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Imaging antigen-induced PI3K activation in T cells

Imaging antigen-induced PI3K activation in T cells. Harriague J, Bismuth G. Departement de Biologie Cellulaire, Institut Cochin, INSERM U567, CNRS UMR 7627, Universite Rene Descartes, 22 rue Mechain, 75014 Paris, France. Activation of...

Authors: Harriague J and Bismuth G

Regulation of Bcl-2 expression by C/EBP in t(14;18) lymphoma cells

In follicular lymphomas with the t(14;18) translocation, there is increased expression of the bcl-2 gene, which is dependent upon regulatory elements within the bcl-2 5' flanking region and the immunoglobulin heavy-chain gene enhancers. We found that...

Authors: Heckman CA, Wheeler MA and Boxer LM

Disruption of basal JNK activity differentially affects key fibroblast function important for wound healing

We used both a gene knockout approach and pharmacologic modulation to study the implication of the JNK pathway in regulating fibroblast motility, capacity to contract mechanically unloaded collagen gels, and type I collagen gene expression in vitro....

Authors: Javelaud D, Laboureau J, Gabison E, Verrecchia F and Mauviel A

Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site-mediated translation via phosphatidylinositol 3-kinase pathway in human factor-dependent leukemic cells

Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site-mediated translation via phosphatidylinositol 3-kinase pathway in human...

Authors: Kobayashi N, Saeki K and Yuo A

Recognition of a novel stage of betaherpesvirus latency in human herpesvirus 6

Latency-associated transcripts of human herpesvirus 6 (H6LTs) (K. Kondo et al. J. Virol. 76:4145-4151, 2002) were maximally expressed at a fairly stable intermediate stage between latency and reactivation both in vivo and in vitro. H6LTs functioned...

Authors: Kondo K, Sashhara J, Shimada K, Takemoto M, Amo K, Miyagawa H and Yamanishi K

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type I gamma

Clathrin-mediated endocytosis of synaptic vesicle membranes involves the recruitment of clathrin and AP-2 adaptor complexes to the presynaptic plasma membrane. Phosphoinositides have been implicated in nucleating coat assembly by directly binding to...

Authors: Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K and Haucke V

Histamine enhances TGF-beta1-mediated suppression of TH2 responses

Susceptibility of T cells to TGF-beta1 produced by regulatory T cells has an important impact on the induction and maintenance of peripheral tolerance and therefore on the development of autoimmunity, cancer, and allergy. Histamine not only mediates...

Authors: Kunzmann S, Mantel PY, Wohlfahrt JG, Akdis CA, Blaser K and Schmidt-Weber CB

SARA and Hgs attenuate susceptibility to TGF-beta1-mediated T cell supression

Transforming growth factor-beta1 (TGF-beta1) is a pluripotent cytokine that controls peripheral T cell tolerance mainly in mucosal immunity. It is secreted by regulatory T cells (Tr /Th3) but also by other immununologically active cells. Smad anchor...

Authors: Kunzmann S, Wohlfahrt JG, Itoh S, Asao H, Komada M, Akdis CA, Blaser K and Schmidt-Weber CB

IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages

Interleukin-10 (IL-10) plays an important role in prevention of chronic inflammation in vivo. However, the molecular mechanism by which IL-10 exerts its anti-inflammatory response is poorly understood. Here, we performed a microarray analysis and...

Authors: Kuwata H, Watanabe Y, Miyoshi H, Yamamoto M, Kaisho T, Takeda K and Akira S

Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax

Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. The HTLV-I transactivator protein Tax plays an integral role in the etiology of adult T cell...

Authors: Alefantis T, Barmak K, Harhaj E, Grant C and Wigdahl B

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