Search Results

The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib

Multiple myeloma (MM) is an incurable plasma cell malignancy. The recent successes of the proteasome inhibitor bortezomib in MM therapy have prompted investigations of its efficacy in combination with other anticancer agents. Polyamines play...

Authors: Carew JS, Nawrocki ST, Reddy VK, Bush D, Rehg JE, Goodwin A, Houghton JA, Casero RA Jr, Marton LJ,...

Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL

BACKGROUND: One of the important biological activities of thrombopoietin (TPO) is to prevent the apoptosis of megakaryocytes. As the antiapoptotic protein Bcl-xL, which has been proven to be indispensable for erythroid differentiation, is also...

Authors: Kozuma Y, Kojima H, Yuki S, Suzuki H, Nagasawa T

In vitro restoration of functional SMN protein in human trophoblast cells affected by spinal muscular atrophy by small fragment homologous replacement

The majority of patients affected by spinal muscular atrophy (SMA) have deletion of the survival of motor neuron 1 (SMN1) gene, but they retain a "nonfunctional" copy of the duplicate gene (SMN2) in their genome. SMN2 produces defective SMN protein...

Authors: Sangiuolo F, Filareto A, Spitalieri P, Scaldaferri ML, Mango R, Bruscia E, Citro G, Brunetti E, De...

SST Peer Reviewed

IL-3 induced c-Fos activation is modulated by Gab2-calcineurin interaction

IL-3 regulates cell growth by affecting various processes such as cell death, survival and proliferation. Cues from the external environment are sensed by surface receptors, and complex signaling mechanisms within the cells lead to specific...

Authors: Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ

Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells

Killer Ig-like receptor (KIR) expression is mostly restricted to NK cells controlling their activation. With increasing age, KIRs are expressed on T cells and contribute to age-related diseases. We examined epigenetic mechanisms that determine the...

Authors: Li G, Weyand CM, Goronzy JJ

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

MicroRNAs (miRNAs) are noncoding RNAs that base pair imperfectly to homologous regions in target mRNAs and negatively influence the synthesis of the corresponding proteins. Repression is mediated by a number of mechanisms, one of which is the direct...

Authors: Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M,...

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

Diabetic patients continue to develop inflammation and vascular complications even after achieving glycemic control. This poorly understood "metabolic memory" phenomenon poses major challenges in treating diabetes. Recent studies demonstrate a link...

Authors: Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R

RSV-induces RelA release from cytoplasmic 100 kDa NF-kappa B2 complexes via a novel retinoic acid inducible gene-I-NF-kappa B inducing kinase (NIK) signaling pathway

Respiratory Syncytial Virus (RSV) is a primary cause of severe lower respiratory tract infection in children worldwide. RSV infects airway epithelial cells, where it activates inflammatory genes via the NF-B pathway. NF-B is controlled by two...

Authors: Liu P, Li K, Garofalo RP, Brasier AR

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor, A443654, in T-Acute Lymphoblastic Leukemia

Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the novel AKT inhibitor, A443654, leads to rapid cell death of T-ALL lines and patient samples. Treatment of CEM, Jurkat, and...

Authors: Fala F, Blalock WL, Tazzari P, Cappellini A, Chiarini F, Martinelli G, Tafuri A, McCubrey JA, Cocco...

PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmomtic stress in airway epithelial cells

Airway epithelial Na-K-2Cl (NKCC1) cotransport is activated through hormonal stimulation and hyperosmotic stress via a PKCdelta-mediated intracellular signalling pathway. Downregulation of PKCdeltaprevents activation of NKCC1 expressed in Calu-3...

Authors: Smith L, Smallwood N, Altman A, Liedtke CM

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