Search Results

Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm.

BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of ultrastructural defects of the axoneme underlie the disease, which is characterised by chronic...

Authors: Onoufriadis A1, Shoemark A, Munye MM, James CT, Schmidts M, Patel M, Rosser EM, Bacchelli C, Beales...

Stimulated bronchial epithelial cells release bioactive lysophosphatidylcholine 16:0, 18:0, and 18:1.

PURPOSE: In human subjects and animal models with acute and chronic lung injury, the bioactive lysophosphatidylcholine (LPC) is elevated in lung lining fluids. The increased LPC can promote an inflammatory microenvironment resulting in lung injury....

Authors: Zhuge Y1, Yuan Y2, van Breemen R2, Degrand M1, Holian O1, Yoder M3, Lum H1.

SST Peer Reviewed

Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure

BACKGROUND: Extracellular vesicle (EV) trafficking is a fundamental cellular process that occurs in cells and is required for different aspects of pathophysiology. EV trafficking leads to changes in cellular function including apoptosis, angiogenesis...

Authors: Panagopoulos K1, Cross-Knorr S, Dillard C, Pantazatos D, Del Tatto M, Mills D, Goldstein L, Renzulli...

The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells

The Rho family of small GTPases control cell migration, cell invasion and cell cycle. Many of these processes are perturbed in cancer and several family members show altered expression in a number of tumor types. RhoBTB2/DBC2 is an atypical member of...

Authors: McKinnon CM1, Lygoe KA, Skelton L, Mitter R, Mellor H.

Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth

The Mediterranean diet has long been attributed to preventing or delaying the onset of cardiovascular disease, diabetes and various solid organ cancers. In this particular study, a rosemary extract standardized to carnosic acid was evaluated for its...

Authors: Petiwala SM1, Berhe S1, Li G1, Puthenveetil AG1, Rahman O1, Nonn L2, Johnson JJ

The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors.

We sought to identify fibroblast growth factor receptor 2 (FGFR2) kinase domain mutations that confer resistance to the pan-FGFR inhibitor, dovitinib, and explore the mechanism of action of the drug-resistant mutations. We cultured BaF3 cells...

Authors: Byron SA1, Chen H, Wortmann A, Loch D, Gartside MG, Dehkhoda F, Blais SP, Neubert TA, Mohammadi M,...

Unliganded estrogen receptor alpha promotes PC12 survival during serum starvation

Many studies have reported proliferative, differentiating or protective effects of estradiol, notably through estrogen receptor alpha (ERa). On the contrary, the ligand-independent action of ERa is currently poorly documented notably in cell...

Authors: Ferriere F1, Habauzit D, Pakdel F, Saligaut C, Flouriot G

Context-specific roles for paracrine IL-6 in lymphomagenesis.

A basic requirement for the development of complex organ systems is that the cellular response to identical environmental cues can vary significantly between distinct cell types and developmental stages. While it is well established that paracrine...

Authors: Gilbert LA1, Hemann MT.

Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.

Trypsin or Tumor associated trypsin (TAT) activation of Protease-activated receptor 2 (PAR-2) promotes tumor cell proliferation in gastrointestinal cancers. The role of the trypsin/PAR-2 network in esophageal adenocarcinoma (EA) development has not...

Authors: Han S1, Lee CW, Trevino JG, Hughes SJ, Sarosi GA Jr

Cross talk between engulfment receptors stabilin-2 and integrin avß5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes.

Efficient cell corpse clearance is critical for health in organisms. Apoptotic cells displaying phosphatidylserine (PS) are recognized by engulfment receptors and ingested through two conserved pathways. In one pathway, engulfment receptor...

Authors: Kim S1, Park SY, Kim SY, Bae DJ, Pyo JH, Hong M, Kim IS.

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