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Prox1 Promotes Lineage-specific Expression of Fibroblast Growth Factor (FGF) Receptor-3 in Lymphatic Endothelium: A Role for FGF Signaling in Lymphangiogenesis

Fibroblast growth factors play important roles in angiogenesis, but their functions in lymphangiogenesis remain poorly understood. The homeodomain transcription factor Prox1 is essential for development of the lymphatic system by specifying lymphatic...

Authors: Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A,...

Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity

Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G), a cytidine deaminase, is a recently recognized innate intracellular protein with lethal activity against human immunodeficiency virus (HIV). Packaged into progeny virions,...

Authors: Peng G, Lei KJ, Jin W, Greenwell-Wild T and Wahl SM

Overexpression of bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans

Background/Aims. Myofibroblast - like cells originating from the activation of hepatic stellate cells (HSC/MFs) play a key role in liver fibrosis, a potentially reversible process that may rely on induction of HSC/MFs apoptosis. While this...

Authors: Novo E, Marra F, Zamara E, Valfre di Bonzo L, Monitillo L, Cannito S, Petrai I, Mazzocca A, Bonacchi...

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte derived dendritic cells

SLAM (Signaling Lymphocyte Activation Molecule, CD150 or SLAMF1) is a self-ligand receptor on the surface of activated T- and B-lymphocytes, macrophages and dendritic cells (DCs). Here we examine the effect of SLAM/SLAM interactions on CD40L-induced...

Authors: Rethi B, Gogolak P, Szatmari I, Veres A, Erdos E, Nagy L, Rajnavolgyi E, Terhorst C, Lanyi A

Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain

Agenesis of the corpus callosum (CC) is a rare birth defect that occurs in isolated conditions and in combination with other developmental cerebral abnormalities. Recent identification of families of growth and guidance molecules has generated...

Authors: Mendes SW, Henkemeyer M and Liebl DJ

Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology

Oligodendrocytes form an insulating multilamellar structure of compact myelin around axons, thereby allowing rapid propagation of action potentials. Despite the considerable clinical importance of myelination, little is known about the molecular...

Authors: Brockschnieder D, Sabanay H, Riethmacher D and Peles E

Angiotensin II Stimulates Transcription of Insulin-like Growth Factor 1 Receptor in Vascular Smooth Muscle Cells: Role of NF-B

Increased expression of the insulin-like growth factor 1 receptor (IGF-1R) is associated with proliferation and survival of vascular smooth muscle cells (VSMCs). In cultured VSMCs, we reported that Angiotensin II (Ang II) increases transcription and...

Authors: Ma Y, Zhang L, Peng T, Cheng J, Taneja S, Zhang J, Delafontaine P and Du J

HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells

Human T cell leukemia virus type I (HTLV-I) causes adult T cell leukemia (ATL) in 2-5% of carriers after a long latent period. An HTLV-I encoded protein, Tax, induces proliferation and inhibits apoptosis, resulting in clonal proliferation of infected...

Authors: Satou Y, Yasunaga J, Yoshida M, Matsuoka M

Preligand assembly domain-mediated ligand- independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a cytokine with potential therapeutic value against cancers because of its selective cytotoxicity to many transformed, but not normal, cells. The "decoy receptors" TRAIL-R3...

Authors: Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ and Chan FK

Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian xenopus laevis and its involvement in hyaluronan synthesis

UDP-glucose dehydrogenase (UGDH) supplies the cell with UDP-glucuronic acid, a precursor of glycosaminoglycan and proteoglycan synthesis. In this study, we report the cloning and the characterization of the UGDH from the amphibian Xenopus laevis that...

Authors: Vigetti D, Ori M, Viola M, Genasetti A, Karousou E, Rizzi M, Pallotti F, Nardi I, Hascall VC, De...

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