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4923 results sorted by

Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s)

Calsenilin/potassium channel-interacting protein (KChIP)3/ downstream regulatory element sequence antagonist modulator (DREAM) is a neuronal calcium-binding protein that has been shown to have multiple functions in the cell, including the regulation...
Authors: Zaidi NF, Kuplast KG, Washicosky KJ, Kajiwara Y, Buxbaum JD, Wasco W

Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis

In the intrinsic pathway of apoptosis, mitochondria play a crucial role by releasing cytochrome c from the inter-membrane space into the cytoplasm. Cytochrome c release through Bax/Bak-dependent channels in mitochondria has been well-documented. In...
Authors: Yasuda O, Fukuo K, Sun X, Nishitani M, Yotsui T, Higuchi M, Suzuki T, Rakugi H, Smithies O, Maeda N,...

Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation

Interference of measles virus (MV) with phosphatidyl-inositol-3-kinase (PI3K) activation in response to T cell receptor ligation was identified as important for the induction of T cell paralysis. We now show that MV exposure of unstimulated T cells...
Authors: Avota E, Harms H, Schneider-Schaulies S

The HTLV-I p30 Interferes with TLR4 signaling and modulates the release of pro-and anti-inflammatory cytokines from human macrophages

While adaptive immunity has been extensively studied, very little is known about host's innate immunity to HTLV-I infection. HTLV-I infected ATL patients have pronounced immunodeficiency associated with frequent opportunistic infections and in these...
Authors: Datta A, Sinha-Datta U, Kaur Dhillon N, Buch S, Nicot C

Fine Mapping of Genetic Susceptibility to Polycystic Ovary Syndrome on Chromosome 19p13.2 and Tests for Regulatory Activity

Context: Little is known about genes that contribute to polycystic ovary syndrome (PCOS). We previously found linkage and association of PCOS with the dinucleotide marker D19S884 in two independent sets of families; allele 8 of D19S884 confers...
Authors: Stewart DR, Dombroski B, Urbanek M, Ankener W, Ewens KG, Wood JR, Legro RS, Strauss JF 3rd, Dunaif...

PPARgamma regulated ABCG2 expression confers cytoprotection to human dendritic cells

ABCG2, a member of the ATP-Binding Cassette transporters has been identified as a protective pump against endogenous and exogenous toxic agents. ABCG2 was shown to be expressed at high levels in stem cells, and variably regulated during cell...
Authors: Szatmari I, Vamosi G, Brazda P, Balint BL, Benko S, Szeles L, Jeney V, Ozvegy-Laczka C, Szanto A,...

A Single Common Portal for Clathrin-mediated Endocytosis of Distinct Cargo Governed by Cargo-selective Adaptors

Sorting of transmembrane cargo into clathrin-coated vesicles requires endocytic adaptors, yet RNA interference (RNAi)-mediated gene silencing of the AP-2 adaptor complex only disrupts internalization of a subset of clathrin-dependent cargo. This...
Authors: Keyel PA, Mishra SK, Roth R, Heuser JE, Watkins SC, Traub LM

Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms

Melanin synthesized by epidermal melanocytes protects the skin against UVR-induced DNA damage and skin cancer. Exposure to UVR increases the synthesis of the photoprotective eumelanin on activation of MC1R, a melanoma susceptibility gene. We studied...
Authors: Rouzaud F, Costin GE, Yamaguchi Y, Valencia JC, Berens WF, Chen KG, Hoashi T, Bohm M, Abdel-Malek...

Phosphatidylinositol-3-Kinase Regulates Scavenger Receptor Class B Type I Subcellular Localization and Selective Lipid Uptake in Hepatocytes

OBJECTIVE: The high-density lipoprotein (HDL) receptor scavenger receptor Class B type I (SR-BI) plays a key role in mediating the final step of reverse cholesterol transport. This study examined the possible regulation of hepatic SR-BI by...
Authors: Shetty S, Eckhardt ER, Post SR, van der Westhuyzen DR

Molecular network and chromosomal clustering of genes involved in synaptic plasticity in the hippocampus

Gene transcription is required for establishing and maintaining the enduring form of long term potentiation (LTP). However, the transcriptome and its associated molecular programs that support LTP are not well understood. The purpose of this study...
Authors: Park CS, Gong R, Stuart J, Tang SJ
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