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Silencing of reversion-inducing cysteine-rich protein with Kazal motifs stimulates hyperplastic phenotypes through activation of epidermal growth factor receptor and hypoxia-inducible factor-2a

Reversion-inducing cysteine-rich protein with Kazal motifs (RECK, a tumor suppressor) is down-regulated by the oncogenic signals and hypoxia, but the biological function of RECK in early tumorigenic hyperplastic phenotypes is largely unknown....
Authors: Lee YM1, Lee SH1, Lee KB2, Nguyen MP1, Lee MY3, Park GH3, Kwon MJ

1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells

Antiviral drugs for treating polyomavirus BK (BKV) replication in polyomavirus-associated nephropathy or hemorrhagic cystitis are of considerable clinical interest. Unlike cidofovir, the lipid conjugate 1-O-hexadecyloxypropyl cidofovir (CMX001) is...
Authors: Rinaldo CH1, Gosert R, Bernhoff E, Finstad S, Hirsch HH

Association of DSC3 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis

BACKGROUND: Desmocollin 3 (DSC3), a member of the cadherin gene superfamily, is associated with pathogenesis of some cancers, but its role in prostate cancer (PCa) remains largely unknown. METHODS: DSC3 gene expression level in available PCa...
Authors: Pan J1, Chen Y1, Mo C1, Wang D1, Chen J1, Mao X1, Guo S2, Zhuang J1, Qiu S1.

A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells.

In vitro assays involving primary cells are used routinely to evaluate organ-specific toxic effects, for instance, the use of primary hepatocytes to evaluate hepatotoxicity. A major drawback of an in vitro system is the lack of multiple organ...
Authors: Li AP1, Bode C, Sakai Y

ZFP91-A Newly Described Gene Potentially Involved in Prostate Pathology

In search for novel molecular targets in benign prostate hyperplasia (BPH), a PCR Array based screening of 84 genes was performed. Of those, expression of ZFP91 (ZFP91 zinc finger protein) was notably upregulated. Limited data concerning the function...
Authors: Paschke L1, Rucinski M, Ziolkowska A, Zemleduch T, Malendowicz W, Kwias Z, Malendowicz LK

miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells

Adult renal progenitor cells (ARPCs) were recently identified in the cortex of the renal parenchyma and it was demonstrated that they were positive for PAX2, CD133, CD24 and exhibited multipotent differentiation ability. Recent studies on stem cells...
Authors: Sallustio F1, Serino G, Costantino V, Curci C, Cox SN, De Palma G, Schena FP.

Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells

Many tumors are stiffer than their surrounding tissue. This increase in stiffness has been attributed, in part, to a Rho-dependent elevation of myosin II light chain phosphorylation. To characterize this mechanism further, we studied myosin light...
Authors: Yu HJ1, Serebryannyy LA, Fry M, Greene M, Chernaya O, Hu WY, Chew TL, Mahmud N, Kadkol SS, Glover S,...

Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells.

The nonclassic class I human leukocyte antigen E (HLA-E) molecule engages the inhibitory NKG2A receptor on several cytotoxic effectors, including natural killer (NK) cells. Its tissue distribution was claimed to be wider in normal than in neoplastic...
Authors: Lo Monaco E1, Tremante E, Cerboni C, Melucci E, Sibilio L, Zingoni A, Nicotra MR, Natali PG,...

Hepatocyte growth factor preferentially activates the anti-inflammatory arm of NF-?B signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation

Inflammation induces the NF-?B dependent protein A20 in human renal proximal tubular epithelial cells (RPTEC), which secondarily contains inflammation by shutting down NF-?B activation. We surmised that inducing A20 without engaging the...
Authors: da Silva CG1, Maccariello ER, Wilson SW, Putheti P, Daniel S, Damrauer SM, Peterson CR, Siracuse JJ,...

Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract

The increased proliferation of cancer cells is directly dependent on the increased activity of the endoplasmic reticulum (ER) machinery which is responsible for protein folding, assembly, and transport. In fact, it is so critical that perturbations...
Authors: Li G1, Petiwala SM1, Pierce DR1, Nonn L2, Johnson JJ3.
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