Search Results

Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in vitro study.

Doxorubicin (Dox) is one of the most widely used antitumor drugs, but its cumulative cardiotoxicity have been major concerns in cancer therapeutic practice for decades. Recent studies established that metformin (Met), an oral anti-diabetic drug,...

Authors: Kobashigawa LC, Xu YC, Padbury JF, Tseng YT, Yano N.

SST Peer Reviewed

Function of chemokine (CXC motif) ligand 12 in periodontal ligament fibroblasts

The periodontal ligament (PDL) is one of the connective tissues located between the tooth and bone. It is characterized by rapid turnover. Periodontal ligament fibroblasts (PDLFs) play major roles in the rapid turnover of the PDL. Microarray analysis...

Authors: Yashiro Y, Nomura Y, Kanazashi M, Noda K, Hanada N, Nakamura Y

TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma.

Hyaluronan (HA) deposition is often correlated with mucosal inflammatory responses, where HA mediates both protective and pathological responses. By modifying the HA matrix, Tnfip6 (TNF-a-induced protein-6; also known as TSG-6 (TNF-stimulated...

Authors: Swaidani S1, Cheng G, Lauer ME, Sharma M, Mikecz K, Hascall VC, Aronica MA.

Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.

T helper 1 (Th1) cells have critical roles in various autoimmune and proinflammatory diseases. cAMP has long been believed to act as a suppressor of IFN-? production and Th1 cell-mediated immune inflammation. Here we show that cAMP actively promotes...

Authors: Yao C1, Hirata T, Soontrapa K, Ma X, Takemori H, Narumiya S.

SST Peer Reviewed

Neutrophil expression of Fas ligand and perforin directs effector CD8 T cell infiltration into antigen-challenged skin.

Contact hypersensitivity (CHS) is a T cell response to hapten skin challenge of sensitized individuals proposed to be mediated by hapten-primed CD8 cytolytic T cells. Effector CD8 T cell recruitment into hapten challenge sites to elicit CHS requires...

Authors: Kish DD1, Gorbachev AV, Parameswaran N, Gupta N, Fairchild RL.

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

RNA-guided endonucleases (RGENs), derived from the prokaryotic adaptive immune system known as CRISPR/Cas, enable targeted genome engineering in cells and organisms. RGENs are ribonucleoproteins that consist of guide RNA and Cas9, a protein component...

Authors: Cho SW, Kim S, Kim Y, Kweon J, Kim HS, Bae S, Kim JS

Neurotoxicity and mode of action of N, N-diethyl-meta-toluamide (DEET).

Recent studies suggest that N, N-diethyl-meta-toluamide (DEET) is an acetylcholinesterase inhibitor and that this action may result in neurotoxicity and pose a risk to humans from its use as an insect repellent. We investigated the mode of action of...

Authors: Swale DR, Sun B, Tong F, Bloomquist JR.

SST Peer Reviewed

Specific growth suppression of human cancer cells by targeted delivery of Dictyostelium mitochondrial ribosomal protein S4

BACKGROUND: In general, growth and differentiation are mutually exclusive but are cooperatively regulated throughout development. Thus, the process of a cell's switching from growth to differentiation is of great importance not only for the...

Authors: Chida J, Araki H, Maeda Y

Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.

Deficiency in C1q, the recognition component of the classical complement cascade and a pattern recognition receptor involved in apoptotic cell clearance, leads to lupus-like autoimmune diseases characterized by auto-antibodies to self proteins and...

Authors: Benoit ME1, Clarke EV, Morgado P, Fraser DA, Tenner AJ.

MicroRNA-mediated multi-tissue detargeting of oncolytic measles virus.

Precise oncotropism is required for successful systemic administration of next-generation oncolytic measles viruses (MVs). We have previously established a system for efficient post-entry targeting by insertion of synthetic microRNA target sites...

Authors: Baertsch M1, Leber MF, Bossow S, Singh M, Engeland CE, Albert J, Grossardt C, Jäger D, von Kalle C,...

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Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in vitro study.

Function of chemokine (CXC motif) ligand 12 in periodontal ligament fibroblasts

TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma.

Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.

Neutrophil expression of Fas ligand and perforin directs effector CD8 T cell infiltration into antigen-challenged skin.

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

Neurotoxicity and mode of action of N, N-diethyl-meta-toluamide (DEET).

Specific growth suppression of human cancer cells by targeted delivery of Dictyostelium mitochondrial ribosomal protein S4

Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.

MicroRNA-mediated multi-tissue detargeting of oncolytic measles virus.