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Development of a biosafety enhanced and immunogenic Salmonella enteritidis ghost using an antibiotic resistance gene free plasmid carrying a bacteriophage lysis system.

In the development of genetically inactivated bacterial vaccines, plasmid retention often requires the antibiotic resistance gene markers, the presence of which can cause the potential biosafety hazards such as the horizontal spread of resistance...
Authors: Jawale CV1, Lee JH

Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.

Breast cancer is one of the most common cancers among women in the United States. Although there are effective drugs for treating advanced stages of breast cancers, women eventually develop resistance. One of the approaches to control breast cancer...
Authors: Ray RB1, Raychoudhuri A, Steele R, Nerurkar P.

Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells.

Most cell membrane proteins are known or predicted to be glycosylated in eukaryotic organisms, where surface glycans are essential in many biological processes including cell development and differentiation. Nonetheless, the glycosylation on cell...
Authors: An HJ1, Gip P, Kim J, Wu S, Park KW, McVaugh CT, Schaffer DV, Bertozzi CR, Lebrilla CB.

TNF stimulates nuclear export and secretion of IL-15 by acting on CRM1 and ARF6

Interleukin (IL)-15 is a ubiquitously expressed cytokine that in the basal state is mainly localized intracellularly, including the nucleus. Unexpectedly, tumor necrosis factor-a (TNF) time-dependently induced nuclear export of IL-15Ra and IL15. This...
Authors: Ouyang S1, Hsuchou H, Kastin AJ, Pan W

Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia

Because natural killer (NK) cells kill tumor cells and combat infections, there is growing interest in adoptively transferring NK cells to hematopoietic stem cell recipients. Unfortunately, in humans, the activity of NK cells against Aspergillus...
Authors: Schmidt S1, Tramsen L, Hanisch M, Latgé JP, Huenecke S, Koehl U, Lehrnbecher T.

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective dyrk/clk inhibitors.

The Dyrk family of protein kinases is implicated in the pathogenesis of several diseases, including cancer and neurodegeneration. Pharmacological inhibitors were mainly described for Dyrk1A so far, but in fewer cases for Dyrk1B, Dyrk2 or other...
Authors: Schmitt C1, Kail D2, Mariano M1, Empting M3, Weber N1, Paul T1, Hartmann RW4, Engel M1.

Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer.

Long interspersed nuclear element 1 (L1) belongs to a family of retrotransposons. Expression of the normally repressed L1 retrotransposons has been shown to induce genome instability by creating DNA double-stranded breaks and chromosomal...
Authors: Chen L1, Dahlstrom JE, Chandra A, Board P, Rangasamy D.

Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.

Altered T cell function in systemic lupus erythematosus (SLE) is determined by various molecular and cellular abnormalities, including increased IL-17 production. Recent evidence suggests a crucial role for signaling lymphocyte activation molecules...
Authors: Chatterjee M1, Rauen T, Kis-Toth K, Kyttaris VC, Hedrich CM, Terhorst C, Tsokos GC.

TNFa and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells

BACKGROUND: Inflammation is a well-known etiological factor for colorectal cancer, but mechanisms underlying the linkage between inflammation and cancer are incompletely understood. We hypothesized that two pro-inflammatory cytokines, TNFa and IL-17,...
Authors: Straus DS

Notch signaling regulates mouse and human Th17 differentiation

Th17 cells are known to play a critical role in adaptive immune responses to several important extracellular pathogens. Additionally, Th17 cells are implicated in the pathogenesis of several autoimmune and inflammatory disorders as well as in cancer....
Authors: Keerthivasan S1, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I,...