Search Results

Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-ß1.

BACKGROUND: We have previously shown that transforming growth factor-beta (TGF-beta) impairs glucocorticoid (GC) function in pulmonary epithelial cell-lines. However, the signalling cascade leading to this impairment is unknown. In the present...

Authors: Keenan CR, Mok JS, Harris T, Xia Y, Salem S, Stewart AG

Potentiation of osteoclastogenesis by adipogenic conversion of bone marrow-derived mesenchymal stem cells.

Bone marrow-derived mesenchymal stem cells (BMSCs) are the indispensable component of the bone marrow, being the common precursors for adipocytes and osteoblasts. We show here that adipogenic differentiation resulted in increase in the production of...

Authors: Mori K, Suzuki K, Hozumi A, Goto H, Tomita M, Koseki H, Yamashita S, Osaki M

SST Peer Reviewed

The nitrated fatty acid 10-nitro-oleate attenuates allergic airway disease.

Asthma is a serious, growing problem worldwide. Inhaled steroids, the current standard therapy, are not always effective in this chronic inflammatory disease and can cause adverse effects. We tested the hypothesis that nitrated fatty acids (NFAs) may...

Authors: Reddy AT, Lakshmi SP, Dornadula S, Pinni S, Rampa DR, Reddy RC.

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

OBJECTIVE: The mechanistic link between Janus kinase (JAK) signaling and structural damage to arthritic joints in rheumatoid arthritis (RA) is poorly understood. This study was undertaken to investigate how selective inhibition of JAK with...

Authors: LaBranche TP, Jesson MI, Radi ZA, Storer CE, Guzova JA, Bonar SL, Thompson JM, Happa FA, Stewart ZS,...

SST Peer Reviewed

Systems approaches to modeling chronic mucosal inflammation.

The respiratory mucosa is a major coordinator of the inflammatory response in chronic airway diseases, including asthma and chronic obstructive pulmonary disease (COPD). Signals produced by the chronic inflammatory process induce epithelial...

Authors: Kalita M, Tian B, Gao B, Choudhary S, Wood TG, Carmical JR, Boldogh I, Mitra S, Minna JD, Brasier...

Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2\\\',7\\\'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer.

Evolution of reactive oxygen species (ROS), generated during the patho-physiological stress of nervous tissue, has been implicated in the etiology of several progressive human neurological disorders including Alzheimer's disease (AD) and amylotrophic...

Authors: Pogue AI, Jones BM, Bhattacharjee S, Percy ME, Zhao Y, Lukiw WJ

SST Peer Reviewed

A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets

Cancer/testis (CT) antigens are potential immunotherapeutic targets in cancer. However, the expression of particular antigens is limited to a subset of tumors of a given type. Thus, there is a need to identify antigens with complementary expression...

Authors: Taguchi A1, Taylor AD2, Rodriguez J3, Celiktas M4, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L,...

Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro.

The differentiation of mesenchymal stem cells (MSCs) into type II alveolar epithelial (AT II) cells in vivo and in vitro, is critical for reepithelization and recovery in acute lung injury (ALI), but the mechanisms responsible for differentiation are...

Authors: Liu AR, Liu L, Chen S, Yang Y, Zhao HJ, Liu L, Guo FM, Lu XM, Qiu HB.

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation.

Successful vascular healing after percutaneous coronary interventions is related to the inhibition of abnormal vascular smooth muscle cell proliferation and efficient re-endothelialization. In the search for vascular smooth muscle cell...

Authors: Mair CE, Liu R, Atanasov AG, Wimmer L, Nemetz-Fiedler D, Sider N, Heiss EH1, Mihovilovic MD, Dirsch...

SST Peer Reviewed

Initial observations on the effect of medium composition on the differentiation of murine embryonic stem cells to alveolar type II cells.

The pluripotency and high proliferative index of embryonic stem (ES) cells make them a good potential source of cells for tissue engineering purposes. We have shown that ES cells can be induced to differentiate in vitro into pulmonary epithelial...

Authors: Rippon HJ, Ali NN, Polak JM, Bishop AE.

Data Type

Category

Research Area

Platform

Topic

Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-ß1.

Potentiation of osteoclastogenesis by adipogenic conversion of bone marrow-derived mesenchymal stem cells.

The nitrated fatty acid 10-nitro-oleate attenuates allergic airway disease.

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

Systems approaches to modeling chronic mucosal inflammation.

Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2\\\',7\\\'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer.

A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets

Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro.

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation.

Initial observations on the effect of medium composition on the differentiation of murine embryonic stem cells to alveolar type II cells.