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4785 results sorted by

Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression

Removal of apoptotic cells by phagocytes is considered a pivotal immune regulatory process. Although considerable knowledge has been obtained on the postphagocytic macrophage phenotype, there is little information on molecular mechanisms, which...
Authors: Johann AM, Weigert A, Eberhardt W, Kuhn AM, Barra V, von Knethen A, Pfeilschifter JM, Brüne B

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

Diabetic patients continue to develop inflammation and vascular complications even after achieving glycemic control. This poorly understood "metabolic memory" phenomenon poses major challenges in treating diabetes. Recent studies demonstrate a link...
Authors: Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R

Active beta-catenin signaling is an inhibitory pathway of HIV replication in peripheral blood mononuclear cells

The Wnt/beta-catenin pathway is involved in cell functions governing development and disease. In modeling post-entry restriction to HIV replication in astrocytes, we reported that part of this natural resistance to productive replication of HIV in...
Authors: Kumar A, Zloza A, Moon RT, Watts J, Tenorio AR, Al-Harthi L

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor, A443654, in T-Acute Lymphoblastic Leukemia

Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the novel AKT inhibitor, A443654, leads to rapid cell death of T-ALL lines and patient samples. Treatment of CEM, Jurkat, and...
Authors: Fala F, Blalock WL, Tazzari P, Cappellini A, Chiarini F, Martinelli G, Tafuri A, McCubrey JA, Cocco...

Pluripotency of a Single Spermatogonial Stem Cell in Mice

Although pluripotent stem cells were recently discovered in postnatal testis, attempts to analyze their developmental potential have led to conflicting claims that spermatogonial stem cells are pluripotent or that they lose spermatogenic potential...
Authors: Kanatsu-Shinohara M, Lee J, Inoue K, Ogonuki N, Miki H, Toyokuni S, Ikawa M, Nakamura T, Ogura A,...
SST Peer Reviewed

ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle uncoupling protein 3

Hypoxia induces oxidative damage in skeletal muscle. Uncoupling protein 3 (UCP3) is the skeletal muscle enriched uncoupling protein and has previously been shown to confer resistance against oxidative stress. We show that hypoxia robustly upregulates...
Authors: Lu Z, Sack MN

MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis

Phagocytosis and subsequent degradation of pathogens by macrophages play a pivotal role in host innate immune responses to microbial infection. Recent studies have shown that Toll-like receptors (TLRs) play an important role in promoting the...
Authors: Kong L, Ge BX

STAP-2 negatively regulates both canonical and non-canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1

Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin homology (PH) and Src homology 2 (SH2)-like domains, as well as a proline-rich domain in its C-terminal region. In previous studies, we...
Authors: Ikeda O, Sekine Y, Yasui T, Oritani K, Sugiyma K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T

Binding of the P2Y2 Nucleotide Receptor to Filamin A Regulates Migration of Vascular Smooth Muscle Cells

The functional expression of the G protein-coupled P2Y2 nucleotide receptor (P2Y2R) has been associated with proliferation and migration of vascular smooth muscle cells (SMCs), 2 processes involved in atherosclerosis and restenosis. Activation of the...
Authors: Yu N, Erb L, Shivaji R, Weisman GA, Seye CI

Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation

Y-27632, an inhibitor of the Rho-associated kinase ROCK, is a therapeutic lead for Huntington disease (HD). The downstream targets that mediate its inhibitory effects on huntingtin (Htt) aggregation and toxicity are unknown. We have identified...
Authors: Shao J, Welch WJ, Diprospero NA, Diamond MI