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alpha4 beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the 4-cytoplasmic domain

The capacity of integrins to mediate adhesiveness is modulated by their cytoplasmic associations. In this study, we describe a novel mechanism by which alpha(4)-integrin adhesiveness is regulated by the cytoskeletal adaptor paxillin. A mutation of...

Authors: Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V,...

Efficient nonviral gene delivery into primary lymphocytes from rats and mice

Efficient nonviral gene delivery into primary lymphocytes from rats and mice. Goffinet C, Keppler OT. A rapid method for efficient gene delivery into primary rodent lymphocytes would greatly facilitate the study of signaling and metabolic...

Authors: Goffinet C and Keppler OT

SST Peer Reviewed

A role for the neuronal protein collapsin response mediator protein 2 in T lymphocyte polarization and migration

The semaphorin-signaling transducer collapsin response mediator protein 2 (CRMP2) has been identified in the nervous system where it mediates Sema3A-induced growth cone navigation. In the present study, we provide first evidence that CRMP2 is present...

Authors: Vincent P, Collette Y, Marignier R, Vuaillat C, Rogemond V, Davoust N, Malcus C, Cavagna S, Gessain...

IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells

IL-21 is a recently described cytokine, produced by activated Th cells, that shares significant homology with members of the IL-2 family of cytokines. IL-21 mediates its biological effects via the IL-21R in conjunction with the common receptor...

Authors: Burgess SJ, Marusina AI, Pathmanathan I, Borrego F and Coligan JE

Opioids Trigger 5beta1 Integrin-Mediated Monocyte Adhesion

Inflammatory reactions involve a network of chemical and molecular signals that initiate and maintain host response. In inflamed tissue, immune system cells generate opioid peptides that contribute to potent analgesia by acting on specific peripheral...

Authors: Pello OM, Duthey B, Garcia-Bernal D, Rodriguez-Frade JM, Stein JV, Teixido J, Martinez-A C and...

The BTB domain of the nuclear matrix protein NRP/B is required for neurite outgrowth

The neuronal nuclear matrix protein, NRP/B, contains a BTB domain and kelch repeats and is expressed in primary neurons but not in primary glial cells. To examine the function of NRP/B in neurons, we analyzed the structure/function of the NRP/B-BTB...

Authors: Kim TA, Jiang S, Seng S, Cha K, Avraham HK and Avraham S

Characterization of SIS3, a Novel Specific Inhibitor of Smad3, and Its Effect on Transforming Growth Factor-beta1-Induced Extracellular Matrix Expression

This is the first report that characterizes specific inhibitor of Smad3 (SIS3) as a potent and selective inhibitor of Smad3 function. In the reporter assay, the increased luciferase activity of p3TP-lux by the overexpression of constitutively active...

Authors: Jinnin M, Ihn H and Tamaki K

Matrix Contraction by Dermal Fibroblasts Requires Transforming Growth Factor-/Activin-Linked Kinase 5, Heparan Sulfate-Containing Proteoglycans, and MEK/ERK: Insights into Pathological Scarring in Chronic Fibrotic Disease

CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology, Schulich School of Dentistry, University of Western Ontario, Dental Sciences Building, London, ON, Canada N6A 5C1. Scarring is characterized by excessive synthesis and...

Authors: Chen Y, Shi-Wen X, van Beek J, Kennedy L, McLeod M, Renzoni EA, Bou-Gharios G, Wilcox-Adelman S,...

Phosphatidylinositol 3-kinase functions as a ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after costimulation of untransformed human T lymphocytes

The activity of cofilin, an actin-remodeling protein, is required for T lymphocyte activation with regard to formation of the immunological synapse, cytokine production, and proliferation. In unstimulated T PBL (PB-T), cofilin is present in its...

Authors: Wabnitz GH, Nebl G, Klemke M, Schroder AJ, and Samstag Y

Long-term engagement of CD6 and ALCAM is essential for T cell proliferation induced by dendritic cells

Interactions between T cells and antigen-presenting cells are the first step in the induction of an adaptive immune response. Here, we show that CD6 and its ligand ALCAM are actively recruited to the antigen-induced DC-T cell contact zone. Moreover,...

Authors: Zimmerman AW, Joosten B, Torensma R, Parnes JR, van Leeuwen FN and Figdor CG

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