Search Results

Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces.

Human mesenchymal stem cells (hMSCs) have shown great potential for therapeutic purposes. However, the low frequencies of hMSCs in the body and difficulties in expanding their numbers in vitro have limited their clinical use. In order to develop an...

Authors: Hartrianti P, Ling L, Goh LM, Ow KS, Samsonraj RM, Sow WT, Wang S, Nurcombe V, Cool SM, Ng KW

SST Peer Reviewed

Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.

The relationships between commitments of dendritic cells (DCs) and T cells in human hematopoietic stem cells are not well understood. In this study, we enumerate and characterize conventional DC and plasmacytoid DC precursors in association with T...

Authors: Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink...

SST Peer Reviewed

Highly Efficient SiRNA and Gene Transfer into Hepatocyte-Like HepaRG Cells and Primary Human Hepatocytes: New Means for Drug Metabolism and Toxicity Studies

The metabolically competent hepatocyte-like human HepaRG cells represent a suitable alternative in vitro cell model to human primary hepatocytes. Here, we describe the culture procedure required to expand progenitor HepaRG cells and to differentiate...

Authors: Véronique Laurent, Denise Glaise, Tobias Nübel, David Gilot, Anne Corlu, Pascal Loyer

SST Peer Reviewed

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity.

Cell surface proteins have a wide range of biological functions, and are often used as lineage-specific markers. Antibodies that recognize cell surface antigens are widely used as research tools, diagnostic markers, and even therapeutic agents. The...

Authors: Gedye CA, Hussain A, Paterson J, Smrke A, Saini H, Sirskyj D, Pereira K, Lobo N, Stewart J, Go C, Ho...

SST Peer Reviewed

25 years of African trypanosome research: From description to molecular dissection and new drug discovery

The Molecular Parasitology conference was first held at the Marine Biological laboratory, Woods Hole, USA 25 years ago. Since that first meeting, the conference has evolved and expanded but has remained the showcase for the latest research...

Authors: Matthews KR1.

SST Peer Reviewed

Human CD38hiCD138? plasma cells can be generated in vitro from CD40-activated switched-memory B lymphocytes.

B lymphocyte differentiation into long-lived plasma cells is the keystone event for the production of long-term protective antibodies. CD40-CD154 and CD27-CD70 interactions are involved in human B lymphocyte differentiation into CD38(hi)CD138(+)...

Authors: Maïga RI, Bonnaure G, Rochette JT, Néron S

SST Peer Reviewed

Antenatal glucocorticoid therapy accelerates ATP production with creatine kinase increase in the growth-enhanced fetal rat heart

BACKGROUND: Previous study has demonstrated the increase of several cardiac function-related proteins, including creatine kinase (CK) as an important enzyme in the process of ATP synthesis in the fetal heart of rats administered glucocorticoid...

Authors: Mizuno M, Takeba Y, Matsumoto N, Tsuzuki Y, Asoh K, Takagi M, Kobayashi S, Yamamoto H

SST Peer Reviewed

Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells.

In 2003, we started autologous bone marrow cell infusion (ABMi) therapy for treating liver cirrhosis. ABMi therapy uses 400 mL of autologous bone marrow obtained under general anesthesia and infused mononuclear cells from the peripheral vein. The...

Authors: Terai S, Takami T, Yamamoto N, Fujisawa K, Ishikawa T, Urata Y, Tanimoto H, Iwamoto T, Mizunaga Y,...

SST Peer Reviewed

Progerin expression disrupts critical adult stem cell functions involved in tissue repair.

Vascular disease is one of the leading causes of death worldwide. Vascular repair, essential for tissue maintenance, is critically reduced during vascular disease and aging. Efficient vascular repair requires functional adult stem cells unimpaired by...

Authors: Pacheco LM, Gomez LA, Dias J, Ziebarth NM, Howard GA, Schiller PC

SST Peer Reviewed

Distinct functional programming of human fetal and adult monocytes.

Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-? (IFN-?),...

Authors: Krow-Lucal ER, Kim CC, Burt TD, McCune JM

SST Peer Reviewed

Data Type

Category

Research Area

Platform

Topic

Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces.

Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.

Highly Efficient SiRNA and Gene Transfer into Hepatocyte-Like HepaRG Cells and Primary Human Hepatocytes: New Means for Drug Metabolism and Toxicity Studies

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity.

25 years of African trypanosome research: From description to molecular dissection and new drug discovery

Human CD38hiCD138? plasma cells can be generated in vitro from CD40-activated switched-memory B lymphocytes.

Antenatal glucocorticoid therapy accelerates ATP production with creatine kinase increase in the growth-enhanced fetal rat heart

Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells.

Progerin expression disrupts critical adult stem cell functions involved in tissue repair.

Distinct functional programming of human fetal and adult monocytes.