Search Results

HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization

We investigated the role of acetylated microtubules in the antigen-specific interaction of T helper and antigen-presenting cells (APCs). In T cells, acetylated microtubules concentrated at contact site with APCs, surrounding clusters of CD3 and...

Authors: Serrador JM, Cabrero JR, Sancho D, Mittelbrunn M, Urzainqui A and Sanchez-Madrid F

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit...

Authors: Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T,...

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)

Secretion of cytolytic granules content at the immunological synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface,...

Authors: Feldmann J, Callebaut I, Raposo G, Certain S, Bacq D, Dumont C, Lambert N, Ouachee-Chardin M,...

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6

Mammalian cells express several transcription factors embedded in the endoplasmic reticulum (ER) as transmembrane proteins that are activated by proteolysis, and two types of these proteins have been extensively investigated. One type comprises the...

Authors: Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M and Mori K

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

The Bcl-2 family proteins are key regulators of apoptosis in human diseases and cancers. Though known to block apoptosis, Bcl-2 promotes cell death through an undefined mechanism. Here, we show that Bcl-2 interacts with orphan nuclear receptor Nur77...

Authors: Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC and Zhang XK

Inhibition of constitutive NF-kappaB activation in mantle cell lymphoma B cell lead to induction of cell cycle arrest and apoptosis

Constitutive activation of the NF-kappaB has been documented to be involved in the pathogenesis of many human malignancies, including hemopoietic neoplasms. In this study, we examined the status of NF-kappaB in two non-Hodgkin's lymphoma cell lines...

Authors: Pham LV, Tamayo AT, Yoshimura LC, Lo P and Ford RJ

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HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

Inhibition of constitutive NF-kappaB activation in mantle cell lymphoma B cell lead to induction of cell cycle arrest and apoptosis

Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death

The immunosuppressant rapamycin represses human immunodeficiency virus type 1 replication

Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells

A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons