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Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes

Total internal reflection fluorescence (TIRF) microscopy reveals highly mobile structures containing enhanced green fluorescent protein-tagged glucose transporter 4 (GLUT4) within a zone about 100 nm beneath the plasma membrane of 3T3-L1 adipocytes....

Authors: Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP

Resistance to TGF-1 correlated with aberrant expression of TGF- receptor II in human B-cell lymphoma cell lines

Resistance to transforming growth factor (TGF)-beta1-mediated growth suppression in tumor cells is often associated with the functional loss of TGF-beta receptors. Here we describe two B-cell lymphoma cell lines (DB and RL) that differ in their...

Authors: Chen G, Ghosh P, Osawa H, Sasaki CY, Rezanka L, Yang J, O'farrell TJ, Longo DL

Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function

Parafibromin is a tumor suppressor protein encoded by HRPT2, a gene recently implicated in the hereditary hyperparathyroidism-jaw tumor syndrome, parathyroid cancer, and a subset of kindreds with familial isolated hyperparathyroidism. Human...

Authors: Lin L, Czapiga M, Nini L, Zhang JH, Simonds WF

Method - A nonviral gene transfer method for transfection multipotent adult progenitor cells (MAPC)

Method - A nonviral gene transfer method for transfection multipotent adult progenitor cells (MAPC) Lakshmipathy U, Hammer L, Verfaillie C Multipotent adult progenitor cells (MAPC) are stem cells isolated primarily from adult bone marrow that...

Authors: Lakshmipathy U, Hammer L, Verfaillie C

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Developmental Regulation of Duox1 Expression and Function in Human Fetal Lung Epithelial Cells

The purpose of this study was to determine the expression and cellular functions of the epithelial NADPH oxidase DUOX1 during alveolar type II cell development. When human fetal lung cells (gestational age 11-22 wk) were cultured to confluency on...

Authors: Fischer H, Gonzales LK, Kolla V, Schwarzer C, Miot F, Illek B, Ballard PL

A Role for Type 1 Corticotropin-Releasing Hormone Receptors in Mediating Local Changes in Chronically Inflamed Tissue

Peripheral corticotropin-releasing hormone (CRH) is an important regulator of localized inflammatory responses. The aim of this study is to define the pathological signaling pathways in which peripheral CRH receptor-mediated responses reside. We...

Authors: Ralph JA, Zocco D, Bresnihan B, Fitzgerald O, McEvoy AN, Murphy EP

Plasmodium yoelii yoelii 17XNL constitutively expressing GFP throughout the life cycle

Plasmodium yoelii is a rodent parasite commonly used as a model to study malaria infection. It is the preferred model parasite for liver-stage immunological studies and is also widely used to study hepatocyte, erythrocyte and mosquito infection. We...

Authors: Ono T, Tadakuma T, Rodriguez A

Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt's lymphoma cells

PURPOSE: Epstein-Barr virus (EBV) is associated with the development of several lymphoid and epithelial malignancies, including Burkitt's lymphoma. The EBV latent protein, EBV Nuclear Antigen 1 (EBNA1), is detectable in almost all types of...

Authors: Hong M, Murai Y, Kutsuna T, Takahashi H, Nomoto K, Cheng CM, Ishizawa S, Zhao QL, Ogawa R, Harmon...

Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen

Primary effusion lymphoma (PEL) is a rare subtype of non-Hodgkin's lymphoma, which is associated with infection by Kaposi's sarcoma herpesvirus (KSHV)/human herpesvirus-8. The c-Myc transcription factor plays an important role in cellular...

Authors: Bubman D, Guasparri I, Cesarman E

Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation

We previously showed that inositol hexakisphosphate kinase 2 (IHPK2) functions as a growth-suppressive and apoptosis-enhancing kinase during cell stress. Overexpression of IHPK2 sensitized ovarian carcinoma cell lines to the growth-suppressive and...

Authors: Morrison BH, Bauer JA, Lupica JA, Tang Z, Schmidt H, Didonato JA, Lindner DJ

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