Search Results

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1...

Authors: Glading A, Han J, Stockton RA, Ginsberg MH

SST Peer Reviewed

Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

A recently discovered phosphatidylinositol monophosphate, phosphatidylinositol 5-phosphate (PtdIns-5-P), plays an important role in nuclear signaling by influencing p53-dependent apoptosis. It interacts with a plant homeodomain finger of inhibitor of...

Authors: Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW

Distinct Pathways for the Early Recruitment of Myosin II and Actin to the Cytokinetic Furrow

Equatorial organization of myosin II and actin has been recognized as a universal event in cytokinesis of animal cells. Current models for the formation of equatorial cortex favor either directional cortical transport toward the equator, or localized...

Authors: Zhou M, Wang YL

Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization

The schizophrenia susceptibility gene dystrobrevin-binding protein 1 (DTNBP1) encodes dysbindin, which along with its binding partner Muted is an essential component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Dysbindin...

Authors: Iizuka Y, Sei Y, Weinberger DR, Straub RE

PPAR-alpha contributes to the anti-inflammatory activity of glucocorticoids

Glucocorticoids (GCs) are effective anti-inflammatory agents widely used in therapeutic approach to treatment of acute and chronic inflammatory diseases. Previous results suggest that Peroxisome proliferator activated receptor alpha-alpha...

Authors: Cuzzocrea S, Bruscoli S, Mazzon E, Crisafulli C, Donato V, Di Paola R, Velardi E, Esposito E,...

Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress

Pulse-treatment of U-937 human promonocytic cells with cadmium chloride followed by recovery caused caspase-9/caspase-3-dependent, caspase-8-independent apoptosis. However, pre-incubation with the glutathione (GSH)-suppressing agent...

Authors: Sancho P, Fernandez C, Yuste VJ, Amran D, Ramos AM, de Blas E, Susin SA, Aller P

Transfection of the protozoan parasite Perkinsus marinus

Ongoing efforts for sequencing the genome of the protozoan parasite Perkinsus marinus, together with functional genomic initiatives, have continued to provide invaluable information about genes and metabolic pathways that not only will increase our...

Authors: Fernandez-Robledo JA, Lin Z, Vasta GR

CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells

OBJECTIVE: Oxidative stress contributes to the inflammatory properties of rheumatoid arthritis (RA) synovial T lymphocytes. This study was undertaken to investigate the mechanisms leading to production of reactive oxygen species (ROS) and oxidative...

Authors: Remans PH, Wijbrandts CA, Sanders ME, Toes RE, Breedveld FC, Tak PP, van Laar JM, Reedquist KA

High-efficiency transfection of mammalian neurons via nucleofection

Transfection of foreign DNA is widely used to study gene function. However, despite the development of numerous methods, the transfer of DNA into postmitotic cells, such as neurons, remains unsatisfactory with regard to either transfection efficiency...

Authors: Zeitelhofer M, Vessey JP, Xie Y, Tübing F, Thomas S, Kiebler M, Dahm R

SST Peer Reviewed

BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors

During development, coordinate regulation of cell cycle exit and differentiation of neuronal precursors is essential for generation of appropriate number of neurons and proper wiring of neuronal circuits. BM88 is a neuronal protein associated in vivo...

Authors: Politis PK, Makri G, Thomaidou D, Geissen M, Rohrer H, Matsas R

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