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4923 results sorted by

Signaling-dependent immobilization of acylated proteins in the inner monolayer of the plasma membrane

Phospholipids play a critical role in the recruitment and activation of several adaptors and effectors during phagocytosis. Changes in lipid metabolism during phagocytosis are restricted to the phagocytic cup, the area of the plasmalemma lining the...
Authors: Corbett-Nelson EF, Mason D, Marshall JG, Collette Y, Grinstein S

Constitutively activated FLT3 phosphorylates BAD partially through Pim-1

Constitutively activating internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) play an important role in leukaemogenesis and their presence is associated with a poor prognosis in acute myeloid...
Authors: Kim KT, Levis M, Small D

Interactions between c-Jun, Nuclear Factor-1 and JC Virus promoter sequences: Implications for viral tropism

The infectious cycle of the human polyomavirus JC (JCV) is ultimately regulated in cellular nuclei at the level of viral protein expression and genomic replication. Such activity is prompted by interactions between variant nucleotide sequences within...
Authors: Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO

Expression of Nef Downregulates CXCR4, the Major Coreceptor of Human Immunodeficiency Virus, From the Surface of Target Cells and Thereby Enhances Resistance to Superinfection

Lentiviral Nef proteins are key factors for pathogenesis and are known to downregulate functionally important molecules, including CD4 and major histocompatibility complex class I (MHC-I), from the surfaces of infected cells. Recently, we...
Authors: Venzke S, Michel N, Allespach I, Fackler OT, Keppler OT

Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis

Divisions of Dermatology and Medical Oncology, Department of Internal Medicine, Department of Pathology and Immunology, and Department of Medicine and Cell Biology, Washington University School of Medicine, St. Louis, Missouri. Melanoma is one of...
Authors: Gao L, Feng Y, Bowers R, Becker-Hapak M, Gardner J, Council L, Linette G, Zhao H, Cornelius LA

Targeting Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in the Mutant (V600E) B-Raf Signaling Cascade Effectively Inhibits Melanoma Lung Metastases

Malignant melanoma has a high propensity for metastatic spread, making it the most deadly form of skin cancer. B-RAF has been identified as the most mutated gene in these invasive cells and therefore an attractive therapeutic target. However, for...
Authors: Sharma A, Tran MA, Liang S, Sharma AK, Amin S, Smith CD, Dong C, Robertson GP

Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity

Emerging evidence suggests that alpha-synuclein (alpha-syn), which is traditionally thought to have a pathophysiological role in neurodegenerative diseases, can have neuroprotective effects. This study aimed to investigate whether endogenous...
Authors: Leng Y, Chuang DM

The Role of the NADPH Oxidase Complex, p38 MAPK and Akt in Regulating Human Monocyte/Macrophage Survival

The Role of the NADPH Oxidase Complex, p38 MAPK, and Akt in Regulating Human Monocyte/Macrophage Survival. Wang Y, Zeigler MM, Lam GK, Hunter MM-CSF induces PI 3-kinase activation, resulting in reactive oxygen species (ROS) production. Previously,...
Authors: Wang Y, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, Tridandapani SV, Sen CK, Marsh CB

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

Glucose-stimulated insulin secretion (GSIS) from pancreatic islet beta-cells is central to control of mammalian fuel homeostasis. Glucose metabolism mediates GSIS in part via ATP-regulated K(+) (K(ATP)) channels, but multiple lines of evidence...
Authors: Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB,...

Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells

CDCP1, a novel stem cell marker, is expressed in hematopoietic cell line K562 but not in Jurkat. When CDCP1 promoter was transfected exogenously, Jurkat showed comparable promoter activity with K562, suggesting that the factor to enhance...
Authors: Kimura H, Morii E, Ikeda JI, Ezoe S, Xu JX, Nakamichi N, Tomita Y, Shibayama H, Kanakura Y, Aozasa...