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Downregulation of TGFbeta isoforms and their receptors contributes to keratinocyte hyperproliferation in psoriasis vulgaris

BACKGROUND: Psoriasis vulgaris is a chronic inflammatory disorder characterized by epidermal hyperproliferation. Transforming growth factor beta (TGFbetas) have a major antiproliferative action in epidermis. OBJECTIVE: We evaluated the distribution...

Authors: Doi H, Shibata MA, Kiyokane K and Otsuki Y

Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors

Daily alphavbeta5 integrin-dependent phagocytosis of spent photoreceptor outer segment fragments by the retinal pigment epithelium (RPE) is critical for retinal function. This study identifies a key role for focal adhesion kinase (FAK) in RPE...

Authors: Finnemann SC

Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCRzeta chain

Chimeric receptors that include CD28 signaling in series with TCRzeta in the same receptor have been demonstrated to activate prestimulated human primary T cells more efficiently than a receptor providing TCRzeta signaling alone. We examined whether...

Authors: Finney HM, Akbar AN and Lawson ADG

Apolopoprotein E binding to low density lipoprotein receptor related protein-1 inhibits cell migration via activation of cyclic 3',5'-adenosine monophosphate-dependend protein kinase A

Smooth muscle cell migration and proliferation contribute to neointimal hyperplasia and vascular stenosis after endothelial denudation. Previous studies revealed that apolipoprotein E (apoE) is an effective inhibitor of platelet-derived growth...

Authors: Zhu Y and Hui DY

Involvement of Crm 1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles

Hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer cells, we examined the effect of HBx on...

Authors: Forgues M, Difilippantonio MJ, Linke SP, Ried T, Nagashima K, Feden, J, Valerie K, Fukasawa K and...

A tetraspanin-family protein, T-cell acute lymphoblastic leukemia-associated antigen 1, is induced by the Ewing's Sarcoma-Wilms' tumor 1 fusion protein of desmoplastic small round-cell tumor

Recurrent chromosomal translocations in neoplasms often generate hybrid genes that play critical roles in tumorigenesis. Desmoplastic small round-cell tumor (DSRCT) is an aggressive malignancy associated with the chromosomal translocation...

Authors: Ito E, Honma R, Imai J, Azuma S, Kanno T, Mori S, Yoshie O, Nisho J, Iwasaki H, Yoshida K, Gohda J,...

Novel cell specific and dominant negative anti apoptotic roles of p73 in transformed leukemia cells

Although extensive homology exists between related genes p53 and p73, recent data suggest that the family members have divergent roles. We demonstrate that the differential regulatory roles of p53 family member p73 are highly cell-context and...

Authors: Freebern W, Smith JL, Chaudhry SS, Haggerty CM and Gardner K

A Salmonella protein causes macrophage cell death by inducing autophagy

Salmonella enterica, the causative agent of food poisoning and typhoid fever, induces programmed cell death in macrophages, a process found to be dependent on a type III protein secretion system, and SipB, a protein with membrane fusion activity that...

Authors: Hernandez LD, Pypaert M, Flavell RA and Galan JE

NPC1 and NPC2 regulate cholesterol homeostasis through generation of LDL cholesterol-derived oxysterols

Mutations in the Niemann-Pick disease genes cause lysosomal cholesterol accumulation and impaired low density lipoprotein (LDL) cholesterol esterification. These findings have been attributed to a block in cholesterol movement from lysosomes to the...

Authors: Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE and Ory DS

LPP, a LIM protein highly expressed in smooth muscle

An 80-kDa protein, prominently expressed in smooth muscle, was microsequenced and identified as LPP, the product of the lipoma-preferred partner gene (Petit MMR, Mols R, Schoenmakers EFPM, Mandahl N, and Van de Ven WJM. Genomics 36: 118-129, 1996)....

Authors: Gorenne I, Nakamoto RK, Phelps CP, Beckerle MC, Somlyo AV and Somlyo AP

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