Data Type


Category

+ Show All

Research Area

+ Show All

Platform


Topic

+ Show All
4670 results sorted by

Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function

CD4(+)CD25(+)Foxp3(+) regulatory T cells (CD25(+) Tregs) direct the maintenance of immunological self-tolerance by active suppression of autoaggressive T cell populations. However, the molecules mediating the anergic state and regulatory function of...
Authors: Kubach J, Lutter P, Bopp T, Stoll S, Becker C, Huter E, Richter C, Weingarten P, Warger T, Knop J,...
SST Peer Reviewed

HTLV-1 Tax Protein Down-regulates the Pre-TCR Gene Transcription in Human Immature Thymocytes

The human pre-T-cell receptor alpha (TCRalpha; pTalpha) gene encodes a polypeptide which associates with the TCRbeta chain and CD3 molecules to form the pre-TCR complex. The surface expression of the pre-TCR is pTalpha dependent, and signaling...
Authors: Wencker M, Sausse C, Derse D, Gazzolo L, Dodon MD

Antiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathway

Recent data imply an important role for brain cytochrome P450 (P450) in endocrine signaling. In epileptic patients, treatment with P450 inducers led to reproductive disorders; in mouse hippocampus, phenytoin treatment caused concomitant up-regulation...
Authors: Gehlhaus M, Schmitt N, Volk B, Meyer R

Caspase-8 prevents sustained activation of NF-B in monocytes undergoing macrophagic differentiation

Caspases have demonstrated several nonapoptotic functions including a role in the differentiation of specific cell types. Here, we show that caspase-8 is the upstream enzyme in the proteolytic caspase cascade whose activation is required for the...
Authors: Rebe C, Cathelin S, Launay S, Filomenko R, Prevotat L, L'ollivier C, Gyan E, Micheau O, Grant S,...

Honokiol Induces a Necrotic Cell Death through the Mitochondrial Permeability Transition Pore

Previous reports have shown that honokiol induces apoptosis in numerous cancer cell lines and showed preclinical efficacies against apoptosis-resistant B-cell chronic lymphocytic leukemia and multiple myeloma cells from relapse-refractory patients....
Authors: Li L, Han W, Gu Y, Qiu S, Lu Q, Jin J, Luo J, Hu X
SST Peer Reviewed

Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread

Varicella-zoster virus (VZV) causes chickenpox and shingles. While varicella is likely spread as cell-free virus to susceptible hosts, the virus is transmitted by cell-to-cell spread in the body and in vitro. Since VZV glycoprotein E (gE) is...
Authors: Li Q, Ali MA, Cohen JI

Quantitative analysis of membrane remodeling at the phagocytic cup

Nascent phagosomes, which are derived from the plasma membrane, acquire microbicidal properties through multiple fusion and fission events collectively known as maturation. Here we show that remodelling of the phagosomal membrane is apparent even...
Authors: Lee WL, Mason D, Schreiber AD, Grinstein S
SST Peer Reviewed

Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation

Fibroblasts migrate into and repopulate connective tissue wounds. At the wound edge, fibroblasts differentiate into myofibroblasts and promote wound closure. Regulated fibroblast to myofibroblast differentiation is critical for regenerative healing....
Authors: Bernstein AM, Twining SS, Warejcka DJ, Tall E, Masur SK

E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells

Epithelial-mesenchymal transition (EMT) events occur during embryonic development and are important for the metastatic spread of epithelial tumors. We show here that spontaneous differentiation of mouse ES cells is associated with an E- to N-cadherin...
Authors: Spencer HL, Eastham AM, Merry CL, Southgate TD, Perez-Campo F, Soncin F, Ritson S, Kemler R, Stern...

SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes

SATB1 (special AT-rich sequence binding protein 1) organizes cell type-specific nuclear architecture by anchoring specialized DNA sequences and recruiting chromatin remodeling factors to control gene transcription. We studied the role of SATB1 in...
Authors: Cai S, Lee CC, Kohwi-Shigematsu T
PAGE 4