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Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells

Type 3 von Willebrand disease (VWD) is a severe hemorrhagic defect in humans. We now identify the homozygous mutation in the Chapel Hill strain of canine type 3 VWD that results in premature termination of von Willebrand factor (VWF) protein...
Authors: Haberichter SL, Merricks EP, Fahs SA, Christopherson PA, Nichols TC and Montgomery RR

The interferon regulatory factor, IRF5, is a central mediator of TLR7 signaling

Interferon regulatory factors (IRFs) are critical components of virus-induced immune activation and type I interferon regulation. IRF-3 and IRF-7 are activated in response to a variety of viruses or following engagement of Toll-Like Receptor (TLR) 3...
Authors: Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA and Golenbock DT

Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase C delta/c-Src pathways in glioblastoma cells

Both epidermal growth factor receptor (EGFR) and protein kinase C (PKC) play important roles in glioblastoma invasive growth, however, the interaction between EGFR and PKC is not well characterized in glioblastomas. Treatment with EGF stimulated...
Authors: Amos S, Martin PM, Polar GA, Parsons SJ and Hussaini IM

p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells

Although PS-341 (bortezomib) is a promising agent to improve multiple myeloma (MM) patient outcome, 65% of patients with relapsed and refractory disease do not respond. We have previously shown that heat shock protein (Hsp)27 is upregulated after...
Authors: Hideshima T, Podar K, Chauhan D, Ishitsuka K, Mitsiades C, Tai YT, Hamasaki M, Raje N, Hideshima H,...

The steroid receptor co-activator-1 (SRC-1) potentiates TGF-beta/Smad signaling: role of p300/CBP

The three related 160-kDa proteins, SRC-1, TIF-2 and RAC-3, were initially identified as factors interacting with nuclear receptors. They have also been reported to potentiate the activity of other transcription factors such as AP-1 or NF-kappaB. The...
Authors: Dennler S, Pendaries V, Tacheau C, Costas MA, Mauviel A and Verrecchia F

Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum

The endoplasmic reticulum (ER) contains a number of thiol-disulfide oxidoreductases of the protein disulfide isomerase (PDI)-family that catalyze the formation of disulfide bonds in newly synthesized proteins. Here we describe the identification and...
Authors: Haugstetter J, Blicher T and Ellgaard L

Role of Rho/ROCK and p38 MAP kinase pathways in TGF-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo

TGF-beta is a multifunctional cytokine known to exert its biological effects through a variety of signaling pathways of which Smad signaling is considered to be the main mediator. At present, the Smad-independent pathways, their interactions with...
Authors: Kamaraju AK and Roberts AB

Defining the CREB Regulon; A Genome-Wide Analysis of Transcription Factor Regulatory Regions

The CREB transcription factor regulates differentiation, survival, and synaptic plasticity. The complement of CREB targets responsible for these responses has not been identified, however. We developed a novel approach to identify CREB targets,...
Authors: Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G and...

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

In animals, cells are dependent on extracellular signals to prevent apoptosis. However, using growth factor-dependent cells from Bax/Bak-deficient mice, we demonstrate that apoptosis is not essential to limit cell autonomous survival. Following...
Authors: Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T and Thompson CB

Pro-angiogenic signaling by endothelial presence of CEA-related cell adhesion molecule-1 (CEACAM1)

Here, we demonstrate the expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in angiogenic sprouts but not in large mother blood vessels within tumor tissue. Correspondingly, only human microvascular endothelial cells...
Authors: Kilic N, Oliviera-Ferrer L, Loges S, Chalajour F, Weil J, Fernando M, Ergun S
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