Search Results

Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis

We have tested the idea that calcineurin, a calcium-dependent phosphatase that is critical for activating cytokine gene expression in helper T cells, plays a role in lytic granule exocytosis in cytotoxic T lymphocytes (CTLs). We used TALL-104 human...

Authors: Grybko MJ, Bartnik JP, Wurth GA, Pores-Fernando AT, Zweifach A

Retinoic Acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells

CD1d belongs to a group of nonclassical antigen-presenting molecules that present glycolipid antigens and thereby activate natural killer T (NKT) cells, a subset of bifunctional T cells. Little is known so far regarding the expression and physiologic...

Authors: Chen Q, Ross AC

Cytokine-Independent Upregulation of MDA5 in Viral Infection

The RNA helicases RIG-I and MDA5 detect virus infection of dendritic cells (DCs) leading to cytokine induction. Maximal sensitivity for virus detection by these helicases is obtained after their upregulation, which is thought to occur primarily...

Authors: Yount JS, Moran TM, Lopez CB

Live cell imaging of phagosome maturation in Staphylococcus aureus infected human endothelial cells: small colony variants are able to survive in lysosomes

Small colony variants (SCVs) of Staphylococcus aureus have been proposed to persist within vascular endothelium, thereby sustaining chronic infections. To identify the intracellular SCV location we infected primary human endothelial cells with...

Authors: Schroder A, Kland R, Peschel A, von Eiff C, Aepfelbacher M

The molecular mechanism of hepcidin-mediated ferroportin down-regulation

Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron or inflammation, binds to Fpn inducing its internalization and degradation. We show that after binding of hepcidin, Fpn is...

Authors: De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J

Vasoactive intestinal peptide transactivates the androgen receptor through a PKA-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells

Acquisition of androgen independence by prostate cancer is the key problem of prostate cancer progression. Vasoactive intestinal peptide (VIP), a neuropeptide, may act as a survival factor for prostate cancer cells under androgen deprivation....

Authors: Xie Y, Wolff DW, Lin MF, Tu Y

SST Peer Reviewed

Novel c-CBL and CBL-B ubiquitin ligase mutations in human acute myeloid leukemia

The CBL ubiquitin ligase targets a variety of activated tyrosine kinases (TK) for degradation. Many TKs are mutationally or autocrine-activated and/or often over-expressed at the mRNA and protein levels in acute leukemias. We hypothesized that CBL is...

Authors: Caligiuri MA, Briesewitz R, Yu J, Wang L, Wei M, Arnoczky KJ, Marburger TB, Wen J, Perrotti D,...

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression

CD56(high) acute myeloid leukemias (AMLs) have a poor prognosis but it has been unclear how CD56 expression is controlled and how it relates to clinical aggressiveness. We show here that CD56 expression on AML cells correlates with an abnormal...

Authors: Gattenloehner S, Chuvpilo S, Langebrake C, Reinhardt D, Muller-Hermelink HK, Serfling E, Vincent A,...

SST Peer Reviewed

Gene expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt's lymphoma cell lines and primary tumors

Burkitt lymphoma (BL) is a B-cell tumor whose characteristic gene aberration is the translocation t(8;14), which determines c-myc overexpression. Several genetic and epigenetic alterations, other than c-myc overexpression, have also been described in...

Authors: De Falco G, Leucci E, Lenze D, Piccaluga PP, Claudio PP, Onnis A, Cerino G, Nyagol J, Mwanda W,...

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF. MIF triggered G(alphai)- and...

Authors: Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng...

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