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Mincle Activation and the Syk/Card9 Signaling Axis are Central to the Development of the Autoimmune Disease of the Eye

Uveitis, which occurs in association with systemic immunological diseases, presents a considerable medical challenge because of incomplete understanding of its pathogenesis. The signals that initiate T cells to target the eye, which may be of...

Authors: Ellen J. Lee, Brieanna R. Brown, Emily E. Vance, Paige E. Snow, Phyllis B. Silver, David...

Development of glial restricted human neural stem cells for oligodendrocyte differentiation in vitro and in vivo.

In this study, we have developed highly expandable neural stem cells (NSCs) from HESCs and iPSCs that artificially express the oligodendrocyte (OL) specific transcription factor gene Zfp488. This is enough to restrict them to an exclusive...

Authors: Biswas S Chung SH Jiang P Dhaghan S Deng W

Proteoglycan-Induced Arthritis and Recombinant Human Proteoglycan Aggrecan G1 Domain–Induced Arthritis in BALB/c Mice Resembling Two Subtypes of Rheumatoid Arthritis

Objective. To develop a simplified and relatively inexpensive version of cartilage proteoglycan–induced arthritis (PGIA), an autoimmunity model of rheumatoid arthritis (RA), and to evaluate the extent to which this new model replicates the disease...

Authors: Tibor T. Glant, Marianna Radacs, Gyorgy Nagyeri, Katalin Olasz, Anna Laszlo, Ferenc Boldizsar, Akos...

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro.

BACKGROUND:Oligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS. Oligodendrocyte death and defects are the leading causes of several myelin disorders such...

Authors: Namchaiw P WEn H Mayrhofer F Chechneva O Biswas S Deng W

Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits neurofilament Light Chain (NF-L) Gene expression in Human Neuronal-Glial (HNG) Cells in Primary Culture

The remarkable co-localization of highly pro-inflammatory lipopolysaccharide (LPS) with sporadic Alzheimer's disease (AD)-affected neuronal nuclei suggests that there may be some novel pathogenic contribution of this heat stable neurotoxin...

Authors: Walker J. Lukiw, Lin Cong, Vivian Jaber, Yuhai Zhao

SST Peer Reviewed

Identification and Characterization of a TranscribedDistal Enhancer Involved in Cardiac Kcnh2Regulation

The human ether-a-go-go-related gene KCNH2encodes the voltage-gated potassium channelunderlying IKr, a current critical for the repolarizationphase of the cardiac action potential. Mutations inKCNH2 that cause a reduction of the repolarizingcurrent...

Authors: Malou van den Boogaard,Jan Hendrik van Weerd,Amira C. Bawazeer, ..., Phil Barnett,Jeroen Bakkers,...

Genome editing for human gene therapy.

The rapid advancement of genome-editing techniques holds much promise for the field of human gene therapy. From bacteria to model organisms and human cells, genome editing tools such as zinc-finger nucleases (ZNFs), TALENs, and CRISPR/Cas9 have been...

Authors: Meissner TB1, Mandal PK2, Ferreira LM1, Rossi DJ3, Cowan CA4.

SST Peer Reviewed

Hydrophilic titanium surface-induced macrophage modulation promotes pro-osteogenic signalling.

OBJECTIVES:As biomaterial-induced modulation of mediators of the immune response may be a potential therapeutic approach to enhance wound healing events, the aim of this study was to delineate the effects of titanium surface...

Authors: Hamlet SM Lee RSB Moon HJ Alfarsi MA Ivanovski S

POTENTIAL ROLE OF CULTURE MEDIUMS FOR SUCCESSFUL ISOLATION ANDNEURONAL DIFFERENTIATION OF AMNIOTIC FLUID STEM CELLS

In recent years, the use of stem cells has generated increasing interest in regenerative medicineand cancer therapies. The most potent stem cells derive from the inner cell mass during embryonicdevelopment and their use yields serious ethical and...

Authors: M. ORCIANI, M. EMANUELLII, C. MARTIN0, A. PUGNALONI,A.L. TRANQUILLI and R. DI PRIMIO

Translating intracarotid artery transplantation of bone marrow-derived NCS-01 cells for ischemic stroke: Behavioral and histological readouts and mechanistic insights into stem cell therapy.

The present study used in vitro and in vivo stroke models to demonstrate the safety, efficacy, and mechanism of action of adult human bone marrow-derived NCS-01 cells. Coculture with NCS-01 cells protected primary rat cortical cells or human neural...

Authors: Kaneko Y, Lee JY, Tajiri N, Tuazon JP, Lippert T, Russo E, Yu SJ, Bonsack B, Corey S, Coats...

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