Search Results

A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes

Signal transduction to nuclear factor-kappa B (NF-?B) involves multiple kinases and phosphorylated target proteins, but little is known about signal termination by dephosphorylation. By RNAi screening, we have identified protein phosphatase 4...

Authors: Brechmann M, Mock T, Nickles D, Kiessling M, Weit N, Breuer R, Müller W, Wabnitz G, Frey F, Nicolay...

SST Peer Reviewed

THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection.

Human cytomegalovirus (HCMV) infects about 50% of the US population, is the leading infectious cause of birth defects, and is considered the most important infectious agent in transplant recipients. The virus infects many cell types in vivo and in...

Authors: Li Q, Wilkie AR, Weller M, Liu X, Cohen JI.

A Rapid and Low-Cost PCR Thermal Cycler for Infectious Disease Diagnostics

The ability to make rapid diagnosis of infectious diseases broadly available in a portable, low-cost format would mark a great step forward in global health. Many molecular diagnostic assays are developed based on using thermal cyclers to carry out...

Authors: Chan K, Wong PY, Yu P, Hardick J, Wong KY1, Wilson SA, Wu T, Hui Z, Gaydos C, Wong SS

Clinical features of children hospitalized with influenza A and B infections during the 2012-2013 influenza season in Italy

BACKGROUND: Influenza is a major public health issue worldwide. It is characterized by episodes of infection that involve hundreds of millions of people each year. Since that in the seasons 2010-2011 and 2011-2012 the circulation of FLUB was...

Authors: Mancinelli L, Onori M, Concato C, Sorge R, Chiavelli S, Coltella L, Raucci U, Reale A, Menichella D,...

SST Peer Reviewed

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.

BACKGROUND: T cells expressing antigen-specific chimeric antigen receptors (CARs) improve outcomes for CD19-expressing B cell malignancies. We evaluated a human application of T cells that were genetically modified using the Sleeping Beauty (SB)...

Authors: Kebriaei P, Singh H, Huls MH, Figliola MJ, Bassett R, Olivares S, Jena B, Dawson MJ, Kumaresan PR,...

SST Peer Reviewed

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.

The repair outcomes at site-specific DNA double-strand breaks (DSBs) generated by the RNA-guided DNA endonuclease Cas9 determine how gene function is altered. Despite the widespread adoption of CRISPR-Cas9 technology to induce DSBs for genome...

Authors: van Overbeek M, Capurso D, Carter MM, Thompson MS, Frias E, Russ C, Reece-Hoyes JS, Nye C, Gradia S,...

SST Peer Reviewed

Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand

Photodynamic therapy that uses photosensitizers which only become toxic upon light-irradiation provides a strong alternative to conventional cancer treatment due to its ability to selectively target tumour material without affecting healthy tissue....

Authors: Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein...

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus.

Zika virus (ZIKV) was discovered in 1947 and was thought to lead to relatively mild disease. The recent explosive outbreak of ZIKV in South America has led to widespread concern, with reports of neurological sequelae ranging from Guillain Barré...

Authors: Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T, Sakuntabhai A,...

Development of real-time reverse transcriptase qPCR assays for the detection of Punta Toro virus and Pichinde virus

BACKGROUND: Research with high biocontainment pathogens such as Rift Valley fever virus (RVFV) and Lassa virus (LASV) is expensive, potentially hazardous, and limited to select institutions. Surrogate pathogens such as Punta Toro virus (PTV) for...

Authors: Stefan CP, Chase K, Coyne S, Kulesh DA, Minogue TD, Koehler JW

Bromodeoxyuridine does not contribute to sister chromatid exchange events in normal or Bloom syndrome cells.

Sister chromatid exchanges (SCEs) are considered sensitive indicators of genome instability. Detection of SCEs typically requires cells to incorporate bromodeoxyuridine (BrdU) during two rounds of DNA synthesis. Previous studies have suggested that...

Authors: van Wietmarschen N, Lansdorp PM

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A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes

THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection.

A Rapid and Low-Cost PCR Thermal Cycler for Infectious Disease Diagnostics

Clinical features of children hospitalized with influenza A and B infections during the 2012-2013 influenza season in Italy

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.

Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus.

Development of real-time reverse transcriptase qPCR assays for the detection of Punta Toro virus and Pichinde virus

Bromodeoxyuridine does not contribute to sister chromatid exchange events in normal or Bloom syndrome cells.