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Epstein-barr virus lytic infection is required for efficient production of the angiogenesis factor vascular endothelial growth factor in lymphoblastoid cell lines

Although Epstein-Barr virus (EBV)-associated malignancies are primarily composed of cells with one of the latent forms of EBV infection, a small subset of tumor cells containing the lytic form of infection is often observed. Whether the rare...

Authors: Hong GK, Kumar P, Wang L, Damania B, Gulley ML, Delecluse HJ, Polverini PJ and Kenney SC

Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression

Downstream Regulatory Element Antagonist Modulator (DREAM) is a Ca(2+)-dependent transcriptional repressor expressed in the brain, thyroid gland and thymus. Here, we analyzed the function of DREAM and the related protein KChIP-2 in the immune system...

Authors: Savignac M, Pintado B, Gutierrez-Adan A, Palczewska M, Mellstrom B and Naranjo JR

The Cyclic AMP Response Element Modulator Regulates Transcription of the TCR -Chain

Systemic lupus erythematosus T cells display decreased amounts of TCR zeta mRNA that results in part from limited binding of the transcriptional enhancer Elf-1 to the TCR zeta promoter. We have identified a new cis-binding site for the cAMP response...

Authors: Tenbrock K, Kyttaris VC, Ahlmann M, Ehrchen JM, Tolnay M, Melkonyan H, Mawrin C, Roth J, Sorg C,...

Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in LPS-stimulated macrophages

Inflammatory lipid mediators such as prostaglandins and leukotrienes play crucial roles in the pathogenesis of bacterial lipopolysaccharide (LPS)-induced inflammation. Cytosolic phospholipase A(2) (cPLA(2)) is a key enzyme in the generation of...

Authors: Qi HY and Shelhamer JH

Receptor-type Protein-tyrosine Phosphatase- Regulates Epidermal Growth Factor Receptor Function

Epidermal growth factor receptor (EGFR), the prototypic receptor protein tyrosine kinase, is a major regulator of growth and survival for many epithelial cell types. We report here that receptor-type protein-tyrosine phosphatase-kappa (RPTP-kappa)...

Authors: Xu Y, Tan LJ, Grachtchouk V, Voorhees JJ and Fisher GJ

STIM1 is a Ca(2+) sensor that activates CRAC channels and migrates from the Ca(2+) store to the plasma membrane

As the sole Ca(2+) entry mechanism in a variety of non-excitable cells, store-operated calcium (SOC) influx is important in Ca(2+) signalling and many other cellular processes. A calcium-release-activated calcium (CRAC) channel in T lymphocytes is...

Authors: Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA and Cahalan MD

TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor

TRAF6 is an E3 ubiquitin ligase that mediates signaling from members of the tumor necrosis factor and Toll-like receptor superfamilies, including the p75 neurotrophin receptor. Recently, TRAF6 was shown to bind to another p75 cytoplasmic interactor,...

Authors: Geetha T, Kenchappa RS, Wooten MW and Carter BD

Sphingosine Kinase 1 Is a Negative Regulator of CD4+ Th1 Cells

CD4(+) Th1 cells produce IFN-gamma, TNF-alpha, and IL-2. These Th1 cytokines play critical roles in both protective immunity and inflammatory responses. In this study we report that sphingosine kinase 1 (SPHK1), but not SPHK2, is highly expressed in...

Authors: Yang J, Castle BE, Hanidu A, Stevens L, Yu Y, Li X, Stearns C, Papov V, Rajotte D and Li J

The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer

Binding of antigen to the B cell antigen receptor (BCR) triggers signaling that ultimately leads to B cell activation. Using quantitative fluorescence resonance energy transfer imaging, we provide evidence here that the BCR is a monomer on the...

Authors: Tolar P, Sohn HW and Pierce SK

Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia

Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3, and MCT4 form heterodimeric complexes with the cell surface glycoprotein CD147 and exhibit tissue-specific polarized distributions that are essential for maintaining lactate and pH...

Authors: Deora AA, Philp N, Hu J, Bok D and Rodriguez-Boulan E

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