Search Results

A Polymer-based Piezoelectric Transducer for Real-time Monitoring Contractile Behavior of Cardiomyocytes

In this paper, we present an intelligent piezoelectric transducer that can automatically monitor the contractile behavior of cardiomyocytes for the application of drug screening. By integrating a biomimetic substrate and a piezoelectric smart...

Authors: Hsu1 YH, Shen JW, Lin YH

SST Peer Reviewed

Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations.

Current treatments that use hematopoietic progenitor cell (HPC) transplantation in acute myeloid leukemia (AML) patients substantially reduce the risk of relapse, but are limited by the availability of immune compatible healthy HPCs. Although...

Authors: Salci KR, Lee JH, Laronde S, Dingwall S, Kushwah R, Fiebig-Comyn A, Leber B, Foley R, Dal Cin A,...

SST Peer Reviewed

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.

Prialt, a synthetic version of Cav2.2 antagonist ?-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain. However, due to the narrow therapeutic window and...

Authors: Patel R, Rutten K, Valdor M, Schiene K, Wigge S, Schunk S, Damann N, Christoph T, Dickenson AH3

SST Peer Reviewed

Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis.

Human bone marrow mesenchymal progenitor cells (MPCs) are multipotent cells that play an essential role in endogenous repair and the maintenance of the stem cell niche. We have recently shown that high levels of glucose, conditions mimicking...

Authors: Keats EC, Dominguez JM, Grant MB, Khan ZA

SST Peer Reviewed

Resistin-like molecule-ß is a human airway remodelling mediator.

Though implicated in vascular remodelling, a role for the resistin-like molecule (RELM)-ß in human airway remodelling remains unexplored. We hypothesised that RELM-ß expression is increased in the airways of asthmatics and regulates airways...

Authors: Fang C, Meng Q, Wu H, Eid G, Zhang G, Zhang X, Yang S, Huang K, Lee TH, Corrigan CJ, Ying S.

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.

PURPOSE: The SET oncoprotein, a potent inhibitor of the protein phosphatase 2A (PP2A), is overexpressed in leukemia. We evaluated the efficacy of SET antagonism in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) cell lines, a murine...

Authors: Agarwal A, MacKenzie RJ, Pippa R, Eide CA, Oddo J, Tyner JW, Sears R, Vitek MP, Odero MD,...

SST Peer Reviewed

Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing required.

Primary ciliary dyskinesia (PCD) results in chronic nasal symptoms and chest disease leading to bronchiectasis. We noted a number of patients referred for diagnostic testing whose initial results suggested PCD due to an inner dynein arm or radial...

Authors: C. O’Callaghan, A. Rutman, G.M. Williams and R.A. Hirst

Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.

Transient cell therapy is an emerging drug class that requires new approaches for pharmacological monitoring during use. Human mesenchymal stem cells (MSCs) are a clinically-tested transient cell therapeutic that naturally secrete anti-inflammatory...

Authors: Elman JS, Murray RC, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R4,...

SST Peer Reviewed

Effect of oxidative stress on respiratory epithelium from children with Down syndrome

Children with Down syndrome are at high risk for acute respiratory distress syndrome. In Down syndrome, both regulation of inflammation and apoptosis, important in acute respiratory distress syndrome pathophysiology, are abnormal. This has been...

Authors: Bruijn M, Lutter R, Eldering E, Bos AP, van Woensel JB.

Therapeutic potential of ixmyelocel-T, an expanded autologous multicellular therapy for treatment of ischemic cardiovascular diseases.

INTRODUCTION: Bone marrow derived cellular therapies are an emerging approach to promoting therapeutic angiogenesis in ischemic cardiovascular disease. However, the percentage of regenerative cells in bone marrow mononuclear cells (BMMNCs) is small,...

Authors: Ledford KJ, Murphy N, Zeigler F, Bartel RL, Tubo R

SST Peer Reviewed

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Platform

Topic

A Polymer-based Piezoelectric Transducer for Real-time Monitoring Contractile Behavior of Cardiomyocytes

Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations.

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.

Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis.

Resistin-like molecule-ß is a human airway remodelling mediator.

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.

Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing required.

Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.

Effect of oxidative stress on respiratory epithelium from children with Down syndrome

Therapeutic potential of ixmyelocel-T, an expanded autologous multicellular therapy for treatment of ischemic cardiovascular diseases.