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Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19)

Last decade witnessed the outbreak of many life-threatening human pathogens including Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS-CoV), Severe Acute respiratory...

Authors: Shanmugaraj B1,2, Siriwattananon K1,2, Wangkanont K3, Phoolcharoen W1,2.

SST Peer Reviewed

In vitro and in vivo evaluation of discogenic cells, an investigational cell therapy for disc degeneration

BACKGROUND/CONTEXT: Disc degeneration (DD) is a significant driver of low back painand few treatments exist to treat the pain and disability associated with the disease.PURPOSE: Our group has developed a method to generate therapeutic discogenic...

Authors: Lara Ionescu Silverman, Galina Dulatova,Terry Tandeski, Isaac E. Erickson, Beverly Lundell, David...

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.

Antigen-directed immunotherapies for acute myeloid leukemia (AML), such as chimeric antigen receptor T cells (CAR-Ts) or antibody-drug conjugates (ADCs), are associated with severe toxicities due to the lack of unique targetable antigens that can...

Authors: Borot F, Wang H, Ma Y, Jafarov T, Raza A, Ali AM, Mukherjee S.

SST Peer Reviewed

Sperm DNA damage causes genomic instability in early embryonic development

Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, weexamined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genomesequencing of individual blastomeres from bovine...

Authors: Sjors Middelkamp, Helena T. A. van Tol, Diana C. J. Spierings, Sander Boymans,Victor Guryev, Bernard...

a2-HS Glycoprotein in Plasma Extracellular Vesicles Inhibits the Osteogenic Differentiation of Human Mesenchymal Stromal Cells In Vitro

Extracellular vesicles (Evs) contain diverse functional proteins, mRNAs, miRNAs, and DNA fragments, are secreted by various types of cells, and play important roles in cellular communication. Here, we show for the first time that plasma Evs inhibited...

Authors: Xiaohua Wu , Mengjun Ma , Peng Wang , Zhongyu Xie , Shan Wang , Hongjun Su , Wen Deng , Pei...

CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes With Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner

Respiratory syncytial virus (RSV) is the principal cause of bronchiolitis in infants and a significant healthcare problem. The RSV Glycoprotein (G) mediates attachment of the virus to the cell membrane, which facilitates interaction of the RSV Fusion...

Authors: Kwang-Il Jeong 1 , Peter A Piepenhagen 2...

SST Peer Reviewed

Inhibition of Replication and Infection of Severe Acute Respiratory Syndrome-Associated Coronavirus With Plasmid-Mediated Interference RNA

Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease caused by a novel coronavirus (SARS-CoV), which spread to over 30 countries in early 2003. Until recently, no specific vaccines and effective drugs have been available to...

Authors: Bing Ni 1 , Xinfu Shi, Yang Li, Wenda Gao, Xiliang Wang, Yuzhang Wu

SST Peer Reviewed

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Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19)

In vitro and in vivo evaluation of discogenic cells, an investigational cell therapy for disc degeneration

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.

Sperm DNA damage causes genomic instability in early embryonic development

a2-HS Glycoprotein in Plasma Extracellular Vesicles Inhibits the Osteogenic Differentiation of Human Mesenchymal Stromal Cells In Vitro

CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes With Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner

Inhibition of Replication and Infection of Severe Acute Respiratory Syndrome-Associated Coronavirus With Plasmid-Mediated Interference RNA

Decoy exosomes as a novel biologic reagent to antagonize inflammation

IRF2 is a master regulator of human keratinocyte stem cell fate

Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome