Search Results

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-ß Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation.

Pulsed electromagnetic fields (PEMFs) have been documented to promote bone fracture healing in nonunions and increase lumbar spinal fusion rates. However, the molecular mechanisms by which PEMF stimulates differentiation of human bone marrow stromal...

Authors: Selvamurugan N1, He Z2, Rifkin D3, Dabovic B3, Partridge NC2

Microengineered liver tissues for drug testing

Drug-induced liver injury (DILI) is a leading cause of drug attrition. Significant and well-documented differences between animals and humans in liver pathways now necessitate the use of human-relevant in vitro liver models for testing new chemical...

Authors: Khetani SR1, Berger DR2, Ballinger KR3, Davidson MD2, Lin C2, Ware BR2

Impact of starting material (fresh versus cryopreserved marrow) on mesenchymal stem cell culture

BACKGROUND:Mesenchymal stem cells (MSCs) continue to be investigated in multiple clinical trials as potential therapy for different disorders. There is ongoing controversy surrounding the clinical use of cryopreserved versus fresh MSCs. However,...

Authors: Kaplan A1,2, Sackett K3, Sumstad D4, Kadidlo D4, McKenna DH3,4

A Cell-type-resolved Liver Proteome

Parenchymatous organs consist of multiple cell types, primarily defined as parenchymal cells (PCs) and nonparenchymal cells (NPCs). The cellular characteristics of these organs are not well understood. Proteomic studies facilitate the resolution of...

Authors: Ding C1, Li Y2, Guo F3, Jiang Y3, Ying W3, Li D3, Yang D3, Xia X3, Liu W3, Zhao Y3, He Y4, Li X3,...

Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts.

Gene amplifications are an attribute of tumor cells and have for long time been overlooked in normal cells. A growing number of investigations describe gene amplifications in normal mammalian cells during development and differentiation. Possibly,...

Authors: Altmayer NC1, Galata V2, Warschburger N1, Keller A2, Meese E1, Fischer U1

Long-term culture and expansion of primary human hepatocytes

Hepatocytes have a critical role in metabolism, but their study is limited by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. Here we describe the oncostatin M (OSM)-dependent...

Authors: Levy G, Bomze D, Heinz S, Ramachandran SD, Noerenberg A, Cohen M, Shibolet O, Sklan E, Braspenning...

A biomaterials approach to influence stem cell fate in injectable cell-based therapies.

BACKGROUND:Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This study investigated the effects of...

Authors: Amer MH1, Rose FRAJ1, Shakesheff KM1, White LJ2

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment.

ONC201 is a first-in-class, orally active antitumor agent that upregulates cytotoxic TRAIL pathway signaling in cancer cells. ONC201 has demonstrated safety and preliminary efficacy in a first-in-human trial in which patients were dosed every 3...

Authors: Wagner J1, Kline CL1, Zhou L1, Campbell KS2, MacFarlane AW2, Olszanski AJ3, Cai KQ4, Hensley HH5,...

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

Individual variability in cytochrome P450 (P450) induction comprises an important component contributing to the difficulties in assessing and predicting metabolism-based drug-drug interactions in humans. In this article, we outline the major factors...

Authors: Tang C1, Lin JH, Lu AY

Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields.

Pulsed electromagnetic fields (PEMFs) have been used to treat bone diseases, particularly nonunion healing. Although it is known that PEMFs promote the osteogenic differentiation of human mesenchymal stem cells (hMSCs), to date PEMF molecular...

Authors: Bagheri L1, Pellati A1, Rizzo P1, Aquila G2,3, Massari L1, De Mattei M1, Ongaro A1.

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin