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4894 results sorted by

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70

Barbiturates, which are used for the treatment of intracranial hypertension after severe head injury, have been associated with anti-inflammatory side effects. While all barbiturates inhibit T cell function, only thiobarbiturates markedly reduce the...
Authors: Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL,...
SST Peer Reviewed

Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion

Multiple factors alter intervertebral disc volume, structure, shape, composition, and biomechanical properties, often leading to low back pain. Spinal fusion is frequently performed to treat this problem. We recently published results of our...
Authors: Sheyn D, Pelled G, Zilberman Y, Talasazan F, Frank JM, Gazit D, Gazit Z
SST Peer Reviewed

MicroRNA-21 Increases Aldosterone Secretion and Proliferation in H295R Human Adrenocortical Cells

MicroRNAs (miRNAs) are endogenous small non-coding RNAs which decrease the expression levels of specific genes by translational repression, sequestration and degradation of their mRNAs. Angiotensin II is an important modulator of adrenal zona...
Authors: Romero DG, Plonczynski MW, Carvajal CA, Gomez-Sanchez EP, Gomez-Sanchez CE

Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model

The intensity of the total choline (tCho) signal in spectroscopic images of tumors is spatially heterogeneous. The likewise heterogeneous physiologic tumor microenvironment may contribute to this heterogeneity. We therefore investigated the...
Authors: Glunde K, Shah T, Winnard PT Jr, Raman V, Takagi T, Vesuna F, Artemov D, Bhujwalla ZM

Bifunctional Role of Rev-erb alpha in Adipocyte Differentiation

The nuclear receptor Rev-erbalpha is a potent transcriptional repressor that regulates circadian rhythm and metabolism. Here we demonstrate a dissociation between Rev-erbalpha mRNA and protein levels that profoundly influences adipocyte...
Authors: Wang J, Lazar MA

The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches

Neurons express two different microtubule-severing proteins, namely P60-katanin and spastin. Here, we performed studies on cultured neurons to ascertain whether these two proteins participate differently in axonal branch formation. P60-katanin is...
Authors: Yu W, Qiang L, Solowska JM, Karabay A, Korulu S, Baas PW

Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors

Human NKG2D/DAP10 is an activation receptor expressed by NK and subsets of T cells, whose ligands include MHC class I chain-related (MIC) protein A and protein B and UL16-binding proteins that are often up-regulated by stress or pathological...
Authors: Marusina AI, Burgess SJ, Pathmanathan I, Borrego F, Coligan JE

How cells tiptoe on adhesive surfaces before sticking

Cell membranes are studded with protrusions that were thoroughly analyzed with electron microscopy. However, the nanometer-scale three-dimensional motions generated by cell membranes to fit the topography of foreign surfaces and initiate adhesion...
Authors: Pierres A, Benoliel AM, Touchard D, Bongrand P

HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein (DIP)

The HIV-1 protein Nef's ability to induce cytoskeleton changes in infected host cells is a key event in viral replication. In renal podocytes, we found that Nef induced loss of stress fibers and increased lamellipodia, pathological changes leading to...
Authors: Lu TC, He JC, Wang Z, Feng X, Fukumi-Tominaga T, Chen N, Xu J, Iyengar R, Klotman PE

Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behܧet's disease

INTRODUCTION: Toll-like receptors (TLRs) mediate signaling that triggers activation of the innate immune system, whereas heme oxygenase (HO)-1 (an inducible heme-degrading enzyme that is induced by various stresses) suppresses inflammatory responses....
Authors: Kirino Y, Takeno M, Watanabe R, Murakami S, Kobayashi M, Ideguchi H, Ihata A, Ohno S, Ueda A, Mizuki...
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