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4707 results sorted by

JNK-dependent release of mitochondrial protein, SMAC during apoptosis in multiple myeloma (MM) cells

Smac, second mitochondria-derived activator of caspases, promotes apoptosis via activation of caspases. Previous studies have shown that c-Jun NH(2)-terminal kinase (JNK) is involved in regulating another mitochondrial protein, cytochrome c during...
Authors: Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Midsiades N, Munshi N, Kharbanda S and Anderson...

Pericyte-specific expression of RGs5: implications for PDGF and EDG receptor signaling during vascular maturation

RGS proteins finely tune heterotrimeric G-protein signaling. Implying the need for such fine-tuning in the developing vascular system, in situ hybridization revealed a striking and extensive expression pattern of Rgs5 in the arterial walls of...
Authors: Cho H, Kozasa T, Bondjers C, Betsholtz C and Kehrl JH

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Apoptosis is a form of programmed cell death that is controlled by aspartate-specific cysteine proteases called caspases. In the immune system, apoptosis counters the proliferation of lymphocytes to achieve a homeostatic balance, which allows potent...
Authors: Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG,...
SST Peer Reviewed

RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy

Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such...
Authors: Coughlin CM, Vance BA, Grupp SA and Vonderheide RH
SST Peer Reviewed

Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism

The 'classical' NF-kappaB activation pathway proceeds via IkappaB kinase (IKK)-beta/gamma-mediated phosphorylation, induced ubiquitination and the degradation of small IkappaBs. An alternative, NF-kappaB-inducing kinase and IKK-alpha-dependent...
Authors: Mordmüller B, Krappmann D, Esen M, Wegener E and Scheidereit C

Marlin-1 a novel RNA binding protein associates with GABA(subB) receptors

GABA(subB) receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the CNS. While heterodimerization between GABA(subB) receptor GABA(subB)R1 and GABA(subB)R2 subunits is essential for functional expression,...
Authors: Couve A, Restituito S, Brandon JM, Charles KJ, Bawagan H, Freeman KB, Pangalos MN, Calver AR and...

Human parvovirus B19 nonstructural protein (NS1) induces cell cycle arrest at G1 phase

Human parvovirus B19 infects predominantly erythroid precursor cells, leading to inhibition of erythropoiesis. This erythroid cell damage is mediated by the viral nonstructural protein 1 (NS1) through an apoptotic mechanism. We previously...
Authors: Morita E, Nakashima A, Asao H, Sato H and Sugamura K

CD154 transcriptional regulation in primary human CD4 T cells

CD154 (CD40-ligand) has a wide variety of pleiotropic effects throughout the immune system and is critical to both cellular and humoral immunity. Cell surface and soluble CD154 are primarily expressed by activated CD4 T cells. Expression of CD154 is...
Authors: Cron RQ

YY1 transcription factor down-regulates expression of CCR5, a major co-receptor for HIV-1

Expression of CCR5, a major coreceptor for human immunodeficiency virus type 1 (HIV-1), is regulated by a number of transcription factors. Here we report that the YY1 transcription factor down-regulates CCR5 promoter activity and that overexpression...
Authors: Moriuchi M and Moriuchi H

Rapid and efficient electroporation-based gene transfer into primary dissociated neurons

Non-viral gene transfer into neurons has proved to be a formidable task. Here, we describe an electroporation-based method that allows efficient and reliable DNA transfer into dissociated neural cells before they are plated and cultured. In...
Authors: Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M and Dityatev A
SST Peer Reviewed
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