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Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans.

OBJECTIVE: To determine the interleukin (IL)-6 levels in gingival crevicular fluid (GCF) of patients with severe root resorption after orthodontic treatment and investigate the effects of different static compressive forces (CFs) on IL-6...
Authors: Kunii R, Yamaguchi M, Tanimoto Y, Asano M, Yamada K, Goseki T, Kasai K.
SST Peer Reviewed

Comparison of ectopic gene expression methods in rat neural stem cells.

Neural stem cells (NSCs) have the ability to proliferate and differentiate into various types of cells that compose the nervous system. To study functions of genes in stem cell biology, genes or siRNAs need to be transfected. However, it is difficult...
Authors: Kim W, Kim JH, Kong SY, Park MH, Sohn UD, Kim HJ.
SST Peer Reviewed

A-type cranberry proanthocyanidins inhibit the RANKL-dependent differentiation and function of human osteoclasts.

This study investigated the effect of A-type cranberry proanthocyanidins (AC-PACs) on osteoclast formation and bone resorption activity. The differentiation of human pre-osteoclastic cells was assessed by tartrate-resistant acid phosphatase (TRAP)...
Authors: Tanabe S, Santos J, La VD, Howell AB, Grenier D.
SST Peer Reviewed

Generation of Human Induced Pluripotent Stem Cells Using Epigenetic Regulators Reveals a Germ Cell-Like Identity in Partially Reprogrammed Colonies

Previous studies have shown that induced pluripotent stem cells (iPSCs) can be derived from fibroblasts by ectopic expression of four transcription factors, OCT4, SOX2, KLF4 and c-MYC using various methods. More recent studies have focused on...
Authors: Goyal A, Chavez SL, Reijo Pera RA.
SST Peer Reviewed

Genome-wide copy number profiling to detect gene amplifications in neural progenitor cells

DNA sequence amplification occurs at defined stages during normal development in amphibians and flies and seems to be restricted in humans to drug-resistant and tumor cells only. We used array-CGH to discover copy number changes including gene...
Authors: Fischera U, Kellerb A, Backesb C, Meesea E
SST Peer Reviewed

A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation

Authors: Tomaru Y, Hasegawa R, Suzuki T, Sato T, Kubosaki A, Suzuki M, Kawaji H, Forrest AR, Hayashizaki Y;...

EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo.

Salivary adenoid cystic carcinoma (SACC) is a frequent subtype of salivary gland malignancy, and it has an important biological behavior for perineural invasion (PNI). Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane...
Authors: Yang X, Zhang P, Ma Q, Kong L, Li Y, Liu B, Lei D.
SST Peer Reviewed

A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance

Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth, metastasis, and drug resistance of cancer cells. The current clinically established RNR inhibitors have the shortcomings...
Authors: Zhou B, Su L, Hu S, Hu W, Yip ML, Wu J, Gaur S, Smith DL, Yuan YC, Synold TW, Horne D, Yen Y

Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk

Autism spectrum disorder (ASD) is a highly heritable, behaviorally defined, heterogeneous disorder of unknown pathogenesis. Several genetic risk genes have been identified, including the gene encoding the receptor tyrosine kinase MET, which regulates...
Authors: Mukamel Z, Konopka G, Wexler E, Osborn GE, Dong H, Bergman MY, Levitt P, Geschwind DH.
SST Peer Reviewed

High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling

Fibroblast growth factor 2 (FGF-2) is a multifunctional protein synthesized as high (Hi-) and low (Lo-) molecular weight isoforms. Studies using rodent models showed that Hi- and Lo-FGF-2 exert distinct biological activities: after myocardial...
Authors: Santiago JJ, McNaughton LJ, Koleini N1, Ma X, Bestvater B, Nickel BE, Fandrich RR, Wigle JT, Freed...