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Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

Interleukin 1 (IL-1) has been reported to stimulate the polyubiquitination and disappearance of IL-1 receptor-associated kinase 1 (IRAK1) within minutes. It has been thought that the polyubiquitin chains attached to IRAK1 are linked via Lys48 of...
Authors: Windheim M, Stafford M, Peggie M, Cohen P

Glucocorticoid-related signaling effects in vascular smooth muscle cells

Mineralocorticoid receptor blockade protects from angiotensin II-induced target-organ damage. 11beta-Hydroxysteroid dehydrogenase type 2 protects the mineralocorticoid receptor from activation by glucocorticoids; however, high glucocorticoid...
Authors: Molnar GA, Lindschau C, Dubrovska G, Mertens PR, Kirsch T, Quinkler M, Gollasch M, Wresche S, Luft...

APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells

APOBEC3G (A3G), a member of cytidine deaminase family, has potent anti-human immunodeficiency virus type 1 (HIV-1) activity. It has been demonstrated that alpha interferon (IFN-alpha) can significantly enhance the expression of A3G in human primary...
Authors: Wang FX, Huang J, Zhang H, Ma X, Zhang H

NFAR-1 and -2 modulate translation and are required for efficient host defense

We report here that the alternatively spliced nuclear factors associated with double-stranded RNA, NFAR-1 (90 kDa) and -2 (110 kDa), are involved in retaining cellular transcripts in intranuclear foci and can regulate the export of mRNA to the...
Authors: Pfeifer I, Elsby R, Fernandez M, Faria PA, Nussenzveig DR, Lossos IS, Fontoura BM, Martin WD, Barber...

A novel CCCH-Zinc finger protein family regulates proinflammatory activation of macrophages

Activated macrophages play an important role in many inflammatory diseases. However, the molecular mechanisms controlling macrophage activation are not completely understood. Here we report that a novel CCCH zinc finger protein family MCPIP1, 2, 3...
Authors: Liang J, Wang J, Azfer A, Song W, Tromp G, Kolattukudy PE, Fu M

Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes

We previously demonstrated that trans-10, cis-12 (10,12) conjugated linoleic acid (CLA) causes human adipocyte delipidation, insulin resistance, and inflammation in part by attenuating PPARgamma target gene expression. We hypothesized that CLA...
Authors: Kennedy A, Chung S, LaPoint K, Fabiyi O, McIntosh MK

A Murine Model for Assessment of Plasmodium falciparum Transmission Blocking Vaccine using Transgenic Plasmodium berghei Parasites Expressing the target antigen Pfs25

Currently, there is no animal model for Plasmodium falciparum challenge to evaluate malaria transmission blocking vaccines (TBV) based on well established Pfs25 target antigen. The biological activity of transmission blocking antibodies is assessed...
Authors: Mlambo G, Maciel J, Kumar N

The constitutively active orphan G-protein coupled receptor GPR39 protects from cell death by increasing secretion of pigment-epithelial derived growth factor PEDF

GPR39 is a constitutively active orphan G-protein-coupled receptor capable of increasing serum-response-element mediated transcription. We found GPR39 to be upregulated in a hippocampal cell line resistant against diverse stimulators of cell death...
Authors: Dittmer S, Sahin M, Pantlen A, Saxena A, Toutzaris D, Pina AL, Geerts A, Golz S, Methner A

Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression

We previously reported the importance of the serum response factor (SRF) cofactor myocardin in controlling muscle gene expression as well as the fundamental role for the inflammatory transcription factor NF-kappaB in governing cellular fate....
Authors: Tang RH, Zheng XL, Callis TE, Stansfield WE, He J, Baldwin AS, Wang DZ, Selzman CH

Cross-recognition of avian H5N1 influenza virus by human cytotoxic T lymphocyte populations directed to human influenza A virus

Since the number of human cases of infection with avian H5N1 influenza viruses is ever increasing, a pandemic outbreak caused by these viruses is feared. Therefore, in addition to virus-specific antibodies, there is considerable interest in immune...
Authors: Kreijtz J, de Mutsert G, van Baalen C, Fouchier R, Osterhaus A, Rimmelzwaan G