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4660 results sorted by

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

CD4+ T cell priming under T helper type I (T(H)1) or T(H)2 conditions gives rise to polarized cytokine gene expression. We found that in these conditions human naive T cells acquired stable histone hyperacetylation at either the Ifng or Il4 promoter....
Authors: Messi M, Giacchetto I, Nagata K, Lanzavecchia A, Natoli G and Sallusto F

Toll-like receptor signaling alters the expression of regulator of g protein signaling proteins in dendritic cells: implications for g protein-coupled receptor signaling

Conserved structural motifs on pathogens trigger pattern recognition receptors present on APCs such as dendritic cells (DCs). An important class of such receptors is the Toll-like receptors (TLRs). TLR signaling triggers a cascade of events in DCs...
Authors: Shi GX, Harrison K, Han SB, Moratz C and Kehrl JH

Analysis of intracellular storage and regulated secretion of three von Willebrands disease-causing variants of von Willebrand factor

The rapid exocytosis of von Willebrand factor (VWF) in response to vascular injury can be attributed to the fact that VWF is stored in the Weibel-Palade bodies (WPBs) of endothelial cells. We describe a system for examining the ability of VWF to...
Authors: Michaux G, Hewlett LJ, Messenger SL, Goodeve AC, Peake IR, Daly ME and Cutler DF

Cutting Edge: TGF-beta Induces a Regulatory Phenotype in CD4(+)CD25(-) T Cells through Foxp3 Induction and Down-Regulation of Smad7

CD4(+)CD25(+) regulatory cells are a subpopulation of T lymphocytes of thymic origin. However, recent data suggest an alternative commitment of regulatory T cells in the periphery, although the precise mechanism is unknown. In the present work, we...
Authors: Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR and Neurath MF

HAX-1, identified by differential display reverse transcription polyerase chain reaction, is overexpressed in lesional psoriasis

Psoriasis is a chronic inflammatory disease characterized by epidermal hyperplasia and an inflammatory infiltrate. The normal differentiation from basal to granular keratinocytes with subsequent apoptosis and cornification is disturbed in the...
Authors: Mirmohammadsadegh A, Tartler U, Michel G, Baer A, Walz M, Wolf R, Ruzicka T and Hengge UR

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

The unrestrained growth of tumor cells is generally attributed to mutations in essential growth control genes, but tumor cells are also influenced by signals from the environment. In multiple myeloma (MM), the factors and signals coming from the bone...
Authors: Derksen PWB, Tjin E, Meijer HP, Klok MD, Mac Gillavry HD, van Oers MHJ, Lokhorst HM, Bloem AC,...

Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism

The 'classical' NF-kappaB activation pathway proceeds via IkappaB kinase (IKK)-beta/gamma-mediated phosphorylation, induced ubiquitination and the degradation of small IkappaBs. An alternative, NF-kappaB-inducing kinase and IKK-alpha-dependent...
Authors: Mordmüller B, Krappmann D, Esen M, Wegener E and Scheidereit C

Brain development in mice lacking L1-L1 homophilic adhesion

A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at normal levels. In vitro experiments showed that L1-L1 homophilic...
Authors: Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P and...

Human parvovirus B19 nonstructural protein (NS1) induces cell cycle arrest at G1 phase

Human parvovirus B19 infects predominantly erythroid precursor cells, leading to inhibition of erythropoiesis. This erythroid cell damage is mediated by the viral nonstructural protein 1 (NS1) through an apoptotic mechanism. We previously...
Authors: Morita E, Nakashima A, Asao H, Sato H and Sugamura K

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure

Big mitogen-activated protein kinase 1 (BMK1), also known as ERK5, is a member of the MAPK family. Genetic ablation of BMK1 in mice leads to embryonic lethality, precluding the exploration of pathophysiological roles of BMK1 in adult mice. We...
Authors: Hayashi M, Kim SW, Imanaka-Yoshida K, Yoshida T, Abel ED, Eliceiri B, Yang Y, Ulevitch RJ and Lee...
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