Search Results

Non-adherent mesenchymal progenitors from adipose tissue stromal vascular fraction

In primary human bone marrow cultures, the initial adherent cell fraction has been shown to provide a microenvironment for self-renewal of primitive non-adherent mesenchymal progenitors (non-adherent progenitors of bone marrow stroma [BM-NAMP]), with...

Authors: Mehrkens A1, Di Maggio N, Gueven S, Schaefer D, Scherberich A, Banfi A, Martin I

Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma

Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells. Here we show that PEDF expression...

Authors: Fernández-Barral A, Orgaz JL, Baquero P, Ali Z, Moreno A, Tiana M, Gómez V, Riveiro-Falkenbach E,...

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

The CRISPR/Cas9 system is a robust genome editing technology that works in human cells, animals and plants based on the RNA-programmed DNA cleaving activity of the Cas9 enzyme. Building on previous work (Jinek et al., 2013), we show here that new...

Authors: Lin S, Staahl BT, Alla RK, Doudna JA.

Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.

Thyroid hormone and thyroid hormone receptor (TR) play an essential role in metabolic regulation. However, the role of TR in adipogenesis has not been established. We reported previously that TR sumoylation is essential for TR-mediated gene...

Authors: Liu YY, Ayers S, Milanesi A, Teng X, Rabi S, Akiba Y, Brent GA

SST Peer Reviewed

Myosin Vc interacts with Rab32 and Rab38 and works in the biogenesis and secretion of melanosomes

Class V myosins are actin-based motors with conserved functions in vesicle and organelle trafficking. Herein, we report the discovery of a function for Myosin Vc in melanosome biogenesis as an effector of melanosome-associated Rab GTPases. We...

Authors: Bultema JJ, Boyle JA, Malenke PB, Martin FE, Dell\\\'Angelica EC, Cheney RE, Di Pietro SM

Kaposi's Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis

KSHV is the etiologic agent for Kaposi's sarcoma (KS), a neoplasm that manifests most aggressively as multifocal lesions on parts of human skin with a propensity for inflammatory reactivity. However, mechanisms that control evolution of KS from a...

Authors: Fontana JM, Mygatt JG, Conant KL, Parsons CH, Kaleeba JA

Apolipoprotein A-I truncations in Chagas disease are caused by cruzipain, the major cysteine protease of Trypanosoma cruzi

Trypanosoma cruzi is the etiologic agent of Chagas disease. Approximately 10 million people are infected worldwide. We have previously reported that in individuals infected with T. cruzi, apolipoprotein A-I (Apo A-I), the major structural component...

Authors: Miao Q, Santamaria C, Bailey D, Genest J, Ward BJ, Ndao M

SST Peer Reviewed

Possible Mechanism of Low Endotoxin Recovery

Authors: M.Tsuchiya

Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles

BACKGROUND: In addition to alterations concerning the expression of oncogenes and onco-suppressors, melanoma is characterized by the presence of distinctive gangliosides (sialic acid carrying glycosphingolipids). Gangliosides strongly control cell...

Authors: Tringali C, Silvestri I, Testa F, Baldassari P, Anastasia L, Mortarini R, Anichini A, López-Requena...

Carbon nanotube fibers are compatible with Mammalian cells and neurons.

We demonstrate the biocompatibility of carbon nanotube fibers (CNFs) fabricated from single-wall carbon nanotubes. Produced by a particle-coagulation spinning process, CNFs are "hair-like" conductive microwires, which uniquely combine properties of...

Authors: Dubin RA, Callegari G, Kohn J, Neimark A.

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin