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Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax

Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. The HTLV-I transactivator protein Tax plays an integral role in the etiology of adult T cell...

Authors: Alefantis T, Barmak K, Harhaj E, Grant C and Wigdahl B

Forced expression of the Fc Receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation

High level expression of Fc epsilon RI gamma chain replaces the deficient TCR zeta-chain and contributes to altered TCR/CD3-mediated signaling abnormalities in T cells of patients with systemic lupus erythematosus. Increased responsiveness to Ag has...

Authors: Nambiar MP, Fisher CU, Kumar A, Tsokos CG, Warke VG and Tsokos GC

Characterization and analysis of the proximal Janus Kinase 3 promoter

Janus kinase 3 (Jak3) is a nonreceptor tyrosine kinase essential for signaling via cytokine receptors that comprise the common gamma-chain (gammac), i.e., the receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is preferentially expressed in...

Authors: Aringer M, Hofmann S, Frucht DM, Chen M, Centola M, Morinobu A, Visconti R, Kastner DL, Smolen JS...

ERK 1/2 and JNKs-dependent synthesis of IL-6 and IL-8 by fibroblast-like synoviocytes stimulated with protein I/II, a modulin from oral streptococci, requires FAK

Protein I/II, a pathogen-associated molecular pattern from oral streptococci, is a potent inducer of interleukin-6 (IL-6) and IL-8 synthesis and release from fibroblast-like synoviocytes (FLSs), cells that are critically involved in joint...

Authors: Neff L, Zeisel M, Druet V, Takeda K, Klein JP, Sibilia J and Wachsmann D

Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression

Binary complex formation between the immunosuppressive drug cyclosporin A (CsA) and cyclophilin 18 is the prerequisite for the ability of CsA to inhibit the protein phosphatase activity of calcineurin, a central mediator of antigen-receptor...

Authors: Baumgrass R, Zhang Y, Erdmann F, Thiel A, Weiwad M, Radbruch A and Fischer G

Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5

The p16INK4a-RB pathway plays a critical role in preventing inappropriate cell proliferation and is often targeted by viral oncoproteins during immortalization. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is often present in...

Authors: Ohtani N, Brennan P, Gaubatz S, Sanij E, Hertzog P, Wolvetang E, Ghysdael J, Rowe M and Hara E

Cathepsin D triggers Bax activation, resulting in selective AIF relocation in T lymphocytes entering the early commitment phase to apoptosis

Activated human T lymphocytes exposed to apoptotic stimuli targeting mitochondria (i.e. staurosporine), enter an early, caspase-independent phase of commitment to apoptosis characterized by cell shrinkage and peripheral chromatin condensation. We...

Authors: Bidère N, Lorenzo HK, Carmona S, Laforge M, Harper F, Dumont C and Senik A

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6

Mammalian cells express several transcription factors embedded in the endoplasmic reticulum (ER) as transmembrane proteins that are activated by proteolysis, and two types of these proteins have been extensively investigated. One type comprises the...

Authors: Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M and Mori K

The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer

Dendritic cells (DC), regarded as the most efficient APCs of the immune system, are capable of activating naive T cells. Thus, DC are primary targets in immunotherapy. However, little is known about gene regulation in DC, and for efficient...

Authors: Bros M, Ross XL, Pautz A, Reske-Kunz AB and Ross R

Inhibition of constitutive NF-kappaB activation in mantle cell lymphoma B cell lead to induction of cell cycle arrest and apoptosis

Constitutive activation of the NF-kappaB has been documented to be involved in the pathogenesis of many human malignancies, including hemopoietic neoplasms. In this study, we examined the status of NF-kappaB in two non-Hodgkin's lymphoma cell lines...

Authors: Pham LV, Tamayo AT, Yoshimura LC, Lo P and Ford RJ

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