Search Results

Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.

Prostacyclin (PGI2) is a potent vasodilator and important mediator of vascular homeostasis; however, its clinical use is limited because of its short (<2-min) half-life. Thus, we hypothesize that the use of engineered endothelial progenitor cells...

Authors: Liu Q, Xi Y, Terry T, So SP, Mohite A, Zhang J, Wu G, Liu X, Cheng J, Ruan KH, Willerson JT, Dixon...

Paracrine induction of endothelium by tumor exosomes

Cancers use a nanoscale messenger system known as exosomes to communicate with surrounding tissues and immune cells. However, the functional relationship between tumor exosomes, endothelial signaling, angiogenesis, and metastasis is poorly...

Authors: Joshua L. Hood, Hua Pan, Gregory M. Lanza and Samuel A. Wickline

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

Background: Only a few exposure systems are presently available that enable cigarette smoke exposure of living cells at the air–liquid interface, of which one of the most versatile is the Vitrocell® system (Vitrocell® Systems GmbH). To assess its...

Authors: Shoaib Majeed, Stefan Frentzel, Sandra Wagner, Diana Kuehn, Patrice Leroy, Philippe A Guy, Arno...

Improving Viability and Transfection Efficiency with Human Umbilical Cord Wharton 's Jelly Cells Through Use of a ROCK Inhibitor

Differentiating stem cells using gene delivery is a key strategy in tissue engineering and regenerative medicine applications. Nonviral gene delivery bypasses several safety concerns associated with viral gene delivery; however, leading nonviral...

Authors: Mellott AJ, Godsey ME, Shinogle HE, Moore DS, Forrest ML, Detamore MS.

Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells

PURPOSE: The lung is one of the most common sites of breast cancer metastasis. While metastatic seeding is often accompanied by a dormancy-promoting mesenchymal to epithelial reverting transitions (MErT), we aimed to determine whether lung...

Authors: Furukawa M, Wheeler S, Clark AM, Wells A

SST Peer Reviewed

Heating during infrared neural stimulation.

BACKGROUND AND OBJECTIVE: Infrared neural stimulation (INS) has recently evoked interest as an alternative to electrical stimulation. The mechanism of activation is the heating of water, which induces changes in cell membrane potential but may...

Authors: Liljemalm R, Nyberg T, von Holst H.

Interactions between aCaMKII and calmodulin in living cells: conformational changes arising from CaM-dependent and -independent relationships

BACKGROUND: aCaMKII plays central and essential roles in long-term potentiation (LTP), learning and memory. aCaMKII is activated via binding with Ca²?/CaM in response to elevated Ca²? concentration. Furthermore, prolonged increase in Ca²?...

Authors: Kato K, Iwamoto T, Kida S.

Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host

Bats of different species play a major role in the emergence and transmission of highly pathogenic viruses including Ebola virus, SARS-like coronavirus and the henipaviruses. These viruses require proteolytic activation of surface envelope...

Authors: El Najjar F, Lampe L, Baker ML, Wang LF, Dutch RE

SST Peer Reviewed

GABA blocks pathological but not acute TRPV1 pain signals.

Sensitization of the capsaicin receptor TRPV1 is central to the initiation of pathological forms of pain, and multiple signaling cascades are known to enhance TRPV1 activity under inflammatory conditions. How might detrimental escalation of TRPV1...

Authors: Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A,...

SST Peer Reviewed

The excimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model.

Epidermal hyperinnervation, which is thought to underlie intractable pruritus, has been observed in patients with atopic dermatitis (AD). The epidermal expression of axonal guidance molecules has been reported to regulate epidermal hyperinnervation....

Authors: Kamo A, Tominaga M, Kamata Y, Kaneda K, Ko K2, Matsuda H, Kimura U, Ogawa H, Takamori K.

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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.

Paracrine induction of endothelium by tumor exosomes

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

Improving Viability and Transfection Efficiency with Human Umbilical Cord Wharton 's Jelly Cells Through Use of a ROCK Inhibitor

Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells

Heating during infrared neural stimulation.

Interactions between aCaMKII and calmodulin in living cells: conformational changes arising from CaM-dependent and -independent relationships

Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host

GABA blocks pathological but not acute TRPV1 pain signals.

The excimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model.