Search Results

Cytokine-Independent Upregulation of MDA5 in Viral Infection

The RNA helicases RIG-I and MDA5 detect virus infection of dendritic cells (DCs) leading to cytokine induction. Maximal sensitivity for virus detection by these helicases is obtained after their upregulation, which is thought to occur primarily...

Authors: Yount JS, Moran TM, Lopez CB

Histone Deacetylase Inhibitors Sensitize Prostate Cancer Cells to Agents that Produce DNA Double-Strand Breaks by Targeting Ku70 Acetylation

This study reports a histone deacetylation-independent mechanism whereby histone deacetylase (HDAC) inhibitors sensitize prostate cancer cells to DNA-damaging agents by targeting Ku70 acetylation. Ku70 represents a crucial component of the...

Authors: Chen CS, Wang YC, Yang HC, Huang PH, Kulp SK, Yang CC, Lu YS, Matsuyama S, Chen CY, Chen CS

The molecular mechanism of hepcidin-mediated ferroportin down-regulation

Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron or inflammation, binds to Fpn inducing its internalization and degradation. We show that after binding of hepcidin, Fpn is...

Authors: De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J

Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has emerged as a promising prognostic marker and putative therapeutic target in prostate cancer (PCa). However, the mechanisms of prostate-specific regulation and...

Authors: Bidaux G, Flourakis M, Thebault S, Zholos A, Beck B, Gkika D, Roudbaraki M, Bonnal JL, Mauroy B,...

The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition

BACKGROUND: Interleukin-6 and downstream liver effectors acute phase reactants are implicated in the systemic inflammatory reaction. Peroxisome proliferator-activated receptor delta (PPARdelta), which binds to and is activated by a variety of fatty...

Authors: Kino T, Rice KC, Chrousos GP

Novel c-CBL and CBL-B ubiquitin ligase mutations in human acute myeloid leukemia

The CBL ubiquitin ligase targets a variety of activated tyrosine kinases (TK) for degradation. Many TKs are mutationally or autocrine-activated and/or often over-expressed at the mRNA and protein levels in acute leukemias. We hypothesized that CBL is...

Authors: Caligiuri MA, Briesewitz R, Yu J, Wang L, Wei M, Arnoczky KJ, Marburger TB, Wen J, Perrotti D,...

Corticosteroid Inhibition of Growth-Related Oncogene Protein- via Mitogen-Activated Kinase Phosphatase-1 in Airway Smooth Muscle Cells

Expression of the inflammatory chemokine, growth-related oncogene protein-alpha (GRO-alpha), from airway smooth muscle cells (ASMC) is regulated by pathways involving NF-kappaB and MAPK activation. We determined the effects of dexamethasone on...

Authors: Issa R, Xie S, Khorasani N, Sukkar M, Adcock IM, Lee KY, Chung KF

Proteomic Analysis Identifies Oxidative Stress Induction by Adaphostin

PURPOSE: Activities distinct from inhibition of Bcr/abl have led to adaphostin (NSC 680410) being described as "a drug in search of a mechanism." In this study, proteomic analysis of adaphostin-treated myeloid leukemia cell lines was used to further...

Authors: Stockwin LH, Bumke MA, Yu SX, Webb SP, Collins JR, Hollingshead MG, Newton DL

Interaction of PRP4 with Kruppel-Like Factor 13 Regulates CCL5 Transcription

Activation of resting T lymphocytes initiates differentiation into mature effector cells over 3-7 days. The chemokine CCL5 (RANTES) and its major transcriptional regulator, Krüppel-like factor 13 (KLF13), are expressed late (3-5 days) after...

Authors: Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM

Gene expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt's lymphoma cell lines and primary tumors

Burkitt lymphoma (BL) is a B-cell tumor whose characteristic gene aberration is the translocation t(8;14), which determines c-myc overexpression. Several genetic and epigenetic alterations, other than c-myc overexpression, have also been described in...

Authors: De Falco G, Leucci E, Lenze D, Piccaluga PP, Claudio PP, Onnis A, Cerino G, Nyagol J, Mwanda W,...

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