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Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma

A broad range of malignant diseases, such as mantle cell lymphoma (MCL), is associated with complex genomic alterations, demanding multimodal functional testing of candidate genes. To assess such candidate disease genes, we have developed a...

Authors: Pscherer A, Schliwka J, Wildenberger K, Mincheva A, Schwaenen C, Dohner H, Stilgenbauer S, Lichter...

Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation

We have shown previously that caspases were specifically involved in the differentiation of peripheral blood monocytes into macrophages while not required for monocyte differentiation into dendritic cells. To identify caspase targets in monocytes...

Authors: Cathelin S, Rebe C, Haddaoui L, Simioni N, Verdier F, Fontenay M, Launay S, Mayeux P, Solary E

Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

17-Allylamino-demethoxy geldanamycin (17-AAG) inhibits the chaperone association of heat shock protein 90 (hsp90) with the heat shock factor-1 (HSF-1), which induces the mRNA and protein levels of hsp70. Increased hsp70 levels inhibit death receptor...

Authors: Guo F, Rocha K, Bali P, Pranpat M, Fiskus W, Boyapalle S, Kumaraswamy S, Balasis M, Greedy B,...

The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression

The IR2 protein (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich tract and yet retaining binding domains for DNA and TFIIB and nuclear localization...

Authors: Kim SK, Ahn BC, Albrecht RA, O'callaghan DJ

Biphasic regulation by bile acids of dermal fibroblast proliferation through regulation of cAMP production and COX-2 expression level

We have previously reported that the bile acids chenodeoxycholate (CDCA), and ursodeoxycholate (UDCA), decreased PGE1-induced cAMP production not only in hepatocytes but also in non-hepatic cells including dermal fibroblasts. In the present study we...

Authors: Meng J, Ceryak S, Arastu Z, Jones L, Epstein L, Bouscarel B

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Disease-producing mutations of ion channels are usually characterized as producing hyperexcitability or hypoexcitability. We show here that a single mutation can produce hyperexcitability in one neuronal cell type and hypoexcitability in another...

Authors: Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG

Cytoplasmic IRE1alpha -mediated XBP1 mRNA splicing in the absence of nuclear processing and ER stress

Accumulation of unfolded proteins in the endoplasmic reticulum activates an intracellular signal transduction program termed the Unfolded Protein Response (UPR). In mammalian cells, the UPR is signaled in part through dimerization of ER...

Authors: Back SH, Lee K, Vink E, Kaufman RJ

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent

Authors: Tonelli R, Sartini R, Fronza R, Freccero F, Franzoni M, Dongiovanni D, Ballarini M, Ferrari S,...

Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells

We studied the effects of Lyn ablation on CXCR4 receptor-mediated migration and adhesion of hematopoietic precursors. Down-regulation of Lyn expression with siRNA greatly reduced CXCR4-dependent hematopoietic cell movement, and increased cell...

Authors: Nakata Y, Tomkowicz B, Gewirtz AM, Ptasznik A

MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer

Mammary tumor cells are required to degrade the surrounding matrix and disseminate in order to metastasize, and both of these processes are controlled by a tumor cell-signaling network that remains poorly defined. MEKK1 is a MAPKKK that regulates...

Authors: Cuevas BD, Winter-Vann AM, Johnson NL, Johnson GL

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