Search Results

Activating prostaglandin E2 receptor subtype EP4 increases secreted mucin from airway goblet cells.

Prostaglandin E2 (PGE2) is a ligand of the E-type prostanoid receptors, EP1-4. PGE2 secretion is increased in the airways of patients with asthma by secretory phospholipases A2, which also increases MUC5AC mucin in goblet cells. We hypothesized that...

Authors: Akaba T, Komiya K, Suzaki I, Kozaki Y, Tamaoki J, Rubin BK

Endothelial cell diversity revealed by global expression profiling

The vascular system is locally specialized to accommodate widely varying blood flow and pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the lumens of blood and lymphatic vessels play an integral role in...

Authors: Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn...

SST Peer Reviewed

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Human immunodeficiency virus type 1 (HIV-1) infection impairs liver function, and liver diseases have become a leading cause of morbidity in infected patients. The immunopathology of liver damage caused by HIV-1 remains unclear. We used chimeric mice...

Authors: Dagur RS, Wang W, Cheng Y, Makarov E, Ganesan M, Suemizu H, Gebhart CL, Gorantla S, Osna N,...

Orthotopic replacement of T-cell receptor a- and ß-chains with preservation of near-physiological T-cell function.

Therapeutic T cells with desired specificity can be engineered by introducing T-cell receptors (TCRs) specific for antigens of interest, such as those from pathogens or tumour cells. However, TCR engineering is challenging, owing to the complex...

Authors: Schober K, Müller TR, Gökmen F, Grassmann S, Effenberger M, Poltorak M, Stemberger C, Schumann K,...

SST Peer Reviewed

Crocin reduces Aspergillus fumigatus-induced airway inflammation and NF-kappaB signal activation

Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammation and its exacerbation is often accompanied by Aspergillus fumigatus (A. fumigatus) infection. Increasing evidences demonstrated the potent antioxidant and -inflammatory...

Authors: Du J1, Chi Y1, Song Z1, Di Q1, Mai Z1, Shi J1, Li M1

Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts.

The viral vector-mediated overexpression of the defined transcription factors, Brn4/Pou3f4, Sox2, Klf4, and c-Myc (BSKM), could induce the direct conversion of somatic fibroblasts into induced neural stem cells (iNSCs). However, viral vectors may be...

Authors: Kim SM, Kim JW, Kwak TH, Park SW, Kim KP, Park H, Lim KT, Kang K, Kim J, Yang JH, Han H, Lee I, Hyun...

SST Peer Reviewed

Host-directed combinatorial RNAi improves inhibition of diverse strains of influenza A virus in human respiratory epithelial cells.

Influenza A virus infections are important causes of morbidity and mortality worldwide, and currently available prevention and treatment methods are suboptimal. In recent years, genome-wide investigations have revealed numerous host factors that are...

Authors: Estrin MA, Hussein ITM, Puryear WB, Kuan AC, Artim SC, Runstadler JA

Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin

Activation of hepatic stellate cells (HSCs) is an integral component of the wound-healing process in liver injury/inflammation. However, uncontrolled activation of HSCs leads to constant secretion of collagen-rich extracellular matrix (ECM) proteins,...

Authors: Gajendiran P, Vega LI, Itoh K, Sesaki H, Vakili MR, Lavasanifar A, Hong K, Mezey E,...

Laboratory Growth and Genetic Manipulation of Eimeria tenella.

Eimeria is a genus of apicomplexan parasites that contains a large number of species, most of which are absolutely host-specific. Seven species have been recognized to infect chickens. Infection of susceptible chickens results in an intestinal...

Authors: Pastor-Fernández I, Pegg E, Macdonald SE, Tomley FM, Blake DP, Marugán-Hernández V

SST Peer Reviewed

In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells.

Lung branching morphogenesis has been studied for decades, but the underlying developmental mechanisms are still not fully understood. Cellular movements dynamically change during the branching process, but it is difficult to observe long-term...

Authors: Hagiwara M1, Maruta N2,3, Marumoto M2

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Activating prostaglandin E2 receptor subtype EP4 increases secreted mucin from airway goblet cells.

Endothelial cell diversity revealed by global expression profiling

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Orthotopic replacement of T-cell receptor a- and ß-chains with preservation of near-physiological T-cell function.

Crocin reduces Aspergillus fumigatus-induced airway inflammation and NF-kappaB signal activation

Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts.

Host-directed combinatorial RNAi improves inhibition of diverse strains of influenza A virus in human respiratory epithelial cells.

Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin

Laboratory Growth and Genetic Manipulation of Eimeria tenella.

In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells.