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4785 results sorted by

Cross talk between engulfment receptors stabilin-2 and integrin avß5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes.

Efficient cell corpse clearance is critical for health in organisms. Apoptotic cells displaying phosphatidylserine (PS) are recognized by engulfment receptors and ingested through two conserved pathways. In one pathway, engulfment receptor...
Authors: Kim S1, Park SY, Kim SY, Bae DJ, Pyo JH, Hong M, Kim IS.

Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells.

Most cell membrane proteins are known or predicted to be glycosylated in eukaryotic organisms, where surface glycans are essential in many biological processes including cell development and differentiation. Nonetheless, the glycosylation on cell...
Authors: An HJ1, Gip P, Kim J, Wu S, Park KW, McVaugh CT, Schaffer DV, Bertozzi CR, Lebrilla CB.

Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes

We describe the potential of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence as a source of contrast for margin detection in commonly diagnosed breast cancer subtypes. Fluorescence intensity of PpIX in untreated and...
Authors: Millon SR1, Ostrander JH, Yazdanfar S, Brown JQ, Bender JE, Rajeha A, Ramanujam N.

Generation of breast cancer stem cells through epithelial-mesenchymal transition.

Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells....
Authors: Morel AP1, Lièvre M, Thomas C, Hinkal G, Ansieau S, Puisieux A.

Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia

Because natural killer (NK) cells kill tumor cells and combat infections, there is growing interest in adoptively transferring NK cells to hematopoietic stem cell recipients. Unfortunately, in humans, the activity of NK cells against Aspergillus...
Authors: Schmidt S1, Tramsen L, Hanisch M, Latgé JP, Huenecke S, Koehl U, Lehrnbecher T.

Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization.

LY573636-sodium (tasisulam) is a small molecule antitumor agent with a novel mechanism of action currently being investigated in a variety of human cancers. In vitro, tasisulam induced apoptosis via the intrinsic pathway, resulting in cytochrome c...
Authors: Meier T, Uhlik M, Chintharlapalli S, Dowless M, Van Horn R, Stewart J, Blosser W, Cook J, Young D,...
SST Peer Reviewed

Enhanced endothelial differentiation of adipose-derived stem cells by substrate nanotopography.

Adipose-derived stem cells (ADSCs) have great potential as a cell source for tissue engineering and regenerative medicine because they are easier to obtain, have lower donor-site morbidity and are available in larger numbers than stem cells harvested...
Authors: Shi Z, Neoh KG, Kang ET, Poh CK, Wang W.
SST Peer Reviewed

Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.

Altered T cell function in systemic lupus erythematosus (SLE) is determined by various molecular and cellular abnormalities, including increased IL-17 production. Recent evidence suggests a crucial role for signaling lymphocyte activation molecules...
Authors: Chatterjee M1, Rauen T, Kis-Toth K, Kyttaris VC, Hedrich CM, Terhorst C, Tsokos GC.

Notch signaling regulates mouse and human Th17 differentiation

Th17 cells are known to play a critical role in adaptive immune responses to several important extracellular pathogens. Additionally, Th17 cells are implicated in the pathogenesis of several autoimmune and inflammatory disorders as well as in cancer....
Authors: Keerthivasan S1, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I,...

Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes.

The roles of cholecystokinin 2 receptor (CCK2R) in numerous physiologic processes in the gastrointestinal tract and central nervous system are well documented. There has been some evidence that CCK2R alterations play a role in cancers, but the...
Authors: Willard MD, Lajiness ME, Wulur IH, Feng B, Swearingen ML, Uhlik MT, Kinzler KW, Velculescu VE,...
SST Peer Reviewed
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