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Different approaches for assaying melanosome transfer

Many approaches have been tried to establish assays for melanosome transfer to keratinocytes. In this report, we describe and summarize various novel attempts to label melanosomes in search of a reliable, specific, reproducible and quantitative assay...

Authors: Berens W, Van Den Bossche K, Yoon TJ, Westbroek W, Valencia JC, Out CJ, Marie Naeyaert J, Hearing VJ...

Characterization of the infectious salmon anemia virus fusion protein

Infectious salmon anemia virus (ISAV) is an orthomyxovirus causing serious disease in Atlantic salmon (Salmo salar L.). This study presents the characterization of the ISAV 50-kDa glycoprotein encoded by segment 5, here termed the viral membrane...

Authors: Aspehaug V, Mikalsen AB, Snow M, Biering E and Villoing S

Replication of Minute Virus of Mice DNA Is Critically Dependent on Accumulated Levels of NS2

Following transfection of murine fibroblasts, the lymphotropic strain of minute virus of mice (MVMi) does not efficiently produce progeny single-strand DNA (ssDNA). However, changing a single nucleotide in the MVMi 3' splice site to that found in the...

Authors: Choi EY, Newman AE, Burger L and Pintel D

PKCepsilon controls protection against TRAIL in erythroid progenitors

Apoptosis plays a central role in the regulation of the size of the hematopoietic stem cell pool as well as in the processes of cell differentiation along the various hematopoietic lineages. TRAIL is a member of the TNF family of cytokines with a...

Authors: Mirandola P, Gobbi G, Ponti C, Sponzilli I, Cocco L and Vitale M

Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a multifunctional tumor suppressor, has been shown to play a regulatory role in cell migration. Dictyostelium discoideum cells lacking PTEN exhibited impaired migration toward...

Authors: Gao P, Wange RL, Zhang N, Oppenheim JJ and Howard OM

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

Mantle Cell Lymphoma (MCL) is a mature B-cell lymphoma with an aggressive course and generally poor prognosis. Conventional chemotherapy has little efficacy. Bortezomib (PS-341, Velcade (R)) is a novel, reversible and high specific proteasome...

Authors: Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E and Colomer D

Immediate and delayed effects of e-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells

The invasion suppressor protein, E-cadherin, plays a central role in epithelial cell-cell adhesion. Loss of E-cadherin expression or function in various tumors of epithelial origin is associated with a more invasive phenotype. In this study, by...

Authors: Andersen H, Mejlvang J, Mahmood S, Gromova I, Gromov P, Lukanidin E, Kriajevska M, Mellon JK and...

cAMP-induced PKC activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors

Chemokines are key regulators of hematopoiesis and host defense. We report here that a functional expression of the chemokine receptor CXCR4 on human immature CD34(+) hematopoietic progenitors was increased as a result of sustained elevation in...

Authors: Goichberg P, Kalinkovich A, Borodovsky N, Tesio M, Petit I, Nagler A, Hardan I and Lapidot T

Cdc42 and Par6-PKC regulate the spatially localized association of Dlg1 and APC to control cell polarization

Cell polarization is essential in a wide range of biological processes such as morphogenesis, asymmetric division, and directed migration. In this study, we show that two tumor suppressor proteins, adenomatous polyposis coli (APC) and Dlg1-SAP97, are...

Authors: Etienne-Manneville S, Manneville JB, Nicholls S, Ferenczi MA and Hall A

Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has emerged as a novel anticancer agent. Previously, we showed that although most adult T-cell...

Authors: Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Yoshida T, Sakai T, Koyano T, Kam TS,...

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