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Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX.

Hemophilia B is an ideal target for gene- and cell-based therapies because of its monogenic nature and broad therapeutic index. Here, we demonstrate the use of cell therapy as a potential long-term cure for hemophilia B in our FIX-deficient mouse...

Authors: Ramaswamy S, Tonnu N, Menon T, Lewis BM, Green KT, Wampler D, Monahan PE, Verma IM.

Dendritic cell MST1 inhibits Th17 differentiation.

Although the differentiation of CD4+T cells is widely studied, the mechanisms of antigen-presenting cell-dependent T-cell modulation are unclear. Here, we investigate the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and...

Authors: Li C, Bi Y, Li Y, Yang H, Yu Q, Wang J, Wang Y, Su H, Jia A, Hu Y, Han L, Zhang J, Li S, Tao W, Liu...

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.

Despite the development of combined modality treatments against liposarcoma in recent years, a significant proportion of patients respond only modestly to such approaches, possibly contributing to local or distant recurrence. Early detection of...

Authors: Casadei L1,2, Calore F3, Creighton CJ4, Guescini M5, Batte K1,2, Iwenofu OH6, Zewdu A1,2, Braggio...

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression.

BACKGROUND:The function of preadipocytes in the progression of early stage breast cancer has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in breast cancer progression, we investigated the cross-talk between...

Authors: Kim HS, Jung M, Choi SK, Woo J, Piao YJ, Hwang EH, Kim H, Kim SJ, Moon WK.

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

Background:Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-inflammatory cytokines. Various phytochemicals have been reported to contribute to the beiging of white adipose tissue...

Authors: Samuels JS1, Shashidharamurthy R1, Rayalam S1

Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells.

Visceral fat accumulation as observed in Crohn's disease and obesity is linked to chronic gut inflammation, suggesting that accumulation of gut adipocytes can trigger local inflammatory signaling. However, direct interactions between intestinal...

Authors: Takahashi Y1, Sato S2, Kurashima Y3, Lai CY4, Otsu M4, Hayashi M5, Yamaguchi T5, Kiyono H6.

Orthotopic replacement of T-cell receptor a- and ß-chains with preservation of near-physiological T-cell function.

Therapeutic T cells with desired specificity can be engineered by introducing T-cell receptors (TCRs) specific for antigens of interest, such as those from pathogens or tumour cells. However, TCR engineering is challenging, owing to the complex...

Authors: Schober K, Müller TR, Gökmen F, Grassmann S, Effenberger M, Poltorak M, Stemberger C, Schumann K,...

SST Peer Reviewed

Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells

CRISPR/Cas9-mediated programmed cell death protein 1 (PD-1) disruption in chimeric antigen receptor (CAR) T cells could be an appealing choice to improve the therapeutic efficacy of CAR T cells in an immunosuppressive tumor microenvironment. In most...

Authors: Hu B, Zou Y, Zhang L, Tang J, Niedermann G, Firat E, Huang X, Zhu X.

SST Peer Reviewed

Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts.

The viral vector-mediated overexpression of the defined transcription factors, Brn4/Pou3f4, Sox2, Klf4, and c-Myc (BSKM), could induce the direct conversion of somatic fibroblasts into induced neural stem cells (iNSCs). However, viral vectors may be...

Authors: Kim SM, Kim JW, Kwak TH, Park SW, Kim KP, Park H, Lim KT, Kang K, Kim J, Yang JH, Han H, Lee I, Hyun...

SST Peer Reviewed

Laboratory Growth and Genetic Manipulation of Eimeria tenella.

Eimeria is a genus of apicomplexan parasites that contains a large number of species, most of which are absolutely host-specific. Seven species have been recognized to infect chickens. Infection of susceptible chickens results in an intestinal...

Authors: Pastor-Fernández I, Pegg E, Macdonald SE, Tomley FM, Blake DP, Marugán-Hernández V

SST Peer Reviewed

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Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX.

Dendritic cell MST1 inhibits Th17 differentiation.

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression.

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells.

Orthotopic replacement of T-cell receptor a- and ß-chains with preservation of near-physiological T-cell function.

Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells

Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts.

Laboratory Growth and Genetic Manipulation of Eimeria tenella.