Search Results

Type 1 diabetes immunotherapy using polyclonal regulatory T cells.

Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune disease setting. Thus, efforts to repair or replace Tregs in T1D may...

Authors: Bluestone JA1, Buckner JH2, Fitch M3, Gitelman SE4, Gupta S2, Hellerstein MK3, Herold KC5, Lares A6,...

SST Peer Reviewed

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.

Despite the development of combined modality treatments against liposarcoma in recent years, a significant proportion of patients respond only modestly to such approaches, possibly contributing to local or distant recurrence. Early detection of...

Authors: Casadei L1,2, Calore F3, Creighton CJ4, Guescini M5, Batte K1,2, Iwenofu OH6, Zewdu A1,2, Braggio...

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems

One of the greatest threats to humanity is the emergence of a pandemic virus. Among those with the greatest potential for such an event include influenza viruses and coronaviruses. In the last century alone, we have observed four major influenza A...

Authors: Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen-Chun Liu, Rasmus Møller, Maryline Panis, David...

SST Peer Reviewed

Surface display vectors for selective detection and isolation of high level antibody producing cells.

Cell line generation for production of biopharmaceuticals in mammalian cells usually involves intensive screening of clones to identify the rare high producers. In order to facilitate efficient and selective fluorescence activated cell sorting (FACS)...

Authors: Lang S1, Drewello D1, Wichter J2, Nommay A1, Wilms B1, Knopf HP1, Jostock T3.

SST Peer Reviewed

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression.

BACKGROUND:The function of preadipocytes in the progression of early stage breast cancer has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in breast cancer progression, we investigated the cross-talk between...

Authors: Kim HS, Jung M, Choi SK, Woo J, Piao YJ, Hwang EH, Kim H, Kim SJ, Moon WK.

Virological Assessment of Hospitalized Patients With COVID-2019

Coronavirus disease 2019 (COVID-19) is an acute respiratory tract infection that emerged in late 20191,2. Initial outbreaks in China involved 13.8% cases with severe, and 6.1% with critical courses3. This severe presentation corresponds to the usage...

Authors: Roman Wölfel 1 , Victor M Corman 2 , Wolfgang...

SST Peer Reviewed

Quantitative analysis of the CD4+ T cell response to therapeutic antibodies in healthy donors using a novel T cell:PBMC assay.

Many biopharmaceuticals (BPs) are known to be immunogenic in the clinic, which can result in modified pharmacokinetics, reduced efficacy, allergic reactions and anaphylaxis. During recent years, several technologies to predict immunogenicity have...

Authors: Schultz HS1, Reedtz-Runge SL2, Bäckström BT1, Lamberth K1, Pedersen CR3, Kvarnhammar AM1; ABIRISK...

SST Peer Reviewed

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy

Abstract There has been a resurgence in gene therapyefforts that is partly fueled by the identification andunderstanding of new gene delivery vectors. Adeno-associatedvirus (AAV) is a non-enveloped virus that can beengineered to deliver DNA to target...

Authors: Michael F. Naso, Brian Tomkowicz, William L. Perry III, William R. Strohl

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

Background:Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-inflammatory cytokines. Various phytochemicals have been reported to contribute to the beiging of white adipose tissue...

Authors: Samuels JS1, Shashidharamurthy R1, Rayalam S1

A p53-dependent response limits the viability of mammalian haploid cells.

The recent development of haploid cell lines has facilitated forward genetic screenings in mammalian cells. These lines include near-haploid human cell lines isolated from a patient with chronic myelogenous leukemia (KBM7 and HAP1), as well as...

Authors: Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gomez C, Ortega S, Ruiz S, Fernandez-Capetillo O.

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Topic

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Type 1 diabetes immunotherapy using polyclonal regulatory T cells.

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems

Surface display vectors for selective detection and isolation of high level antibody producing cells.

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression.

Virological Assessment of Hospitalized Patients With COVID-2019

Quantitative analysis of the CD4+ T cell response to therapeutic antibodies in healthy donors using a novel T cell:PBMC assay.

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

A p53-dependent response limits the viability of mammalian haploid cells.