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The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells

The role of the presumptive phosphatidylserine receptor (PSR) in the recognition and engulfment of apoptotic cells, and the anti-inflammatory response they exert, has been of great interest. Genetic deficiency of PSR in the mouse is lethal...
Authors: Mitchell JE, Cvetanovic M, Tibrewal N, Patel V, Colamonici OR, Li MO, Flavell RA, Levine JS, Birge...

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Perifosine is a synthetic novel alkylphospholipid, a new class of anti-tumor agents which targets cell membranes and inhibits Akt activation. Here we show that baseline phosphorylation of Akt in MM cells is completely inhibited by Perifosine in a...
Authors: Hideshima T, Catley L, Yasui H, Ishitsuka K, Raje N, Mitsiades C, Podar K, Munshi NC, Chauhan D,...

P-selectin binds to the D'-D3 domains of von Willebrand factor in Weibel-Palade bodies

It has recently been shown that the ultralarge platelet-recruiting VWF strings formed immediately at exocytosis from endothelial cells may be anchored to the cell surface by an interaction with the integral membrane protein P-selectin. This finding...
Authors: Michaux G, Pullen TJ, Haberichter SL and Cutler DF

Astrocyte-specific Expression of the 1-Antichymotrypsin and Glial Fibrillary Acidic Protein Genes Requires Activator Protein-1

An amyloid-associated serine proteinase inhibitor (serpin), alpha(1)-antichymotrypsin (ACT), is encoded by a gene located within the distal serpin subcluster on human chromosome 14q32.1. The expression of these distal serpin genes is determined by...
Authors: Gopalan SM, Wilczynska KM, Konik BS, Bryan L and Kordula T

The brain-specific double-stranded RNA-binding protein Staufen2 is required for dendritic spine morphogenesis

Mammalian Staufen2 (Stau2) is a member of the double-stranded RNA-binding protein family. Its expression is largely restricted to the brain. It is thought to play a role in the delivery of RNA to dendrites of polarized neurons. To investigate the...
Authors: Goetze B, Tuebing F, Xie Y, Dorostkar MM, Thomas S, Pehl U, Boehm S, Macchi P and Kiebler MA

The Wnt-inducible transcription factor twist1 inhibits chondrogenesis

Wnt signaling is essential for many developmental processes including skeletogenesis. To investigate the effects of Wnt signaling during skeletogenesis we studied the effects of Wnt on cultured chondrocytic cells and differentiating limb bud...
Authors: Reinhold MI, Kapadia RM, Liao Z and Naski MC

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

Understanding the molecular mechanisms that regulate cellular proliferation and differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class of regulatory RNAs of approximately 22 nucleotides that post-transcriptionally...
Authors: Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL and Wang DZ

Phase coexistence and connectivity in the apical membrane of polarized epithelial cells

Although it is well described in model membranes, little is known about phase separation in biological membranes. Here, we provide evidence for a coexistence of at least two different lipid bilayer phases in the apical plasma membrane of epithelial...
Authors: Meder D, Moreno MJ, Verkade P, Vaz WL and Simons K

The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

BRIP1 (also called BACH1) is a DEAH helicase that interacts with the BRCT domain of BRCA1 (refs. 1-6) and has an important role in BRCA1-dependent DNA repair and checkpoint functions. We cloned the chicken ortholog of BRIP1 and established a...
Authors: Bridge WL, Vandenberg CJ, Franklin RJ and Hiom K

Elevated expression of C10orf3 (chromosome 10 open reading frame 3) is involved in the growth of human colon tumor

After analysing gene-expression profiles of colon cancers on a cDNA microarray containing cDNAs corresponding to 23 040 human genes, we focused on a gene annotated as C10orf3 (chromosome 10 open reading frame 3), whose expression was elevated in...
Authors: Sakai M, Shimokawa T, Kobayashi T, Matsushima S, Yamada Y, Nakamura Y and Furukawa Y