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Human Mesenchymal Stem Cells Display Reduced Expression of CD105 after Culture in Serum-Free Medium.

Human Mesenchymal Stem Cells (hMSCs) present a promising tool for regenerative medicine. However, ex vivo expansion is necessary to obtain sufficient cells for clinical therapy. Conventional growth media usually contain the critical component fetal...

Authors: Mark P, Kleinsorge M, Gaebel R, Lux CA, Toelk A, Pittermann E, David R, Steinhoff G, Ma N

SST Peer Reviewed

Cigarette smoke modulates rhinovirusinduced airway epithelial cell chemokine production

Human rhinovirus (HRV) infections induce epithelial cell production of chemokines that may contribute to the pathogenesis of exacerbations of chronic obstructive pulmonary disease (COPD) and asthma. Cigarette smoking is the predominant risk factor...

Authors: M.H. Hudy, S.L. Traves, S. Wiehler and D. Proud

DNA packaging-associated hyper-capsid expansion of bacteriophage t3

Evidence that in vivo bacteriophage T3 DNA packaging includes capsid hyper-expansion that is triggered by lengthening of incompletely packaged DNA (ipDNA) is presented here. This evidence includes observation that some of the longer ipDNAs in...

Authors: Serwer P, Wright ET, Hakala K, Weintraub ST, Su M, Jiang W.

Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles

Microparticles (MP) are phospholipid vesicles shed by cells upon activation or apoptosis. Monocyte-derived MP upregulate the synthesis of proinflammatory mediators by lung epithelial cells; the molecular bases of such activity are unknown....

Authors: Neri T, Armani C, Pegoli A, Cordazzo C, Carmazzi Y, Brunelleschi S, Bardelli C, Breschi MC, Paggiaro...

Extrasynaptic glutamate NMDA receptors: Key players in striatal function.

N-methyl-d-aspartate receptors (NMDAR) are crucial for the function of excitatory neurotransmission and are present at the synapse and on the extrasynaptic membrane. The major nucleus of the basal ganglia, striatum, receives a large glutamatergic...

Authors: Garcia-Munoz M, Lopez-Huerta VG, Carrillo-Reid L, Arbuthnott GW

SST Peer Reviewed

Development of quantitative PCR assays targeting the 16S rRNA genes of Enterococcus spp. and their application to the identification of enterococcus species in environmental samples

The detection of environmental enterococci has been determined primarily by using culture-based techniques that might exclude some enterococcal species as well as those that are nonculturable. To address this, the relative abundances of enterococci...

Authors: Ryu H, Henson M, Elk M, Toledo-Hernandez C, Griffith J, Blackwood D, Noble R, Gourmelon M,...

Zitzmann K, Ailer G, Vlotides G, Spoettl G, Maurer J, Göke B, Beuschlein F, Auernhammer CJ.

The heat shock protein (HSP) 90 chaperone machine involved in numerous oncogenic signaling pathways is overexpressed in cancer cells and is currently being evaluated for anticancer therapy. Neuroendocrine tumors (NETs) of the gastroenteropancreatic...

Authors: Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine...

Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone.

Matrix metalloproteinase-9 is implicated in airway inflammation and airway remodeling in asthma. We have previously confirmed that human rhinovirus-16 (HRV-16) infection increases MMP-9 expression both in vivo and in vitro. However, the role of the...

Authors: Tacon CE, Newton R, Proud D, Leigh R.

Ischemic stroke brain sends indirect cell death signals to the heart.

BACKGROUND AND PURPOSE: Ischemic stroke is a leading cause of mortality and morbidity in the world and may be associated with cardiac myocyte vulnerability. However, it remains uncertain how an ischemic brain contributes to cardiac alternations....

Authors: Ishikawa H, Tajiri N, Vasconcellos J, Kaneko Y, Mimura O, Dezawa M, Borlongan CV

SST Peer Reviewed

Efficacy of a novel class of RNA interference therapeutic agents

RNA interference (RNAi) is being widely used in functional gene research and is an important tool for drug discovery. However, canonical double-stranded short interfering RNAs are unstable and induce undesirable adverse effects, and thus there is no...

Authors: Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D\\\'Alessandro-Gabazza CN, Gil-Bernabe P,...

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Human Mesenchymal Stem Cells Display Reduced Expression of CD105 after Culture in Serum-Free Medium.

Cigarette smoke modulates rhinovirusinduced airway epithelial cell chemokine production

DNA packaging-associated hyper-capsid expansion of bacteriophage t3

Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles

Extrasynaptic glutamate NMDA receptors: Key players in striatal function.

Development of quantitative PCR assays targeting the 16S rRNA genes of Enterococcus spp. and their application to the identification of enterococcus species in environmental samples

Zitzmann K, Ailer G, Vlotides G, Spoettl G, Maurer J, Göke B, Beuschlein F, Auernhammer CJ.

Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone.

Ischemic stroke brain sends indirect cell death signals to the heart.

Efficacy of a novel class of RNA interference therapeutic agents