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17Beta-estradiol attenuates PDGF signaling in vascular smooth muscle cells at the postreceptor level

Estrogens are known to display significant vasoprotective effects in premenopausal women. PDGF is an important mediator of vascular smooth muscle cell (VSMC) migration and proliferation, and thus atherogenesis. We analyzed the effects of...
Authors: Kappert K, Caglayan E, Huntgeburth M, Baumer AT, Sparwel J, Uebel M and Rosenkranz S

A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway

Distinct intracellular pathways are involved in regulated and constitutive protein secretion from neuronal and endocrine cells, yet the peptide signals and molecular mechanisms responsible for targeting and retention of soluble proteins in secretory...
Authors: Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL and Salton SR

A Novel Role for Glucocorticoid-induced Leucine Zipper Protein in Epithelial Sodium Channel-mediated Sodium Transport

The steroid hormone aldosterone stimulates sodium (Na+) transport in tight epithelia by altering the expression of target genes that regulate the activity and trafficking of the epithelial sodium channel (ENaC). We performed microarray analysis to...
Authors: Soundararajan R, Zhang TT, Wang J, Vandewalle A and Pearce D

Transforming Growth Factor 1 Induces Nox 4 NAD(P)H Oxidase and Reactive Oxygen Species-Dependent Proliferation in Human Pulmonary Artery Smooth Muscle Cells

Transforming growth factor beta1 (TGFbeta1) is abundantly expressed in pulmonary hypertension, but its effect on the pulmonary circulation remain unsettled. We therefore studied TGFbeta1 stimulation of freshly isolated human pulmonary artery smooth...
Authors: Sturrock A, Cahill B, Norman K, Huecksteadt TP, Hill K, Sanders K, Karwande SV, Stringham JC, Bull...

Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors

Testosterone supplementation in men decreases fat mass; however, the mechanisms by which it inhibits fat mass are unknown. We hypothesized that testosterone inhibits adipogenic differentiation of preadipocytes by activation of androgen receptor...
Authors: Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF and Bhasin S

A Novel Endocytic Recycling Signal Distinguishes Biological Responses of Trk Neurotrophin Receptors

Endocytic trafficking of signaling receptors to alternate intracellular pathways has been shown to lead to diverse biological consequences. In this study, we report that two neurotrophin receptors (TrkA, TrkB) traverse divergent endocytic pathways...
Authors: Chen ZY, Ieraci A, Tanowitz M and Lee FS

Towards systematic identification of Plasmodium essential genes by transposon shuttle mutagenesis

After the deciphering of the genome sequences of several Plasmodium species, efforts must turn to elucidating gene function and identifying essential gene products. However, random approaches are lacking and gene targeting is inefficient in...
Authors: Sakamoto H, Thiberge S, Akerman S, Janse CJ, Carvalho TG and Menard R

Distinct enzyme combinations in AKAP signalling complexes permit functional diversity

Specificity in cell signalling can be influenced by the targeting of different enzyme combinations to substrates. The A-kinase anchoring protein AKAP79/150 is a multivalent scaffolding protein that coordinates the subcellular localization of...
Authors: Hoshi N, Langeberg LK and Scott JD

Immediate transfection of patient-derived leukemia: a novel source for generating cell-based vaccines

BACKGROUND: The production of cell-based cancer vaccines by gene vectors encoding proteins that stimulate the immune system has advanced rapidly in model systems. We sought to develop non-viral transfection methods that could transform patient tumor...
Authors: Gershan JA, Johnson BD, Weber J, Schauer DW, Natalia N, Behnke S, Burns K, Maloney KW, Warwick AB...

Genetic modification of hematopoietic stem cells with nonviral systems: past progress and future prospects

Serious unwanted complications provoked by retroviral gene transfer into hematopoietic stem cells (HSCs) have recently raised the need for the development and assessment of alternative gene transfer vectors. Within this context, nonviral gene...
Authors: Papapetrou EP, Zoumbos NC and Athanassiadou A