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Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

COVID-19 is associated with lymphopenia and ‘cytokine storm’, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, wecharacterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory...

Authors: Daniela Weiskopf, Katharina S. Schmitz, Matthijs P. Raadsen, Alba Grifoni, Nisreen M.A. Okba, Henrik...

Dendritic cell MST1 inhibits Th17 differentiation.

Although the differentiation of CD4+T cells is widely studied, the mechanisms of antigen-presenting cell-dependent T-cell modulation are unclear. Here, we investigate the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and...

Authors: Li C, Bi Y, Li Y, Yang H, Yu Q, Wang J, Wang Y, Su H, Jia A, Hu Y, Han L, Zhang J, Li S, Tao W, Liu...

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.

Antigen-directed immunotherapies for acute myeloid leukemia (AML), such as chimeric antigen receptor T cells (CAR-Ts) or antibody-drug conjugates (ADCs), are associated with severe toxicities due to the lack of unique targetable antigens that can...

Authors: Borot F, Wang H, Ma Y, Jafarov T, Raza A, Ali AM, Mukherjee S.

SST Peer Reviewed

The Replication of a Mouse Adapted SARS-CoV in a Mouse Cell Line Stably Expressing the Murine SARS-CoV Receptor mACE2 Efficiently Induces the Expression of Proinflammatory Cytokines

Infection of conventional mice with a mouse adapted (MA15) severe acute respiratory syndrome (SARS) coronavirus (CoV) reproduces many aspects of human SARS such as pathological changes in lung, viremia, neutrophilia, and lethality. However,...

Authors: Jose A Regla-Nava 1 , Jose M Jimenez-Guardeño, Jose L Nieto-Torres, Thomas...

SST Peer Reviewed

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.

Despite the development of combined modality treatments against liposarcoma in recent years, a significant proportion of patients respond only modestly to such approaches, possibly contributing to local or distant recurrence. Early detection of...

Authors: Casadei L1,2, Calore F3, Creighton CJ4, Guescini M5, Batte K1,2, Iwenofu OH6, Zewdu A1,2, Braggio...

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression.

BACKGROUND:The function of preadipocytes in the progression of early stage breast cancer has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in breast cancer progression, we investigated the cross-talk between...

Authors: Kim HS, Jung M, Choi SK, Woo J, Piao YJ, Hwang EH, Kim H, Kim SJ, Moon WK.

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

Background:Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-inflammatory cytokines. Various phytochemicals have been reported to contribute to the beiging of white adipose tissue...

Authors: Samuels JS1, Shashidharamurthy R1, Rayalam S1

IRF2 is a master regulator of human keratinocyte stem cell fate

Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. The stem cell potential of human epidermal keratinocytes is retained in vitro but lost over time suggesting extrinsic and intrinsic...

Authors: Mercado N, Schutzius G, Kolter C, Estoppey D, Bergling S, Roma G, Gubser Keller C, Nigsch F, Salathe...

Phosphatidylethanolamine and Phosphatidylcholine Biosynthesis by the Kennedy Pathway Occurs at Different Sites in Trypanosoma Brucei

Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are among the most abundant phospholipids in biological membranes. In many eukaryotes, the CDP-ethanolamine and CDP-choline branches of the Kennedy pathway represent major and often essential...

Authors: Luce Farine 1 , Moritz Niemann 3 , André...

SST Peer Reviewed

Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells.

Visceral fat accumulation as observed in Crohn's disease and obesity is linked to chronic gut inflammation, suggesting that accumulation of gut adipocytes can trigger local inflammatory signaling. However, direct interactions between intestinal...

Authors: Takahashi Y1, Sato S2, Kurashima Y3, Lai CY4, Otsu M4, Hayashi M5, Yamaguchi T5, Kiyono H6.

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Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

Dendritic cell MST1 inhibits Th17 differentiation.

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies.

The Replication of a Mouse Adapted SARS-CoV in a Mouse Cell Line Stably Expressing the Murine SARS-CoV Receptor mACE2 Efficiently Induces the Expression of Proinflammatory Cytokines

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression.

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

IRF2 is a master regulator of human keratinocyte stem cell fate

Phosphatidylethanolamine and Phosphatidylcholine Biosynthesis by the Kennedy Pathway Occurs at Different Sites in Trypanosoma Brucei

Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells.