Data Type


Category

+ Show All

Research Area

+ Show All

Platform


Topic

+ Show All
4894 results sorted by

Large genomic fragment deletions and insertions in mouse using CRISPR/Cas9.

ZFN, TALENs and CRISPR/Cas9 system have been used to generate point mutations and large fragment deletions and insertions in genomic modifications. CRISPR/Cas9 system is the most flexible and fast developing technology that has been extensively used...
Authors: Zhang L, Jia R, Palange NJ, Satheka AC, Togo J, An Y2, Humphrey M, Ban L, Ji Y, Jin H2, Feng X,...
SST Peer Reviewed

BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation.

Adult renal progenitor cells (ARPCs) isolated from the human kidney may contribute to repair featuring acute kidney injury (AKI). Bone morphogenetic proteins (BMPs) regulate differentiation, modeling, and regeneration processes in several tissues....
Authors: Simone S, Cosola C, Loverre A, Cariello M, Sallustio F, Rascio F, Gesualdo L, Schena FP, Grandaliano...

Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells

Nerve growth factor (NGF) is overexpressed in patients with inflammatory lung diseases, including virus infections. Airway surface liquid (ASL), which is regulated by epithelial cell ion transport, is essential for normal lung function. No...
Authors: Shimko MJ, Zaccone EJ, Thompson JA, Schwegler-Berry D, Kashon ML, Fedan JS

Nuclease-mediated double-strand break (DSB) enhancement of small fragment homologous recombination (SFHR) gene modification in human-induced pluripotent stem cells (hiPSCs).

Recent developments in methods to specifically modify genomic DNA using sequence-specific endonucleases and donor DNA have opened the door to a new therapeutic paradigm for cell and gene therapy of inherited diseases. Sequence-specific endonucleases,...
Authors: Sargent RG, Suzuki S, Gruenert DC.
SST Peer Reviewed

Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice.

Nogo-B, also known as reticulon 4B, promotes liver fibrosis and cirrhosis by facilitating the transforming growth factor ß (TGF-ß) signaling pathway in activated hepatic stellate cells. The aim of this study was to determine the role of Nogo-B in...
Authors: Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y.

Tight junction disruption by cadmium in an in vitro human airway tissue model

BACKGROUND: The cadmium (Cd) present in air pollutants and cigarette smoke has the potential of causing multiple adverse health outcomes involving damage to pulmonary and cardiovascular tissue. Injury to pulmonary epithelium may include alterations...
Authors: Cao X, Lin H, Muskhelishvili L, Latendresse J, Richter P, Heflich RH

Human induced pluripotent stem cells are capable of B-cell lymphopoiesis

Induced pluripotent stem (iPS) cells offer a unique potential for understanding the molecular basis of disease and development. Here we have generated several human iPS cell lines, and we describe their pluripotent phenotype and ability to...
Authors: Lee Carpenter, Ram Malladi, Cheng-Tao Yang, Anna French, Katherine J. Pilkington, Richard W....
SST Peer Reviewed

Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

The establishment of self-renewing hepatoblast-like cells (HBCs) from human pluripotent stem cells (PSCs) would realize a stable supply of hepatocyte-like cells for medical applications. However, the functional characterization of human PSC-derived...
Authors: Takayama K1, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K,...

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M

Glucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not...
Authors: Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD

Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease

Clinical studies using bone marrow-derived proangiogenic cells (PACs) have demonstrated modest improvements of function and/or perfusion of ischemic myocardium or skeletal muscle. Because the identities of these PACs and their functional ability to...
Authors: Wara AK, Croce K, Foo S, Sun X, Icli B, Tesmenitsky Y, Esen F, Rosenzweig A, Feinberg MW.
SST Peer Reviewed
PAGE 16