Search Results

The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation

The TRAP220 subunit of the thyroid hormone receptor-associated polypeptide transcription coactivator complex (TRAP/Mediator complex), mammalian counterpart of the yeast Mediator complex, is proposed to act on a variety of major and specific...

Authors: Urahama N, Ito M, Sada A, Yakushijin K, Yamamoto K, Okamura A, Minagawa K, Hato A, Chihara K, Roeder...

The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells

Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan. The superoxide-producing NAD(P)H oxidase Nox4 was initially identified as an enzyme that is highly expressed in the kidney and is possibly involved in oxygen...

Authors: Kuroda J, Nakagawa K, Yamasaki T, Nakamura K, Takeya R, Kuribayashi F, Imajoh-Ohmi S, Igarashi K,...

Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in MDCK cells

The Ca2+-independent immunoglobulin-like molecule nectin first forms cell-cell adhesions and then assembles cadherin at nectin-based cell-cell adhesion sites, resulting in the formation of adherens junctions (AJs). Afadin is a nectin- and actin...

Authors: Sato T, Fujita N, Yamada A, Ooshio T, Okamoto R, Irie K and Takai Y

Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells

Stimulation of resting CD4 T cells with anti-CD3/CD28-coated beads leads to rapid polarization of lipid rafts (LRs). It has been postulated that a major role of costimulation is to facilitate LR aggregation. CD86 is up-regulated or expressed...

Authors: Kovacs B, Parry RV, Ma Z, Fan E, Shivers DK, Freiberg BA, Thomas AK, Rutherford R, Rumbley CA, Riley...

Interrelated roles for Mcl-1 and Bim in regulation of TRAIL-mediated mitochondrial apoptosis

The current study demonstrates a novel cross-talk mechanism between the TRAIL receptor death signaling pathway and the mitochondria. This newly identified pathway is regulated at the mitochondrial outer membrane by a complex between the prosurvival...

Authors: Han J, Goldstein LA, Gastman BR, Rabinowich H

Ceramide mediates caspase-independent programmed cell death

Although numerous studies have implicated the sphingolipid ceramide in the induction of cell death, a causative function of ceramide in caspase-dependent apoptosis remains a highly debated issue. Here, we show that ceramide is a key mediator of a...

Authors: Thon L, Mohlig H, Mathieu S, Lange A, Bulanova E, Winoto-Morbach S, Schutze S, Bulfone-Paus S and...

Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase

Heme oxygenase-1 (HO-1) is the rate limiting enzyme of heme catabolism whereas indoleamine 2,3 dioxygenase (IDO) catabolizes tryptophan through the kynurenine pathway. We analyzed the expression and biological effects of these enzymes in rat and...

Authors: Hill M, Pereira V, Chauveau C, Zagani R, Remy S, Tesson L, Mazal D, Ubillos L, Brion R, Ashgar K,...

T-bet binding to newly identified target gene promoters is cell-type independent, but results in variable context-dependent functional effects

Recently developed target gene identification strategies based upon the chromatin immunoprecipitation assay provide a powerful method to determine the localization of transcription factor binding within mammalian genomes. However, in many cases, it...

Authors: Beima KM, Miazgowicz MM, Lewis MD, Yan PS, Huang TH, Weinmann AS

Identification of Spliced Gammaherpesvirus 68 LANA and v-Cyclin Transcripts and Analysis of Their Expression In Vivo during Latent Infection

Regulation of orf73 (LANA) gene expression is critical to the establishment and maintenance of latency following infection by members of the gamma-2 herpesvirus (rhadinovirus) family. Previous studies of murine gammaherpesvirus 68 (gammaHV68) have...

Authors: Allen RD 3rd, Dickerson S and Speck SH

SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling

Anaplastic Large Cell Lymphoma (ALCL) is frequently associated with the 2;5 translocation and expresses the NPM-ALK fusion protein which possesses a constitutive tyrosine kinase activity. We analysed SHP1 tyrosine-phosphatase expression and activity...

Authors: Honorat JF, Ragab A, Lamant L, Delsol G, Ragab-Thomas J

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin