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4785 results sorted by

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) mediated by Th17 and Th1 cells. DNA microarray analysis previously showed that NR4A2, an orphan nuclear receptor, is strongly up-regulated in the peripheral blood T...
Authors: Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T

STAT5b, c-Src, and EGFR Signaling Play Integral Roles in Estrogen-Stimulated Proliferation of ER-Positive Breast Cancer Cells

17beta-estradiol (E2) acts through the estrogen receptor alpha (ERalpha) to stimulate breast cancer proliferation. Here, we investigated the functional relationship between ERalpha and STAT5b activity in ER+ MCF-7 and T47D human breast cancer cells...
Authors: Fox EM, Bernaciak TM, Wen J, Weaver AM, Shupnik MA, Silva CM

A function retained by the common mutant CLN3 protein is responsible for the late onset of juvenile neuronal ceroid lipofuscinosis

The neuronal ceroid lipofuscinoses (NCLs) are common neurodegenerative disorders of childhood and are classified as lysosomal storage diseases since affected cells exhibit lysosomes containing ceroid and lipofuscin-like material. CLN3 is the most...
Authors: Kitzmuller C, Haines RL, Codlin S, Cutler DF, Mole SE

Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts

In immature dendritic cells (DCs), CD1a is almost exclusively expressed at the cell surface and its membrane organization is poorly understood. In this study, we report that MHC class II, invariant chain (Ii), and CD9 molecules are...
Authors: Sloma I, Zilber MT, Vasselon T, Setterblad N, Cavallari M, Mori L, De Libero G, Charron D, Mooney N,...

IL-3 induced c-Fos activation is modulated by Gab2-calcineurin interaction

IL-3 regulates cell growth by affecting various processes such as cell death, survival and proliferation. Cues from the external environment are sensed by surface receptors, and complex signaling mechanisms within the cells lead to specific...
Authors: Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ

Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization

Human rhinovirus (HRV) causes the common cold. The most common acute infection in humans, HRV is a leading cause of exacerbations of asthma and chronic obstruction pulmonary disease because of its ability to exacerbate airway inflammation by altering...
Authors: Lau C, Wang X, Song L, North M, Wiehler S, Proud D, Chow CW

Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells

Killer Ig-like receptor (KIR) expression is mostly restricted to NK cells controlling their activation. With increasing age, KIRs are expressed on T cells and contribute to age-related diseases. We examined epigenetic mechanisms that determine the...
Authors: Li G, Weyand CM, Goronzy JJ

Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells

PURPOSE: The goal of this study was to characterize interactions between the proteasome inhibitor bortezomib and the histone deacetylase (HDAC) inhibitors (HDACI) romidepsin or belinostat in chronic lymphocytic leukemia (CLL) cells. EXPERIMENTAL...
Authors: Dai Y, Chen S, Kramer LB, Funk VL, Dent P, Grant S

An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3

Dysregulation of protein synthesis has been implicated in oncogenesis through a mechanism whereby "weak" mRNAs encoding proteins involved in cell proliferation are strongly translated when the protein synthesis apparatus is activated. Previous work...
Authors: Zhang L, Smit-McBride Z, Pan X, Rheinhardt J, Hershey JW

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

MicroRNAs (miRNAs) are noncoding RNAs that base pair imperfectly to homologous regions in target mRNAs and negatively influence the synthesis of the corresponding proteins. Repression is mediated by a number of mechanisms, one of which is the direct...
Authors: Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M,...