Search Results

IL-25 drives remodelling in allergic airways disease induced by house dust mite.

BACKGROUND: Overexpression of the transforming growth factor ß family signalling molecule smad2 in the airway epithelium provokes enhanced allergen-induced airway remodelling in mice, concomitant with elevated levels of interleukin (IL)-25....

Authors: Gregory LG1, Jones CP, Walker SA, Sawant D, Gowers KH, Campbell GA, McKenzie AN, Lloyd CM.

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.

To discover more potent p97 inhibitors, we carried out a structure-activity relationship study of the quinazoline scaffold previously identified from our HTS campaigns. Two improved inhibitors, ML240 and ML241, inhibit p97 ATPase with IC(50) values...

Authors: Chou TF1, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ.

Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.

Breast cancers with a basal-like gene signature are primarily triple-negative, frequently metastatic, and carry a poor prognosis. Basal-like breast cancers are enriched for markers of breast cancer stem cells as well as markers of...

Authors: D\\\\\\\\\\\\\\\'Amato NC1, Ostrander JH, Bowie ML, Sistrunk C, Borowsky A, Cardiff RD, Bell K,...

2D difference gel electrophoresis analysis of different time points during the course of neoplastic transformation of human mammary epithelial cells.

Cell culture models of oncogenesis that use cellular reprogramming to generate a neoplastic cell from a normal cell provide one of the few opportunities to study the early stages of breast cancer development. Human mammary epithelial cells (HMECs)...

Authors: DeAngelis JT1, Li Y, Mitchell N, Wilson L, Kim H, Tollefsbol TO.

Effect of ?-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.

BACKGROUND: It is becoming increasingly recognised that opioids are responsible for tumour growth. However, the effects of opioids on tumour growth have been controversial. METHODS: The effects of ?-opioid receptor (KOR) agonist on the growth of...

Authors: Kuzumaki N1, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada...

Study of neuron survival on polypyrrole-embedded single-walled carbon nanotube substrates for long term growth conditions.

Cultures of primary embryonic rat brain hippocampus neurons with supporting glia cells were carried out on different substrates containing polypyrrole (PPy) and/or single-walled carbon nanotubes (SWCNTs). Neuron adhesion, neurites and dendrites...

Authors: Hernández-Ferrer J1, Pérez-Bruzón RN, Azanza MJ, González M, Del Moral R, Ansón-Casaos A, de la...

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Glucocorticoid enhances hypoxia- and/or transforming growth factor-ß-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells

BACKGROUND: Glucocorticoid (GC) treatment reportedly exaggerates renal fibrosis in progressive kidney diseases during which hypoxia occurs as an unavoidable consequence in renal tubular cells. Two major fibrotic factors, hypoxia and transforming...

Authors: Kimura H1, Li X, Torii K, Okada T, Kamiyama K, Mikami D, Kasuno K, Takahashi N, Yoshida H

Regulatory Effects of microRNA-92 (miR-92) on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear Cell Renal Cell Carcinoma

Background & Aims: In order to understand the role of miRNAs in renal tumorigenesis, we undertook a stepwise approach that included a comprehensive differential miRNA expression analysis for the most common histological subtypes of human renal...

Authors: Valera VA1, Walter BA, Linehan WM, Merino MJ.

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

Energy deregulation and abnormalities of tumor cell metabolism are critical issues in understanding cancer. Hereditary leiomyomatosis renal cell carcinoma (HLRCC) is an aggressive form of RCC characterized by germline mutation of the Krebs cycle...

Authors: Yang Y1, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G,...

The directed differentiation of human iPS cells into kidney podocytes

The loss of glomerular podocytes is a key event in the progression of chronic kidney disease resulting in proteinuria and declining function. Podocytes are slow cycling cells that are considered terminally differentiated. Here we provide the first...

Authors: Song B1, Smink AM, Jones CV, Callaghan JM, Firth SD, Bernard CA, Laslett AL, Kerr PG, Ricardo SD

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