Search Results

Distinct effects of EGFR ligands on human mammary epithelial cell differentiation

Based on gene expression patterns, breast cancers can be divided into subtypes that closely resemble various developmental stages of normal mammary epithelial cells (MECs). Thus, understanding molecular mechanisms of MEC development is expected to...

Authors: Mukhopadhyay C1, Zhao X, Maroni D, Band V, Naramura M.

Simple and rapid molecular techniques for identification of amylose levels in rice varieties

The polymorphisms of Waxy (Wx) microsatellite and G-T single-nucleotide polymorphism (SNP) in the Wx gene region were analyzed using simplified techniques in fifteen rice varieties. A rapid and reliable electrophoresis method, MetaPhor agarose gel...

Authors: Cheng A, Ismail I, Osman M, Hashim H.

Photorhabdus luminescens PirAB-fusion protein exhibits both cytotoxicity and insecticidal activity.

The binary toxin 'Photorhabdus insect-related' proteins (PirAB) produced by Photorhabdus luminescens have been reported to possess both injectable and oral activities against a range of insects. Here, PirAB-fusion protein was constructed by linking...

Authors: Li Y1, Hu X, Zhang X, Liu Z, Ding X, Xia L, Hu S.

Multilocus microsatellite signature and identification of specific molecular markers for Leishmania aethiopica

BACKGROUND: Leishmaniasis is a clinically and epidemiologically diverse zoonotic disease caused by obligatory, intracellular protozoan parasites of the genus Leishmania. Cutaneous leishmaniasis is the most widely distributed form of the disease...

Authors: Kebede N, Oghumu S, Worku A, Hailu A, Varikuti S, Satoskar AR.

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland

The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial...

Authors: Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B,...

Agarose hydrogels embedded with pH-responsive diblock copolymer micelles for triggered release of substances

Hybrid agarose hydrogels embedded with pH-responsive diblock copolymers micelles were developed to achieve functional hydrogels capable of stimulus-triggered drug release. Specifically, a well-defined poly(ethylene oxide) (PEO)-based diblock...

Authors: Jin N, Morin EA, Henn DM, Cao Y, Woodcock JW, Tang S, He W, Zhao B

Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.

Through a rational design approach, we generated a panel of HLA-A*0201/NY-ESO-1(157-165)-specific T cell receptors (TCR) with increasing affinities of up to 150-fold from the wild-type TCR. Using these TCR variants which extend just beyond the...

Authors: Irving M1, Zoete V, Hebeisen M, Schmid D, Baumgartner P, Guillaume P, Romero P, Speiser D, Luescher...

Efficient expression of acetylcholine-binding protein from Aplysia californica in Bac-to-Bac system.

The Bac-to-Bac baculovirus expression system can efficiently produce recombinant proteins, but the system may have to be optimized to achieve high-level expression for different candidate proteins. We reported here the efficient expression of...

Authors: Lin B1, Meng H1, Bing H1, Zhangsun D1, Luo S1.

SST Peer Reviewed

In vitro antitumor activity of stellettin B, a triterpene from marine sponge Jaspis stellifera, on human glioblastoma cancer SF295 cells

Stellettin B was isolated from marine sponge Jaspis stellifera. In vitro antitumor activities were investigated on 39 human cancer cell lines. Stellettin B exhibited highly potent inhibition against the growth of a human glioblastoma cell line SF295,...

Authors: Tang SA, Zhou Q, Guo WZ, Qiu Y, Wang R, Jin M, Zhang W, Li K, Yamori T, Dan S, Kong D

Autocrine signaling is a key regulatory element during osteoclastogenesis

Osteoclasts are responsible for bone destruction in degenerative, inflammatory and metastatic bone disorders. Although osteoclastogenesis has been well-characterized in mouse models, many questions remain regarding the regulation of osteoclast...

Authors: Kopesky P1, Tiedemann K2, Alkekhia D1, Zechner C1, Millard B1, Schoeberl B1, Komarova SV3

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