The CBL ubiquitin ligase targets a variety of activated tyrosine kinases (TK) for degradation. Many TKs are mutationally or autocrine-activated and/or often over-expressed at the mRNA and protein levels in acute leukemias. We hypothesized that CBL is...
Authors: Caligiuri MA, Briesewitz R, Yu J, Wang L, Wei M, Arnoczky KJ, Marburger TB, Wen J, Perrotti D,...