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Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta

In vivo, left ventricular remodeling after myocardial infarction involves hypertrophy generally attributed to increased cardiac workload. We hypothesized that hypoxia/reoxygenation directly induces cardiomyocyte hypertrophy and studied several...

Authors: El Jamali A, Freund C, Rechner C, Scheidereit C, Dietz R and Bergmann MW

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

The Akt kinases promote hematopoietic cell growth and accumulation through phosphorylation of apoptotic effectors and stimulation of mTOR-dependent translation. In Akt-transformed leukemic cells, tumor growth can be inhibited by the mTOR inhibitor...

Authors: Hammerman PS, Fox CJ, Birnbaum MJ and Thompson CB

Nicotine Activates Nuclear Factor of Activated T Cells c2 (NFATc2) and Prevents Cell Cycle Entry in T Cells

We used primary peripheral blood T cells, a population that exists in G(0) and can be stimulated to enter the cell cycle synchronously, to define more precisely the effects of nicotine on pathways that control cell cycle entry and progression. Our...

Authors: Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ,...

Role of Chk1 and Chk2 in Ara-C-induced differentiation of human leukemia K562 cells

Human chronic myelogenous leukemia K562 cells are relatively resistant to the anti-metabolite cytosine arabinoside (Ara-C) and, when treated with Ara-C, they differentiate into erythrocytes without undergoing apoptosis. In this study we investigated...

Authors: Takagaki K, Katsuma S, Kaminishi Y, Horio T, Tanaka T, Ohgi T and Yano J

Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways

Norepinephrine released by the sympathetic nerve terminals regulates the immune system primarily via its stimulation of beta(2)-adrenergic receptor (beta(2)AR), but the underlying molecular mechanisms remain to be elicited. Beta(2)AR, a well-studied...

Authors: Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B and Pei G

RNAi-mediated silencing of X11alpha and X11beta attenuate Abeta levels via differential effects on APP processing

Processing of the beta-amyloid precursor protein (APP) plays a key role in Alzheimer's disease (AD) neuropathogenesis. APP is cleaved by beta-secretase and alpha-secretase to produce APP-C99 and APP-C83, which are further cleaved by gamma-secretase...

Authors: Xie Z, Romano DM and Tanzi RE

Mechanism of prostaglandin (PG)E2-induced prolactin expression in human T cells: cooperation of two PGE2 receptor subtypes, E-prostanoid (EP) 3 and EP4, via calcium- and cyclic adenosine 5'-monophosphate-mediated signaling pathways

We previously reported that prolactin gene expression in the T-leukemic cell line Jurkat is stimulated by PGE(2) and that cAMP acts synergistically with Ca(2+) or protein kinase C on the activation of the upstream prolactin promoter. Using the...

Authors: Gerlo S, Verdood P, Gellersen B, Hooghe-Peters EL and Kooijman R

Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo

Hic-5 is a focal adhesion protein belonging to the paxillin LIM family that shuttles in and out of the nucleus. In the present study, we examined the expression of Hic-5 among mouse tissues by immunohistochemistry and found its expression only in...

Authors: Kim-Kaneyama JR, Suzuki W, Ichikawa K, Ohki T, Kohno Y, Sata M, Nose K and Shibanuma M

Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by 1 integrins

The anti-angiogenic effect of thrombospondin-1 has been shown to be mediated through binding of the type-1 repeat (TSR) domain to the CD36 transmembrane receptor. We now report that the TSR domain can inhibit VEGF-induced migration in human umbilical...

Authors: Short SM, Derrien A, Narsimhan RP, Lawler J, Ingber DE and Zetter BR

Disruption of MCL-1/BIM complex in granzyme B-mediated mitochondrial apoptosis

Recently, we reported the identification of a novel mitochondrial apoptotic pathway for granzyme B (GrB) (JBC, 279:20020, 2004). The newly identified GrB-mediated mitochondrial cascade was initiated by the cleavage and subsequent degradation of...

Authors: Han J, Goldstein LA, Gastman BR, Rabinovitz A and Rabinowich H

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