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Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced sp1 activity

Interleukin-21 (IL-21) plays important roles in regulating the immune response. IL-21 receptor (IL-21R) mRNA is expressed at a low level in human resting T cells but is rapidly induced by mitogenic stimulation. We now investigate the basis for IL21R...
Authors: Wu Z, Kim HP, Xue HH, Liu H, Zhao K and Leonard WJ

Cyclin e overexpression obstructs infiltrative behavior in breast cancer: a novel role reflected in the growth pattern of medullary breast cancers

Cell cycle deregulation is a prerequisite in tumor development and overexpression of cyclin E, a major G(1)-S regulator, is often observed in breast cancer and is further linked to poor prognosis. By overexpressing cyclin E in a...
Authors: Berglund P, Stighall M, Jirstrom K, Borgquist S, Sjolander A, Hedenfalk I and Landberg G

Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a multifunctional tumor suppressor, has been shown to play a regulatory role in cell migration. Dictyostelium discoideum cells lacking PTEN exhibited impaired migration toward...
Authors: Gao P, Wange RL, Zhang N, Oppenheim JJ and Howard OM

Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS

A member of the IFN regulatory factor (IRF) family of transcription factors, IRF-4 is expressed in lymphocytes and macrophage/dendritic cells. Studies using IRF-4-deficient mice have revealed the critical roles of IRF-4 in lymphocyte responses....
Authors: Honma K, Udono H, Kohno T, Yamamoto K, Ogawa A, Takemori T, Kumatori A, Suzuki S, Matsuyama T and...

Negative regulation of Toll-like-receptor signaling by IRF-4

The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and adaptive immune systems. TLR activation triggers the induction of downstream target genes, wherein the TLR-interacting adaptor...
Authors: Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T and Honda K

Immediate and delayed effects of e-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells

The invasion suppressor protein, E-cadherin, plays a central role in epithelial cell-cell adhesion. Loss of E-cadherin expression or function in various tumors of epithelial origin is associated with a more invasive phenotype. In this study, by...
Authors: Andersen H, Mejlvang J, Mahmood S, Gromova I, Gromov P, Lukanidin E, Kriajevska M, Mellon JK and...

Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta

Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these...
Authors: Smalley MJ, Signoret N, Robertson D, Tilley A, Hann A, Ewan K, Ding Y, Paterson H and Dale TC

cAMP-induced PKC activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors

Chemokines are key regulators of hematopoiesis and host defense. We report here that a functional expression of the chemokine receptor CXCR4 on human immature CD34(+) hematopoietic progenitors was increased as a result of sustained elevation in...
Authors: Goichberg P, Kalinkovich A, Borodovsky N, Tesio M, Petit I, Nagler A, Hardan I and Lapidot T

The PDZ binding motif of HTLV-1 tax promotes virus mediated T-cell proliferation in vitro and persistence in vivo

HTLV-1 cellular transformation and disease induction is dependent on expression of the viral Tax oncoprotein. PDZ is a modular protein interaction domain used in organizing signaling complexes in eukaryotic cells through recognition of a specific...
Authors: Xie L, Yamamoto B, Haoudi A, Semmes OJ and Green PL

Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has emerged as a novel anticancer agent. Previously, we showed that although most adult T-cell...
Authors: Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Yoshida T, Sakai T, Koyano T, Kam TS,...
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