Search Results

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate

BACE is a transmembrane protease with beta-secretase activity that cleaves the amyloid precursor protein (APP). After BACE cleavage, APP becomes a substrate for gamma-secretase, leading to release of amyloid-beta peptide (Abeta), which accumulates in...

Authors: von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT,...

Human FK506 binding protein 65 is associated with colorectal cancer

We initiated the present study to identify new genes associated with colorectal cancer. In a previously published microarray study an EST (W80763), later identified as the gene hFKBP10 (NM_021939), was found to be strongly expressed in tumors while...

Authors: Olesen SH, Christensen LL, Sorensen FB, Cabezon T, Laurberg S, Orntoft TF and Birkenkamp-Demtroder...

Measles virus interacts with and alters signal transduction in T-cell lipid rafts

By a contact-dependent surface interaction, the measles virus (MV) glycoprotein complex induces a pronounced inhibition of T-cell proliferation. We now show that MV directly interacts with glycosphingolipid-enriched membrane microdomains on human...

Authors: Avota E, Muller N, Klett M and Schneider-Schaulies S

Connexin43 associated with an N-cadherin containing multi-protein complex is required for gap junction formation in NIH3T3 cells

Previous studies have indicated an intimate linkage between gap junction and adherens junction formation. It was suggested this could reflect the close membrane-membrane apposition required for junction formation. In NIH3T3 cells, we observed the...

Authors: Wei CJ, Francis R, Xu X and Lo CW

A local coupling model and compass parameter for eukaryotic chemotaxis

Chemotaxis is a cellular sensing mechanism that guides immune cells to sites of infection and leads fibroblasts to sites of injury. Here, we show in migrating primary dendritic cells and fibroblasts that the leading edge is not a uniform signaling...

Authors: Arrieumerlou C and Meyer T

Nucleofection: a new, highly efficient transfection method for primary human keratinocytes

Transfection is an essential tool for numerous in vitro applications including studies of gene expression, promoter analysis, and intracellular signaling pathways and also for therapeutic strategies such as tissue engineering and gene therapy....

Authors: Distler JH, Jungel A, Kurowska-Stolarska M, Michel BA, Gay RE, Gay S and Distler O

SST Peer Reviewed

Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer

Molecular events underlying the progression of malignant tumors through the surrounding tissue are largely mediated by membrane-bound adhesion molecules. Basal-cell adhesion molecule (B-CAM), a 90-kDa laminin receptor of the immunoglobulin...

Authors: Drewniok C, Wienrich BG, Schon M, Ulrich J, Zen Q, Telen MJ, Hartig RJ, Wieland I, Gollnick H and...

Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations

Activation of mitogen-activated protein kinase (MAPK) occurs in response to various growth stimulating signals and as a result of activating mutations of the upstream regulators, KRAS and BRAF, which can be found in many types of human cancer. To...

Authors: Pohl G, Ho CL, Kurman RJ, Bristow R, Wang TL and Shih IeM

Apoptosis of the dermal papilla cells of hair follicle associated with the expression of gene HSPCO16 in vitro

The epithelial-mesenchymal interactions have an important role in the folliculomorphogenesis and mature hair follicle cycling. The dermal papilla, a dense aggregate of specialized dermis-derived stromal cells located at the bottom of the hair...

Authors: Yang WB, Hao F, Song ZQ, Yang XC, Ni B

Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation

cAMP-mediated signaling potentiates glucocorticoid-mediated apoptosis in lymphoid cells, but an effective means by which to take advantage of this observation in the treatment of lymphoid malignancies has not been identified. The primary objective of...

Authors: Tiwari S, Dong H, Kim EJ, Weintraub L, Epstein PM and Lerner A

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