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BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer

Screening for tumor suppressor genes in breast cancer revealed multiple truncating mutations of PB1, which encodes the BAF180 subunit of the PBAF chromatin remodeling complex. Mutation was associated with loss of heterozygosity of the wild-type...

Authors: Xia W, Nagase S, Montia AG, Kalachikov SM, Keniry M, Su T, Memeo L, Hibshoosh H, Parsons R

The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment

During vertebrate cell division, chromosomes oscillate with periods of smooth motion interrupted by abrupt reversals in direction. These oscillations must be spatially constrained in order to align and segregate chromosomes with high fidelity, but...

Authors: Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L

Radiation Enhances Adenoviral Gene Therapy in Pancreatic Cancer via Activation of Cytomegalovirus Promoter and Increased Adenovirus Uptake

PURPOSE: Adenovirus-mediated gene therapy combined with radiation is expected to be a new approach to treat pancreatic cancer. However, there are no reports of definitive effects of radiation on adenovirus-mediated gene therapies. In the present...

Authors: Egami T, Ohuchida K, Mizumoto K, Onimaru M, Toma H, Nishio S, Nagai E, Matsumoto K, Nakamura T,...

Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITP-alpha during axonal extension in hippocampal neurons

Phosphatidylinositol transfer proteins (PITPs) mediate the transfer of phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) between two membrane compartments, thereby regulating the interface between signalling, phosphoinositide (PI)...

Authors: Cosker KE, Shadan S, van Diepen M, Morgan C, Li M, Allen-Baume V, Hobbs C, Doherty P, Cockcroft S,...

p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression

Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the...

Authors: Choi BH, Kim CG, Bae YS, Lim Y, Lee YH, Shin SY

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation

Protein phosphatase 4 catalytic subunit (PP4c) is a PP2A-related protein serine/threonine phosphatase with important functions in a variety of cellular processes, including microtubule (MT) growth/organization, apoptosis, and tumor necrosis factor...

Authors: Toyo-Oka K, Mori D, Yano Y, Shiota M, Iwao H, Goto H, Inagaki M, Hiraiwa N, Muramatsu M,...

Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling

Several histone deacetylases (HDAC) are involved in estrogen receptor (ER)-mediated gene transactivation, and HDAC inhibitors have been reported to restore sensitivity to antihormonal therapy. The modulation of ER is the most promising approach to...

Authors: Bicaku E, Marchion DC, Schmitt ML, Münster PN

Etk/BMX, a Btk Family Tyrosine Kinase, and Mal Contribute to the Cross-Talk between MyD88 and FAK Pathways

MyD88 and focal adhesion kinase (FAK) are key adaptors involved in signaling downstream of TLR2, TLR4, and integrin alpha(5)beta(1), linking pathogen-associated molecule detection to the initiation of proinflammatory response. The MyD88 and integrin...

Authors: Semaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions

Knockdown of the insulator factor CCCTC binding factor (CTCF), which binds XL9, an intergenic element located between HLA-DRB1 and HLA-DQA1, was found to diminish expression of these genes. The mechanism involved interactions between CTCF and class...

Authors: Majumder P, Gomez JA, Chadwick BP, Boss JM

Lys (K)63-linked polyubiquitination of IRAK-1 is required for IL-1 receptor- and Toll-like receptor-mediated NF-kappaB activation

Stimulation through the IL-1 receptor (IL-1R) and some Toll-like receptors (TLRs) induces ubiquitination of TRAF6 and IRAK-1, signaling components required for NF-kappa B and MAP kinase activation. Here we show that although TRAF6 and IRAK-1 acquired...

Authors: Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD

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