

Authors: Alenghat T, Yu J, Lazar MA

Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway

BACKGROUND: Recent genetic data in mouse and humans suggest that the chemokine receptors CCR2 and CX3CR1 are involved in atherogenesis; however, detailed molecular and cellular mechanisms have not been fully delineated. METHODS AND RESULTS: Here, we...

Authors: Barlic J, Zhang Y, Foley JF, Murphy PM

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