Search Results

Dishevelled promotes axon differentiation by regulating atypical protein kinase C

The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown. Here, we report that in cultured hippocampal...

Authors: Zhang X, Zhu J, Yang GY, Wang QJ, Qian L, Chen YM, Chen F, Tao Y, Hu HS, Wang T, Luo ZG

Epigenetic regulation of tumor necrosis factor alpha

Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message...

Authors: Sullivan KE, Reddy AB, Dietzmann K, Suriano AR, Kocieda VP, Stewart M, Bhatia M

BMP4 Induces HO-1 via a Smad-Independent, p38MAPK-Dependent Pathway in Pulmonary Artery Myocytes

Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which play a key role in vascular development and remodeling. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, has been shown to be protective against vascular and...

Authors: Yang X, Lee PJ, Long L, Trembath RC, Morrell NW

Thiazolidinediones Modulate the Expression of -Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box Proteins of SCF E3 Ubiquitin Ligase Independently of PPAR

Thiazolidinediones Modulate the Expression of beta-Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box ProtConsidering the role of aberrant beta-catenin signaling in tumorigenesis, we investigated the mechanism by which the...

Authors: Wei S, Lin LF, Yang CC, Wang YC, Chang GD, Chen H, Chen CS

Expression of The P16ink4a Gene Is Associated Closely with Senescence of Human Mesenchymal Stem Cells, and Potentially Silenced by DNA Methylation During In Vitro Expansion

The precise biological characteristics of human mesenchymal stem cells (hMSCs), including growth regulatory mechanisms, have not yet been defined. Using 29 strains of hMSCs isolated from bone marrow, we have performed extensive analyses of the growth...

Authors: Shibata K, Aoyama T, Shima Y, Fukiage K, Otsuka S, Furu M, Kohno Y, Ito K, Fujibayashi S, Neo M,...

Syk-dependent Actin Dynamics Regulate Endocytic Trafficking and Processing of Antigens Internalized through the B Cell Receptor

Antigen binding to the B-cell receptor (BCR) induces multiple signaling cascades that ultimately lead to B lymphocyte activation. In addition, the BCR regulates the key trafficking events that allow the antigen to reach endocytic compartments devoted...

Authors: Le Roux D, Lankar D, Yuseff MI, Vascotto F, Yokozeki T, Faure-André G, Mougneau E, Glaichenhaus N,...

Cytotoxic phospholipid oxidation products: Cell death from mitochondrial damage and the intrinsic caspase cascade

Phospholipid oxidation products accumulate in the necrotic core of atherosclerotic lesions, in apoptotic cells, and circulate in oxidized LDL. Phospholipid oxidation generates toxic products, but little is known about which specific products are...

Authors: Chen R, Yang L, McIntyre TM

Impaired th1/tc1 cytokine production of tumor-infiltrating lymphocytes in a model of primary intraocular B-cell lymphoma

PURPOSE: Primary intraocular lymphoma is a high-grade non-Hodgkin lymphoma with a pathogenesis that is still unclear. Microenvironment is known to be crucial in controlling tumor growth and maintenance. To study the immune microenvironment in...

Authors: Touitou V, Daussy C, Bodaghi B, Camelo S, de Kozak Y, Lehoang P, Naud MC, Varin A,...

Pivotal Advance: Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells

Slit, which mediates its function by binding to the Roundabout (Robo) receptor, has been shown to regulate neuronal, dendritic, and leukocyte migration. However, the molecular mechanism by which the Slit/Robo complex inhibits the migration of cells...

Authors: Prasad A, Qamri Z, Wu J, Ganju RK

The cytosolic protein talin induces an intermediate affinity integrin alphaLbeta2

The integrin alpha(L)beta(2) mediates leukocyte adhesion and migration that are required for a functional immune system. It is known that inside-out signaling triggers alpha(L)beta(2) conformational changes, which affect its ligand-binding affinity....

Authors: Li YF, Tang RH, Puan KJ, Law SK, Tan SM

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