Search Results

CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling

In mammals, beta1 integrin adhesion receptors generate signals that mediate cell spreading, migration, proliferation, and survival. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin beta subunit cytoplasmic...

Authors: Prager GW, Feral CC, Kim C, Han J, Ginsberg MH

Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection

Malaria infection starts when sporozoites are transmitted to the mammalian host during a mosquito bite. Sporozoites enter the blood circulation, reach the liver and infect hepatocytes. The formation of a parasitophorous vacuole (PV), establishes...

Authors: Labaied M, Harupa A, Dumpit RF, Coppens I, Mikolajczak SA, Kappe SH

Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects

Niemann-Pick C (NPC) disease is an autosomal recessive lipid storage disorder characterized by a disruption of sphingolipid and cholesterol trafficking that produces cognitive impairment, ataxia and death, often in childhood. Most cases are caused by...

Authors: Pacheco CD, Kunkel R, Lieberman AP

In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents

Progressive fibrosis is a cause of progressive organ dysfunction. Lack of quantitative in vitro models of fibrosis accounts, at least partially, for the slow progress in developing effective anti-fibrotic drugs. Here we report two complementary in...

Authors: Xu Q, Norman JT, Shrivastav S, Lucio-Cazana J, Kopp JB

SST Peer Reviewed

Evaluation of the Biological Activity of a GH Mutant (R77C) and its Impact on GH Responsiveness and Stature

Context and Objective: A single missense mutation in the GH-1 gene converting codon 77 from arginine (R) to cysteine (C) yields a mutant GH-R77C peptide, which was described as natural growth hormone antagonist. Design, Setting, Patients:...

Authors: Petkovic V, Besson A, Thevis M, Lochmatter D, Eblé A, Flück CE, Mullis PE

Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions

In epithelial cells, tight junctions (TJs) and adherens junctions (AJs) form junctional complexes. At AJs, cadherins and nectins are the major cell-cell adhesion molecules. Nectins first form cell-cell adhesions and then recruit cadherins to the...

Authors: Ozaki M, Ogita H, Takai Y

The localization and activity of sphingosine kinase 1 are coordinately-regulated with actin cytoskeletal dynamics in macrophages

The physiologic and pathologic functions of sphingosine kinase (SK)1 require translocation to specific membrane compartments. We tested the hypothesis that interactions with actin filaments regulate the localization of SK1 to membrane surfaces;...

Authors: Kusner DJ, Thompson CR, Melrose NA, Pitson SM, Obeid LM, Iyer SS

SST Peer Reviewed

Epigenetic regulation of tumor necrosis factor alpha

Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message...

Authors: Sullivan KE, Reddy AB, Dietzmann K, Suriano AR, Kocieda VP, Stewart M, Bhatia M

BMP4 Induces HO-1 via a Smad-Independent, p38MAPK-Dependent Pathway in Pulmonary Artery Myocytes

Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which play a key role in vascular development and remodeling. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, has been shown to be protective against vascular and...

Authors: Yang X, Lee PJ, Long L, Trembath RC, Morrell NW

Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming

The use of recombinant tumor antigen proteins is a realistic approach for the development of generic cancer vaccines, but the potential of this type of vaccines to induce specific CD8(+) T cell responses, through in vivo cross-priming, has remained...

Authors: Valmori D, Souleimanian NE, Tosello V, Bhardwaj N, Adams S, O'neill D, Pavlick A, Escalon JB, Cruz...

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