Search Results

Target proteins of C/EBPp30 in AML: C/EBPp30 enhances sumoylation of C/EBPp42 via up-regulation of Ubc9

CCAAT/enhancer-binding protein alpha (C/EBPalpha) is a critical regulator for early myeloid differentiation. Mutations in C/EBPalpha occur in 10% of AML patients, leading to the expression of a 30kDa dominant negative isoform (C/EBPalphap30). In the...

Authors: Geletu M, Balkhi MY, Peer Zada AA, Christopeit M, Anto Pulikkan J, Kumar Trivedi A, Tenen DG, Behre...

SST Peer Reviewed

CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling

In mammals, beta1 integrin adhesion receptors generate signals that mediate cell spreading, migration, proliferation, and survival. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin beta subunit cytoplasmic...

Authors: Prager GW, Feral CC, Kim C, Han J, Ginsberg MH

Commitment to apoptosis in CD4(+) T lymphocytes productively infected with human immunodeficiency virus type 1 is initiated by lysosomal membrane permeabilization, itself induced by the isolated expression of the viral protein Nef

Primary CD4(+) T lymphocytes, supporting in vitro human immunodeficiency virus type 1 (HIV-1) replication, are destined to die by apoptosis. We explored the initial molecular events that act upstream from mitochondrial dysfunction in CD4(+) T...

Authors: Laforge M, Petit F, Estaquier J, Senik A

SST Peer Reviewed

Foxo3 is required for the regulation of oxidative stress in erythropoiesis

Erythroid cells accumulate hemoglobin as they mature and as a result are highly prone to oxidative damage. However, mechanisms of transcriptional control of antioxidant defense in erythroid cells have thus far been poorly characterized. We observed...

Authors: Marinkovic D, Zhang X, Yalcin S, Luciano JP, Brugnara C, Huber T, Ghaffari S

Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras

Notch is a central regulator of important cell fate decisions. Notch activation produces diverse cellular effects suggesting the presence of context-dependent control mechanisms. Genetic studies have demonstrated that Notch and integrin mutations...

Authors: Hodkinson PS, Elliot PA, Lad Y, McHugh BJ, Mackinnon AC, Haslett C, Sethi T

Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation

PURPOSE: Interactions between the multikinase inhibitor sorafenib (Bay 43-9006) and the histone deacetylase inhibitor vorinostat were examined in chronic myelogenous leukemia (CML) cells sensitive and resistant to imatinib mesylate. EXPERIMENTAL...

Authors: Dasmahapatra G, Yerram N, Dai Y, Dent P, Grant S

The neuronal Arf GAP centaurin 1 modulates dendritic differentiation

Centaurin alpha1 is an Arf GTPase-activating protein (GAP) that is highly expressed in the nervous system. In the current study, we show that endogenous centaurin alpha1 protein is localized in the synaptosome fraction, with peak expression in early...

Authors: Moore CD, Thacker EE, Larimore J, Gaston D, Underwood A, Kearns B, Patterson SI, Jackson T, Chapleau...

SST Peer Reviewed

Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) in activated B lymphocytes and is potentially implicated in genomic instability of B-cell malignancies. For unknown reasons, B-cell...

Authors: Popov SW, Moldenhauer G, Wotschke B, Brüderlein S, Barth TF, Dorsch K, Ritz O, Möller P, Leithäuser...

Epigenetic regulation of tumor necrosis factor alpha

Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message...

Authors: Sullivan KE, Reddy AB, Dietzmann K, Suriano AR, Kocieda VP, Stewart M, Bhatia M

Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer

Cancer cells become metastatic by acquiring a motile and invasive phenotype. This step requires remodeling of the actin cytoskeleton and the expression of exploratory, sensory organelles known as filopodia. Aberrant beta-catenin-TCF target gene...

Authors: Vignjevic D, Schoumacher M, Gavert N, Janssen KP, Jih G, Laé M, Louvard D, Ben-Ze'ev A, Robine S

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Target proteins of C/EBPp30 in AML: C/EBPp30 enhances sumoylation of C/EBPp42 via up-regulation of Ubc9

CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling

Commitment to apoptosis in CD4(+) T lymphocytes productively infected with human immunodeficiency virus type 1 is initiated by lysosomal membrane permeabilization, itself induced by the isolated expression of the viral protein Nef

Foxo3 is required for the regulation of oxidative stress in erythropoiesis

Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras

Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation

The neuronal Arf GAP centaurin 1 modulates dendritic differentiation

Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma

Epigenetic regulation of tumor necrosis factor alpha

Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer