Search Results

Endodontic antimicrobial photodynamic therapy: safety assessment in mammalian cell cultures

OBJECTIVES: The purpose of this study was to assess the in vitro synergistic effect of methylene blue (MB) and red light on human gingival fibroblasts and osteoblasts with parameters similar to those that may be applied in a clinical setting for...

Authors: Xu Y1, Young MJ, Battaglino RA, Morse LR, Fontana CR, Pagonis TC, Kent R, Soukos NS

Phosphatase inhibitors with anti-angiogenic effect in vitro.

Levamisole has previously been identified as an inhibitor of angiogenesis in vitro and in vivo, but the mechanism behind the anti-angiogenic behavior has not yet been established. However, one known effect of levamisole is the inhibition of alkaline...

Authors: Sylvest L1, Bendiksen CD, Houen G.

The kinase Mirk is a potential therapeutic target in osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor affecting children and adolescents. The majority of patients are treated by surgery and chemotherapy but have limited alternative therapeutic options. Kinases play an important role in the...

Authors: Yang C1, Ji D, Weinstein EJ, Choy E, Hornicek FJ, Wood KB, Liu X, Mankin H, Duan Z.

Matched pairs of human prostate stromal cells display differential tropic effects on LNCaP prostate cancer cells.

Prostate stromal cells may play binary roles in the process of prostate cancer development. As the first to be encountered by infiltrating prostate cancer cells, prostate stromal cells form the first defense line against prostate cancer progression...

Authors: Sun X1, He H, Xie Z, Qian W, Zhau HE, Chung LW, Marshall FF, Wang R.

Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression.

We have previously shown that human prostate cancer cells are capable of acquiring malignant attributes through interaction with stromal cells in the tumor microenvironment, while the interacting stromal cells can also become affected with both...

Authors: Wang R1, Sun X, Wang CY, Hu P, Chu CY, Liu S, Zhau HE, Chung LW.

Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.

Unique insights for the reprograming of cell lineages have come from embryonic development in the ascidian Ciona, which is dependent upon the transcription factors Ci-ets1/2 and Ci-mesp to generate cardiac progenitors. We tested the idea that...

Authors: Islas JF1, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer...

On the formation of lipid droplets in human adipocytes: the organization of the perilipin-vimentin cortex.

We report on the heterogeneity and diversity of lipid droplets (LDs) in early stages of adipogenesis by elucidating the cell and molecular biology of amphiphilic and cytoskeletal proteins regulating and stabilizing the generation of LDs in human...

Authors: Heid H1, Rickelt S1, Zimbelmann R1, Winter S1, Schumacher H1, Dörflinger Y1, Kuhn C2, Franke WW3.

SST Peer Reviewed

Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells

Autologous retinal pigment epithelium (RPE) grafts derived from induced pluripotent stem cells (iPSCs) may be used to cure blinding diseases in which RPE dysfunction results in photoreceptor degeneration. Four-, two-, and one-factor-derived iPSCs...

Authors: Ukrohne TU1, Westenskow PD, Kurihara T, Friedlander DF, Lehmann M, Dorsey AL, Li W, Zhu S, Schultz...

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.

Parafibromin is a tumor suppressor protein encoded by HRPT2, a gene recently implicated in the hereditary hyperparathyroidism-jaw tumor syndrome, parathyroid cancer, and a subset of kindreds with familial isolated hyperparathyroidism. Human...

Authors: Lin L1, Zhang JH, Panicker LM, Simonds WF.

Leflunomide inhibition of BK virus replication in renal tubular epithelial cells

The immunomodulatory drug leflunomide is frequently used for treating polyomavirus-associated nephropathy, yet its antiviral mechanism is unclear. We characterized the effects of the active leflunomide metabolite A771726 (LEF-A) on the polyomavirus...

Authors: Bernhoff E1, Tylden GD, Kjerpeseth LJ, Gutteberg TJ, Hirsch HH, Rinaldo CH

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