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Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection

Malaria infection starts when sporozoites are transmitted to the mammalian host during a mosquito bite. Sporozoites enter the blood circulation, reach the liver and infect hepatocytes. The formation of a parasitophorous vacuole (PV), establishes...

Authors: Labaied M, Harupa A, Dumpit RF, Coppens I, Mikolajczak SA, Kappe SH

Cannabinoid receptor agonist induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest

We have recently shown that the expression levels of both cannabinoid receptors CB(1) and CB(2) are higher in human prostate cancer cells than in normal prostate epithelial cells, and treatment of LNCaP cells with WIN-55,212-2 (a mixed CB(1)/CB(2)...

Authors: Sarfaraz S, Afaq F, Adhami VM, Malik A, Mukhtar H

Evaluation of the Biological Activity of a GH Mutant (R77C) and its Impact on GH Responsiveness and Stature

Context and Objective: A single missense mutation in the GH-1 gene converting codon 77 from arginine (R) to cysteine (C) yields a mutant GH-R77C peptide, which was described as natural growth hormone antagonist. Design, Setting, Patients:...

Authors: Petkovic V, Besson A, Thevis M, Lochmatter D, Eblé A, Flück CE, Mullis PE

Developmental Switch from Prolonged Insulin Action to Increased Insulin Sensitivity in Protein Tyrosine Phosphatase 1B-Deficient Hepatocytes

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes. The purpose of this study was to evaluate the differences in insulin sensitivity between neonate and adult hepatocytes...

Authors: Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM

The localization and activity of sphingosine kinase 1 are coordinately-regulated with actin cytoskeletal dynamics in macrophages

The physiologic and pathologic functions of sphingosine kinase (SK)1 require translocation to specific membrane compartments. We tested the hypothesis that interactions with actin filaments regulate the localization of SK1 to membrane surfaces;...

Authors: Kusner DJ, Thompson CR, Melrose NA, Pitson SM, Obeid LM, Iyer SS

SST Peer Reviewed

C-Peptide Induces Smooth Muscle cell Proliferation - Involvement of Src-Kinase, Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase 1/2

Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest a potential causal role of C-peptide in atherogenesis by promoting monocyte and...

Authors: Walcher D, Babiak C, Poletek P, Rosenkranz S, Bach H, Betz S, Durst R, Grub M, Hombach V, Strong J,...

Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming

The use of recombinant tumor antigen proteins is a realistic approach for the development of generic cancer vaccines, but the potential of this type of vaccines to induce specific CD8(+) T cell responses, through in vivo cross-priming, has remained...

Authors: Valmori D, Souleimanian NE, Tosello V, Bhardwaj N, Adams S, O'neill D, Pavlick A, Escalon JB, Cruz...

NRAS mutation causes a human autoimmune lymphoproliferative syndrome

The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline...

Authors: Oliveira JB, Bidère N, Niemela JE, Zheng L, Sakai K, Nix CP, Danner RL, Barb J, Munson PJ, Puck JM,...

Functional genomic analysis of oligodendrocyte differentiation

To better understand the molecular mechanisms governing oligodendrocyte (OL) differentiation, we have used gene profiling to quantitatively analyze gene expression in synchronously differentiating OLs generated from pure oligodendrocyte precursor...

Authors: Dugas JC, Tai YC, Speed TP, Ngai J, Barres BA

SST Peer Reviewed

Vif counteracts a cyclophilin A-imposed inhibition of Simian immunodeficiency viruses in human cells

Vif is a primate lentiviral accessory protein that is crucial for viral infectivity. Vif counteracts the antiviral activity of host deaminases such as APOBEC3G and APOBEC3F. We now report a novel function of African green monkey simian...

Authors: Takeuchi H, Buckler-White A, Goila-Gaur R, Miyagi E, Khan MA, Opi S, Kao S, Sokolskaja E, Pertel T,...

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