Search Results

Novel c-CBL and CBL-B ubiquitin ligase mutations in human acute myeloid leukemia

The CBL ubiquitin ligase targets a variety of activated tyrosine kinases (TK) for degradation. Many TKs are mutationally or autocrine-activated and/or often over-expressed at the mRNA and protein levels in acute leukemias. We hypothesized that CBL is...

Authors: Caligiuri MA, Briesewitz R, Yu J, Wang L, Wei M, Arnoczky KJ, Marburger TB, Wen J, Perrotti D,...

Gene expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt's lymphoma cell lines and primary tumors

Burkitt lymphoma (BL) is a B-cell tumor whose characteristic gene aberration is the translocation t(8;14), which determines c-myc overexpression. Several genetic and epigenetic alterations, other than c-myc overexpression, have also been described in...

Authors: De Falco G, Leucci E, Lenze D, Piccaluga PP, Claudio PP, Onnis A, Cerino G, Nyagol J, Mwanda W,...

Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs

The control of IL-12 production from dendritic cells (DCs) and macrophages in response to Mycobacterium tuberculosis (Mtb) is not well understood. The objective of this study was to pursue the mechanism underlying our previous report that in response...

Authors: Pompei L, Jang S, Zamlynny B, Ravikumar S, McBride A, Hickman SP, Salgame P

Adrenaline increases glucose transport via a Rap1-p38MAPK pathway in rat vascular smooth muscle cells

Background and purpose:Adrenaline has been implicated in the pathogenesis of atherosclerosis. However, little is known regarding the role of adrenaline in glucose transport in VSMC.Experimental approach:In this study, we examined the effects of...

Authors: Kanda Y, Watanabe Y

Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)], initiates neurotransmitter release and promotes delayed cell death

The transient receptor potential (TRP) vanilloid receptor subtype 1 (TRPV1) is a ligand-gated, Ca(2+)-permeable ion channel in the TRP superfamily of channels. We report the establishment of the first neuronal model expressing recombinant human TRPV1...

Authors: Lam PM, Hainsworth AH, Smith GD, Owen DE, Davies J, Lambert DG

SST Peer Reviewed

TRPC channels promote cerebellar granule neuron survival

Channels formed by the transient receptor potential (TRP) family of proteins have a variety of physiological functions. Here we report that two members of the TRP cation channel (TRPC) subfamily, TRPC3 and 6, protected cerebellar granule neurons...

Authors: Jia Y, Zhou J, Tai Y, Wang Y

The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages

It is hypothesized that the anti-inflammatory actions of peroxisome proliferator-activated receptors (PPARs) may explain the protective effect of these receptors in diabetes, atherosclerosis, cancer and other inflammatory diseases. However, emerging...

Authors: Hall JM, McDonnell DP

Loss of fibulin-2 expression is associated with breast cancer progression

Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by...

Authors: Yi CH, Smith DJ, West WW, Hollingsworth MA

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2

Ras activation as a consequence of antigen receptor (T-cell receptor; TCR) engagement on T lymphocytes is required for T-cell development, selection and function. Lymphocyte function-associated antigen-1 (LFA-1) mediates lymphocyte adhesion,...

Authors: Mor A, Campi G, Du G, Zheng Y, Foster DA, Dustin ML, Philips MR

Epstein-Barr Virus (EBV) Latent Membrane Protein-1 Down-Regulates Tumor Necrosis Factor- (TNF-) Receptor-1 and Confers Resistance to TNF--Induced Apoptosis in T Cells: Implication for the Progression to T-Cell Lymphoma in EBV-Associated Hemophagocytic Syndrome

The infection of T cells by Epstein-Barr virus (EBV) may result in hemophagocytic syndrome (HPS) through enhanced cytokine secretion, particularly tumor necrosis factor-alpha (TNF-alpha), by EBV latent membrane protein-1 (LMP-1). One bewildering...

Authors: Chuang HC, Lay JD, Chuang SE, Hsieh WC, Chang Y, Su IJ

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