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Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine

Prominin-2 is a pentaspan membrane glycoprotein structurally related to the cholesterol-binding protein prominin-1, which is expressed in epithelial and non-epithelial cells. Although prominin-1 expression is widespread throughout the organism, the...
Authors: Florek M, Bauer N, Janich P, Wilsch-Braeuninger M, Fargeas CA, Marzesco AM, Ehninger G, Thiele C,...

Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors

We have previously shown preferential tumor-homing and therapeutic efficacy of adoptively transferred type 1 CTL (Tc1) when compared with type 2 CTL (Tc2) in mice bearing intracranial ovalbumin-transfected melanoma (M05). Further characterizing the...
Authors: Sasaki K, Zhu X, Vasquez C, Nishimura F, Dusak JE, Huang J, Fujita M, Wesa A, Potter DM, Walker PR,...
SST Peer Reviewed

A 3' enhancer controls snail expression in melanoma cells

A 3' enhancer controls snail expression in melanoma cells. Palmer MB, Majumder P, Green MR, Wade PA, Boss JM. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. The snail gene encodes...
Authors: Palmer MB, Majumder P, Green MR, Wade PA, Boss JM

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin-mediated human T cell adhesion

Regulated adhesion of T cells by the integrins LFA-1 and VLA-4 is essential for T cell trafficking. The small GTPase Rap1 is a critical activator of both integrins in murine lymphocytes and T cell lines. Here we examined the contribution of the Rap1...
Authors: Ghandour H, Cullere X, Luscinskas FW, Mayadas TN

Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling

Antiestrogens such as tamoxifen are widely used in the clinic to treat estrogen receptor-positive breast tumors. Resistance to tamoxifen can occur either de novo or develop over time in a large proportion of these tumors. Additionally, resistance is...
Authors: Schrecengost RS, Riggins RB, Thomas KS, Guerrero MS, Bouton AH

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons

Huntingtin is an antiapoptotic protein that becomes toxic when its polyglutamine stretch is expanded, resulting in Huntington's disease (HD). Protein context and posttranslational modifications regulate huntingtin toxicity. Identifying signaling...
Authors: Anne SL, Saudou F, Humbert S

Pyrin Levels in Human Monocytes and Monocyte-Derived Macrophages Regulate IL-1beta Processing and Release

Macrophages and their precursors, monocytes, are key cells involved in the innate immune response. Although both monocytes and macrophages produce caspase-1, the key enzyme responsible for pro-IL-1beta processing; macrophages are limited in their...
Authors: Seshadri S, Duncan MD, Hart JM, Gavrilin MA, Wewers MD

Apoptosis-inducing factor regulates death in peripheral T cells

Apoptosis-inducing factor (Aif) is a mitochondrial flavoprotein with multiple roles in apoptosis as well as in cellular respiration and redox regulation. The harlequin (Hq) mouse strain carries an aif locus modification causing reduced Aif...
Authors: Srivastava S, Banerjee H, Chaudhry A, Khare A, Sarin A, George A, Bal V, Durdik JM, Rath S

Neurabin-I is phosphorylated by cdk5: implications for neuronal morphogenesis and cortical migration

The correct morphology and migration of neurons, which is essential for the normal development of the nervous system, is enabled by the regulation of their cytoskeletal elements. We reveal that Neurabin-I, a neuronal-specific F-actin-binding protein,...
Authors: Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M

The Atg5 Atg12 conjugate associates with innate antiviral immune responses

Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be elucidated. We show here that the Atg5-Atg12 conjugate, a key regulator of the autophagic process, plays an important role in...
Authors: Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki...
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