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Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes.

Human interferon (IFN)-alpha is the standard therapy for chronic hepatitis C to prevent its progression to liver cirrhosis and hepatocellular carcinoma. Thrombocytopenia is one of the major adverse effects of IFN-alpha and often leads to dose...
Authors: Yamane A, Nakamura T, Suzuki H, Ito M, Ohnishi Y, Ikeda Y, Miyakawa Y.
SST Peer Reviewed

Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets

BACKGROUND: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate target gene dosage with...
Authors: Micklem DR, Blø M, Bergström P, Hodneland E, Tiron C, Høiby T, Gjerdrum C, Hammarsten O, Lorens JB

Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer

An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5' to the cystic fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell lines and primary human tracheal epithelial cells but is absent from...
Authors: Zhang Z, Leir SH, Harris A

Structure and biomechanics of the endothelial transcellular circumferential invasion array in tumor invasion

Cancer cells breach the endothelium not only through cell-cell junctions but also via individual endothelial cells (ECs), or transcellular invasion. The underlying EC forms a circular structure around the transcellular invasion pore that is dependent...
Authors: Arvanitis C, Khuon S, Spann R, Ridge KM, Chew TL

Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities.

BACKGROUND AND OBJECTIVES: Intracellular signaling initiated via Flt3 seems important in both leukemogenesis and chemosensitivity in acute myelogenous leukemia (AML). Flt3 is activated by binding of its natural Flt3-ligand (Flt3-L), but Flt3...
Authors: Bruserud Ø, Hovland R, Wergeland L, Huang TS, Gjertsen BT.
SST Peer Reviewed

Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial a5 integrin

Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through the bloodstream, arrest within capillaries, and extravasation to invade distant tissues. Few mechanistic details have been reported thus far regarding...
Authors: Cao Y, Hoeppner LH, Bach S, E G, Guo Y, Wang E, Wu J, Cowley MJ, Chang DK, Waddell N, Grimmond SM,...

Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium

Influenza viruses do not encode any proteases and must rely on host proteases for the proteolytic activation of their surface hemagglutinin proteins in order to fuse with the infected host cells. Recent progress in the understanding of human...
Authors: Beaulieu A, Gravel É, Cloutier A, Marois I, Colombo É, Désilets A, Verreault C, Leduc R, Marsault É,...

Arkadia regulates tumor metastasis by modulation of the TGF-ß pathway

TGF-ß can act as a tumor suppressor at early stages of cancer progression and as a tumor promoter at later stages. The E3 ubiquitin ligase Arkadia (RNF111) is a critical component of the TGF-ß signaling pathway, being required for a subset of...
Authors: Briones-Orta MA, Levy L, Madsen CD, Das D, Erker Y, Sahai E, Hill CS

Metabolic characterization of cell systems used in in vitro toxicology testing: lung cell system BEAS-2B as a working example

The bioactivation of pro-toxicants is the biological process through which some chemicals are metabolized into reactive metabolites. Therefore, in vitro toxicological evaluation should ideally be conducted in cell systems retaining adequate metabolic...
Authors: Garcia-Canton C, Minet E, Anadon A, Meredith C

Discovering aptamers by cell-SELEX against human soluble growth factors ectopically expressed on yeast cell surface

SELEX, the process of selecting aptamers, is often hampered by the difficulty of preparing target molecules in their native forms and by a lack of a simple yet quantitative assay for monitoring enrichment and affinity of reactive aptamers. In this...
Authors: Meng HW, Pagano JM, White BS, Toyoda Y, Min IM, Craighead HG, Shalloway D, Lis JT, Xiao K, Jin MM
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