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Hepatocyte Culture Medium

HCM is  a serum-free medium for maintenance of cultures prior to and during experimental procedures.It is the preferred medium when working with cryopreserved human and animal hepatocytes.

Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions

Despite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor microenvironment, which is characterized by the abundance of cancer-associated fibroblasts...
Authors: Boelaars K, Rodriguez E, Huinen ZR, Liu C, Wang D, Springer BO, Olesek K, Goossens-Kruijssen L, van...
SST Peer Reviewed

Hepatocyte Maintenance Medium

HMM is a serum-free medium that may be used to maintain fresh plated human and animal hepatocytes in culture during testing.

Protocol for optimizing culture conditions for ex vivo activation during CRISPR-Cas9 gene editing in human hematopoietic stem and progenitor cells

Long-range correction strategies require ex vivo activation of hematopoietic stem and progenitor cells (HSPCs) to engage the homology-directed repair (HDR) mechanism, but prolonged culture causes harmful cellular responses, reducing the long-term...
Authors: Della Volpe L, Vacca R, Di Micco R
SST Peer Reviewed

Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases

Cell-based ex vivo gene therapy in solid organs, especially the liver, has proven technically challenging. Here, we report a feasible strategy for the clinical application of hepatocyte therapy. We first generated high-quality autologous hepatocytes...
Authors: Kun Zhang , Ping Wan , Liren Wang , Zhen Wang , Fangzhi Tan , Jie Li , Xiaolong Ma , Jin Cen , Xiang...

A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells

Ex vivo activation is a prerequisite to reaching adequate levels of gene editing by homology-directed repair (HDR) for hematopoietic stem and progenitor cell (HSPC)-based clinical applications. Here, we show that shortening culture time mitigates the...
Authors: Della Volpe L, Midena F, Vacca R, Tavella T, Alessandrini L, Farina G, Brandas C, Lo Furno E,...
SST Peer Reviewed

Keratinocyte Growth Medium 2

KGM-2 has been discontinued. As alternative we recommend the KGM-Gold BulletKit 00192060Supports proliferation of primary human keratinocytes in culture.Drives faster proliferation than the original KGM.Now superceded by KGM-Gold

Keratinocyte Growth Medium 2, Calcium-free

A serum-free, calcium free keratinocyte growth medium

Keratinocyte Growth Medium Gold

Optimized for Normal Human Epidermal Keratinocytes in a serum-free environment.Provides a nutrient rich medium that provides normal physiological growth characteristics and population doubling times.KGM-Gold supports low, moderate, and high density...

Lymphocyte Growth Medium-3

LGM-3 is a serum-free medium for lymphocyte and dendritic cell growth
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