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c-Rel-Dependent Priming of Naive T Cells by Inflammatory Cytokines

The intrinsic refractoriness of naive T cells for cytokine production is counteracted by cells of the innate immune system. Upon sensing danger via Toll-like receptors, these cells upregulate T cell costimulatory molecules and secrete cytokines that...
Authors: Banerjee D, Liou HC and Sen R

Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

BCR/ABL-kinase mutations frequently mediate clinical resistance to the selective tyrosine kinase inhibitor Imatinib mesylate (IM, Gleevec((R))). However, mechanisms that promote survival of BCR/ABL-positive cells before clinically overt IM resistance...
Authors: Burchert A, Wang Y, Cai D, von Bubnoff N, Paschka P, Muller-Brusselbach S, Ottmann OG, Duyster J,...

Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells

KBM5 cells, derived from a patient with blast crisis Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML), and imatinib-resistant KBM5 (KBM5-STI571) cells were found to express high levels of survivin. Inhibition of Bcr-Abl by...
Authors: Carter BZ, Mak D, Schober WD, Cabreira-Hansen M, Beran M, McQueen T, Chen W, and Andreeff M

BBC3 mediates fenretinide-induced cell death in neuroblastoma

Fenretinide (4-HPR) is a synthetic retinoid whose apoptosis-inducing effects have been demonstrated in many tumor types. The precise mechanism of its apoptotic action is not fully understood. To further study the mechanism by which 4-HPR exerts its...
Authors: Wei JS, Whiteford CC, Cenacchi N, Son CG and Khan J

Olig2 overexpression induces the in vitro differentiation of neural stem cells into mature oligodendrocytes

Differentiation induction of neural stem cells (NSCs) into oligodendrocytes during embryogenesis is the result of a complex interaction between local induction factors and intracellular transcription factors. At the early stage of differentiation, in...
Authors: Copray S, Balasubramaniyan V, Levenga J, de Bruijn J, Liem R and Boddeke E

Neuregulin-1 Type III Determines the Ensheathment Fate of Axons

The signals that determine whether axons are ensheathed or myelinated by Schwann cells have long been elusive. We now report that threshold levels of neuregulin-1 (NRG1) type III on axons determine their ensheathment fate. Ensheathed axons express...
Authors: Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA,...

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

Germline NF1, c-RET, SDH, and VHL mutations cause familial pheochromocytoma. Pheochromocytomas derive from sympathetic neuronal precursor cells. Many of these cells undergo c-Jun-dependent apoptosis during normal development as NGF becomes limiting....
Authors: Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG...

A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA transcripts. Although the spatial and temporal patterning of miRNA expression is tightly controlled, little is known about signals that induce their...
Authors: Vo N, Klein ME, Varlamova O, Keller DM, Yamamoto T, Goodman RH and Impey S
SST Peer Reviewed

Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder that affects some adult carriers of premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene. FXTAS is thought to be caused by a...
Authors: Arocena DG, Iwahashi CK, Won N, Beilina A, Ludwig AL, Tassone F, Schwartz PH and Hagerman PJ

Different approaches for assaying melanosome transfer

Many approaches have been tried to establish assays for melanosome transfer to keratinocytes. In this report, we describe and summarize various novel attempts to label melanosomes in search of a reliable, specific, reproducible and quantitative assay...
Authors: Berens W, Van Den Bossche K, Yoon TJ, Westbroek W, Valencia JC, Out CJ, Marie Naeyaert J, Hearing VJ...
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