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Old World Arenavirus Infection Interferes with the Expression of Functional alpha-Dystroglycan in the Host Cell

alpha-Dystroglycan (alpha-DG) is an important cellular receptor for extracellular matrix (ECM) proteins as well as the Old World arenaviruses lymphocytic choriomeningitis virus (LCMV) and the human pathogenic Lassa fever virus (LFV). Specific...

Authors: Rojek JM, Campbell KP, Oldstone MB, Kunz S

SST Peer Reviewed

PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development

In our previous study, we identified RICS, a novel beta-catenin-interacting protein with the GAP activity toward Cdc42 and Rac1, and found that RICS plays an important role in the regulation of neural functions, including postsynaptic NMDA signaling...

Authors: Hayashi T, Okabe T, Nasu-Nishimura Y, Sakaue F, Ohwada S, Matsuura K, Akiyama T, Nakamura T

Involvement of Rho kinase in endothelial barrier maintenance

OBJECTIVE: Rho kinase mediates vascular leakage caused by many vasoactive agents including thrombin. Enhanced Rho kinase activity induces endothelial barrier dysfunction by a contractile mechanism via inactivation of Myosin Phosphatase (MP). Here, we...

Authors: van Nieuw Amerongen GP, Beckers CM, Achekar ID, Zeeman S, Musters RJ, van Hinsbergh VW

Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed-lineage K3

Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase member that activates the c-Jun N-terminal kinase (JNK) pathway. Aberrant activation of MLK3 has been implicated in neurodegenerative diseases. Similarly, glycogen...

Authors: Mishra R, Barthwal MK, Sondarva G, Rana B, Wong L, Chatterjee M, Woodgett JR, Rana A

Snapin, a new regulator of receptor signaling, augments alpha 1A-adrenoceptor-operated calcium influx through TRPC6

Activation of G(q)-protein-coupled receptors, including the alpha(1A)-adrenoceptor (alpha(1A)-AR), causes a sustained Ca(2+) influx via receptor-operated Ca(2+) (ROC) channels, following the transient release of intracellular Ca(2+). Transient...

Authors: Suzuki F, Morishima S, Tanaka T, Muramatsu I

SST Peer Reviewed

Lymphatic reprogramming of micro vascular endothelial cells by CEA-related Cell Adhesion Molecule-1 via interaction with VEGFR-3 and Prox1

Here, we demonstrate that CEACAM1 is expressed and co-localized with podoplanin in lymphatic endothelial cells (LECs) of tumor but not of normal tissue. CEACAM1 overexpression in HDMECs results in a significant increase of podoplanin positive cells...

Authors: Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach JH, Loges S, Kilic E,...

PDGF Synergistically Enhances IFN--Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV Dementia

There is increasing cumulative evidence that activated mononuclear phagocytes (macrophages/microglia) releasing inflammatory mediators in the CNS are a better correlate of HIV-associated dementia (HAD) than the actual viral load in the brain. Earlier...

Authors: Dhillon NK, Peng F, Ransohoff RM, Buch S

T Cells Express 7-Nicotinic Acetylcholine Receptor Subunits That Require a Functional TCR and Leukocyte-Specific Protein Tyrosine Kinase for Nicotine-Induced Ca2+ Response

Acute and chronic effects of nicotine on the immune system are usually opposite; acute treatment stimulates while chronic nicotine suppresses immune and inflammatory responses. Nicotine acutely raises intracellular calcium ([Ca(2+)](i)) in T cells,...

Authors: Razani-Boroujerdi S, Boyd RT, DÜ¡vila-GarcÜa MI, Nandi JS, Mishra NC, Singh SP, Pena-Philippides...

Protein Phosphatase 2A Plays an Important Role in Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12-Mediated Migration and Adhesion of CD34+ Cells

Migration of hemopoietic stem and progenitor cells (HSPC) is required for homing to bone marrow following transplantation. Therefore, it is critical to understand signals underlying directional movement of HSPC. Stromal cell-derived factor-1...

Authors: Basu S, Ray NT, Atkinson SJ, Broxmeyer HE

SST Peer Reviewed

Mechanical Stretch Inhibits Oxidized Low Density Lipoprotein-induced Apoptosis in Vascular Smooth Muscle Cells by Up-regulating Integrin alphaVbeta3 and Stablization of PINCH-1

To determine the mechanisms involved in regulating the balance between apoptosis and survival in vascular smooth muscle cells (VSMC), we studied anti-apoptotic stimuli that can counteract pro-apoptotic events in the process of early atherosclerotic...

Authors: Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM, Du J

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Old World Arenavirus Infection Interferes with the Expression of Functional alpha-Dystroglycan in the Host Cell

PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development

Involvement of Rho kinase in endothelial barrier maintenance

Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed-lineage K3

Snapin, a new regulator of receptor signaling, augments alpha 1A-adrenoceptor-operated calcium influx through TRPC6

Lymphatic reprogramming of micro vascular endothelial cells by CEA-related Cell Adhesion Molecule-1 via interaction with VEGFR-3 and Prox1

PDGF Synergistically Enhances IFN--Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV Dementia

T Cells Express 7-Nicotinic Acetylcholine Receptor Subunits That Require a Functional TCR and Leukocyte-Specific Protein Tyrosine Kinase for Nicotine-Induced Ca2+ Response

Protein Phosphatase 2A Plays an Important Role in Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12-Mediated Migration and Adhesion of CD34+ Cells

Mechanical Stretch Inhibits Oxidized Low Density Lipoprotein-induced Apoptosis in Vascular Smooth Muscle Cells by Up-regulating Integrin alphaVbeta3 and Stablization of PINCH-1