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4670 results sorted by

The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury

Schwann cells undergo phenotypic modulation in peripheral nerve injury. In the adult rodent, Schwann cells are resistant to death-promoting challenges. The responsible receptors and signaling pathways are incompletely understood. In this study, we...
Authors: Campana WM, Li X, Dragojlovic N, Janes J, Gaultier A, Gonias SL
SST Peer Reviewed

Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth

Recent evidence has implicated dynein and its regulatory factors dynactin and LIS1 in neuronal and non-neuronal cell migration. In the current study we sought to test whether effects on neuronal cell motility might reflect, in part, a role for these...
Authors: Grabham PW, Seale GE, Bennecib M, Goldberg DJ, Vallee RB
SST Peer Reviewed

DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412

The presence of internal tandem duplications (ITD) mutations in the FMS-like tyrosine kinase 3 (FLT3) receptor influences the risk of relapse in acute myeloid leukaemia (AML). We have investigated DNA repair in FLT3-ITD and wild-type (WT) cells....
Authors: Seedhouse CH, Hunter HM, Lloyd-Lewis B, Massip AM, Pallis M, Carter GI, Grundy M, Shang S, Russell...

ATF2 impairs glucocorticoid receptor-mediated transactivation in human CD8+ T cells

Chronic inflammatory diseases often have residual CD8(+) T cell infiltration despite treatment with systemic corticosteroids suggesting divergent steroid responses between CD4(+) vs. CD8(+) cells. To examine steroid sensitivity, dexamethasone...
Authors: Li LB, Leung DY, Strand MJ, Goleva E

Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins

In mammalian cells, DNA methylation is associated with heritable and stable gene repression, mediated in part by methyl-CpG-binding domain (MBD) proteins that recruit corepressors to modify chromatin. MBD1 protein, a member of the MBD family, forms a...
Authors: Lyst MJ, Nan X, Stancheva I

Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-I expression

The Bax inhibitor-1 (BI-1) is an anti-apoptotic protein that is located in ER membranes and protects cells from ER stress-induced apoptosis. The ER is associated with generation of reactive oxygen species (ROS) through oxidative protein folding. This...
Authors: Lee GH, Kim HK, Chae SW, Kim DS, Ha KC, Mike C, Kress C, Reed JC, Kim HR, Chae HJ

Histone Deacetylase Inhibitors Sensitize Prostate Cancer Cells to Agents that Produce DNA Double-Strand Breaks by Targeting Ku70 Acetylation

This study reports a histone deacetylation-independent mechanism whereby histone deacetylase (HDAC) inhibitors sensitize prostate cancer cells to DNA-damaging agents by targeting Ku70 acetylation. Ku70 represents a crucial component of the...
Authors: Chen CS, Wang YC, Yang HC, Huang PH, Kulp SK, Yang CC, Lu YS, Matsuyama S, Chen CY, Chen CS

Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has emerged as a promising prognostic marker and putative therapeutic target in prostate cancer (PCa). However, the mechanisms of prostate-specific regulation and...
Authors: Bidaux G, Flourakis M, Thebault S, Zholos A, Beck B, Gkika D, Roudbaraki M, Bonnal JL, Mauroy B,...

Delta-like 4 induces notch signaling in macrophages: implications for inflammation

BACKGROUND: Activated macrophages contribute to the pathogenesis of inflammatory diseases such as atherosclerosis. Although Notch signaling participates in various aspects of immunity, its role in macrophage activation remains undetermined. METHODS...
Authors: Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC,...

Corticosteroid Inhibition of Growth-Related Oncogene Protein- via Mitogen-Activated Kinase Phosphatase-1 in Airway Smooth Muscle Cells

Expression of the inflammatory chemokine, growth-related oncogene protein-alpha (GRO-alpha), from airway smooth muscle cells (ASMC) is regulated by pathways involving NF-kappaB and MAPK activation. We determined the effects of dexamethasone on...
Authors: Issa R, Xie S, Khorasani N, Sukkar M, Adcock IM, Lee KY, Chung KF
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