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A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Cell signalling and mechanics influence vascular pathophysiology and there is an increasing demand for in vitro model systems that enable examination of signalling between vascular cells under hemodynamic conditions. Current 3D vessel wall constructs...

Authors: van Engeland NCA1, Pollet AMAO, den Toonder JMJ, Bouten CVC, Stassen OMJA, Sahlgren CM

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.

Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics and toxicity are essential constituents of preclinical safety assessment pipelines for new medicines. Here, we compared three emerging cell...

Authors: Bell CC1, Lauschke VM2, Vorrink SU1, Palmgren H1, Duffin R1, Andersson TB1, Ingelman-Sundberg M1

The HIV co-receptor CCR5 regulates osteoclast function.

C-C chemokine receptor 5 (CCR5) is a co-receptor of HIV. Epidemiological findings suggest that the functional loss of CCR5 is correlated with a lower incidence of bone-destructive diseases as well as of HIV transmission. However, it is not clear...

Authors: Lee JW1, Hoshino A2, Inoue K3, Saitou T4,5, Uehara S6, Kobayashi Y7, Ueha S8, Matsushima K8,...

An advanced tri-culture model to evaluate the dynamic interplay among osteoblasts, osteoclasts, and endothelial cells.

The dynamic metabolism and the numerous roles of bone tissue necessitate a suitable in vitro model to represent them. In order to investigate the interaction among the several cell types composing bone microenvironment, we studied a tri-culture model...

Authors: Pagani S1, Torricelli P1, Veronesi F1, Salamanna F2, Cepollaro S1,3, Fini M1

Induction of expression of aryl hydrocarbon receptor-dependent genes in human HepaRG cell line modified by shRNA and treated with ß-naphthoflavone

The aryl hydrocarbon receptor (AhR) mediates a variety of biological responses to ubiquitous environmental pollutants. In this study, the effects of administration of ß-naphthoflavone (BNF), a potent AhR ligand, on the expression of AhR-dependent...

Authors: Brauze D1, Zawierucha P2,3, Kiwerska K4, Bednarek K4, Oleszak M4, Rydzanicz M4,5, Jarmuz-Szymczak...

Strontium-Substituted Hydroxyapatite-Gelatin Biomimetic Scaffolds Modulate Bone Cell Response.

Strontium has a beneficial role on bone remodeling and is proposed for the treatment of pathologies associated to excessive bone resorption, such as osteoporosis. Herein, the possibility to utilize a biomimetic scaffold as strontium delivery system...

Authors: Panzavolta S1, Torricelli P2, Casolari S1, Parrilli A2, Fini M2, Bigi A1

Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells

Inorganic arsenic is a human carcinogen associated with several types of cancers, including liver cancer. Inorganic arsenic has been postulated to target stem cells, causing their oncogenic transformation. This is proposed to be one of the key events...

Authors: Dreval K1, Tryndyak V1, Kindrat I1,2, Twaddle NC1, Orisakwe OE1,3, Mudalige TK4, Beland FA1, Doerge...

Dendritic cell MST1 inhibits Th17 differentiation.

Although the differentiation of CD4+T cells is widely studied, the mechanisms of antigen-presenting cell-dependent T-cell modulation are unclear. Here, we investigate the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and...

Authors: Li C1,2, Bi Y3, Li Y1,2, Yang H2, Yu Q1, Wang J1,2, Wang Y1,2, Su H1,2, Jia A1, Hu Y1, Han L1, Zhang...

Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126.

Chemical pollutant exposure is a risk factor contributing to the growing epidemic of non-alcoholic fatty liver disease (NAFLD) affecting human populations that consume a western diet. Although it is recognized that intoxication by chemical pollutants...

Authors: Mesnage R1, Biserni M1, Balu S2, Frainay C3, Poupin N3, Jourdan F3, Wozniak E4, Xenakis T4, Mein...

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.

Despite the development of combined modality treatments against liposarcoma in recent years, a significant proportion of patients respond only modestly to such approaches, possibly contributing to local or distant recurrence. Early detection of...

Authors: Casadei L1,2, Calore F3, Creighton CJ4, Guescini M5, Batte K1,2, Iwenofu OH6, Zewdu A1,2, Braggio...

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