Search Results

Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia

The two B-cell non-Hodgkin's lymphoma entities, chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), show recurrent chromosomal gains of 3q25-q29, 12q13-q14 and 18q21-q22. The pathomechanisms affected by these aberrations are not...

Authors: Farfsing A, Engel F, Seiffert M, Hartmann E, Ott G, Rosenwald A, Stilgenbauer S, Döhner H, Boutros...

SST Peer Reviewed

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein with intra- and extra-cellular functions as an enzyme, cytokine, growth factor, and hormone. NAMPT is of interest for oncology, because it catalyzes the rate-limiting step in the...

Authors: Zabka TS, Singh J, Dhawan P, Liederer BM, Oeh J, Kauss MA, Xiao Y, Zak M, Lin T, McCray B, La N,...

SST Peer Reviewed

Inhibition of SGLT1 abrogates preconditioning-induced cardioprotection against ischemia-reperfusion injury

BACKGROUND: Recently, we reported Na+/glucose co-transporter (SGLT1) expression in mouse and human heart. We speculated that SGLT1 might play an important role in ischemic preconditioning-induced cardioprotection. Therefore, the present study was...

Authors: Kanwal A, Nizami HL, Mallapudi S, Putcha UK, Mohan GK, Banerjee SK

SST Peer Reviewed

A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19

The advent of efficient approaches to the genetic modification of T cells has provided investigators with clinically appealing methods to improve the potency of tumor-specific clinical grade T cells. For example, gene therapy has been successfully...

Authors: Singh H Huls H Kebriaei P Cooper LJ

SST Peer Reviewed

Long-term electromagnetic exposure of developing neuronal networks: A flexible experimental setup

Neuronal networks in vitro are considered one of the most promising targets of research to assess potential electromagnetic field induced effects on neuronal functionality. A few exposure studies revealed there is currently no evidence of any adverse...

Authors: Oster S, Daus AW, Erbes C, Goldhammer M, Bochtler U, Thielemann C

SST Peer Reviewed

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

The extant jawless vertebrates, represented by lampreys and hagfish, are the oldest group of vertebrates and provide an interesting genomic evolutionary pivot point between invertebrates and jawed vertebrates. Through genome analysis of one of these...

Authors: Cynthia R. Coffill, Alison P. Lee, Jia Wei Siau, Sharon M. Chee, Thomas L. Joseph, Yaw Sing Tan,...

Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform.

Chimeric antigen receptor (CAR)-modified T-cell adoptive immunotherapy is a remarkable therapeutic option proven effective in the treatment of hematological malignancies. In order to optimize cell manufacturing, we sought to develop a novel...

Authors: Magnani CF1, Turazzi N1, Benedicenti F2, Calabria A2, Tenderini E2, Tettamanti S1, Giordano...

SST Peer Reviewed

Macrophage PI3K? Drives Pancreatic Ductal Adenocarcinoma Progression

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a low 5-year survival rate, yet new immunotherapeutic modalities may offer hope for this and other intractable cancers. Here, we report that inhibitory targeting of PI3K?, a key...

Authors: Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E,...

SST Peer Reviewed

Peen treatment on a titanium implant: effect of roughness, osteoblast cell functions, and bonding with bone cement

Implant failure due to poor integration of the implant with the surrounding biomaterial is a common problem in various orthopedic and orthodontic surgeries. Implant fixation mostly depends upon the implant surface topography. Micron to nanosize...

Authors: Khandaker M, Riahinezhad S, Sultana F, Vaughan MB, Knight J, Morris TL

SST Peer Reviewed

Real architecture For 3D Tissue (RAFT™) culture system improves viability and maintains insulin and glucagon production of mouse pancreatic islet cells.

There is an unmet medical need for the improvement of pancreatic islet maintenance in culture. Due to restricted donor availability it is essential to ameliorate islet viability and graft engraftment. The aim of this study was to compare the standard...

Authors: Szebeni GJ, Tancos Z, Feher LZ, Alfoldi R, Kobolak J, Dinnyes A, Puskas LG

SST Peer Reviewed

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Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Inhibition of SGLT1 abrogates preconditioning-induced cardioprotection against ischemia-reperfusion injury

A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19

Long-term electromagnetic exposure of developing neuronal networks: A flexible experimental setup

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform.

Macrophage PI3K? Drives Pancreatic Ductal Adenocarcinoma Progression

Peen treatment on a titanium implant: effect of roughness, osteoblast cell functions, and bonding with bone cement

Real architecture For 3D Tissue (RAFT™) culture system improves viability and maintains insulin and glucagon production of mouse pancreatic islet cells.