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4863 results sorted by

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1

The human immunodeficiency virus type 1 (HIV-1) pathogenicity factor Nef increases viral replication in vivo. In immortalized cell lines, Nef affects the cell surface levels of multiple receptors and signal transduction pathways. Resting CD4(+) T...
Authors: Keppler OT, Tibroni N, Venzke S, Rauch S and Fackler OT
SST Peer Reviewed

Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells

KBM5 cells, derived from a patient with blast crisis Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML), and imatinib-resistant KBM5 (KBM5-STI571) cells were found to express high levels of survivin. Inhibition of Bcr-Abl by...
Authors: Carter BZ, Mak D, Schober WD, Cabreira-Hansen M, Beran M, McQueen T, Chen W, and Andreeff M

Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes

The lateral mobility of individual murine polyoma virus-like particles (VLPs) bound to live cells and artificial lipid bilayers was studied by single fluorescent particle tracking using total internal reflection fluorescence microscopy. The particle...
Authors: Ewers H, Smith AE, Sbalzarini IF, Lilie H, Koumoutsakos P and Helenius A

alpha4 beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the 4-cytoplasmic domain

The capacity of integrins to mediate adhesiveness is modulated by their cytoplasmic associations. In this study, we describe a novel mechanism by which alpha(4)-integrin adhesiveness is regulated by the cytoskeletal adaptor paxillin. A mutation of...
Authors: Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V,...

Olig2 overexpression induces the in vitro differentiation of neural stem cells into mature oligodendrocytes

Differentiation induction of neural stem cells (NSCs) into oligodendrocytes during embryogenesis is the result of a complex interaction between local induction factors and intracellular transcription factors. At the early stage of differentiation, in...
Authors: Copray S, Balasubramaniyan V, Levenga J, de Bruijn J, Liem R and Boddeke E

A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death

Like anti-Fas monoclonal antibodies, some monoclonal antibodies against tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors have tumoricidal activity too. In this article we report a novel mouse anti-human DR5 monoclonal...
Authors: Guo Y, Chen C, Zheng Y, Zhang J, Tao X, Liu S, Zheng D and Liu Y

Efficient nonviral gene delivery into primary lymphocytes from rats and mice

Efficient nonviral gene delivery into primary lymphocytes from rats and mice. Goffinet C, Keppler OT. A rapid method for efficient gene delivery into primary rodent lymphocytes would greatly facilitate the study of signaling and metabolic...
Authors: Goffinet C and Keppler OT
SST Peer Reviewed

Tumor Suppressor p53 Binds with High Affinity to CTG{middle dot}CAG Trinucleotide Repeats and Induces Topological Alterations in Mismatched Duplexes

DNA binding is central to the ability of p53 to function as a tumor suppressor. In line with the remarkable functional versatility of p53, which can act on DNA as a transcription, repair, recombination, replication, and chromatin accessibility...
Authors: Walter K, Warnecke G, Bowater R, Deppert W and Kim EL

A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA transcripts. Although the spatial and temporal patterning of miRNA expression is tightly controlled, little is known about signals that induce their...
Authors: Vo N, Klein ME, Varlamova O, Keller DM, Yamamoto T, Goodman RH and Impey S
SST Peer Reviewed

IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells

IL-21 is a recently described cytokine, produced by activated Th cells, that shares significant homology with members of the IL-2 family of cytokines. IL-21 mediates its biological effects via the IL-21R in conjunction with the common receptor...
Authors: Burgess SJ, Marusina AI, Pathmanathan I, Borrego F and Coligan JE
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