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Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells

BACKGROUND: Liposarcomas are the most common class of soft tissue sarcomas, and myxoid liposarcoma is the second most common liposarcoma. EWSR1-DDIT3 is a chimeric fusion protein generated by the myxoid liposarcoma-specific chromosomal...

Authors: Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M,...

SST Peer Reviewed

EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient viral replication

The hepatitis C virus (HCV) genome contains numerous RNA elements that are required for its replication. Most of the identified RNA structures are located within the 5' and 3' untranslated regions (UTRs). One prominent RNA structure, termed the...

Authors: Oakland TE, Haselton KJ, Randall G.

Resistin-like molecule-ß is a human airway remodelling mediator.

Though implicated in vascular remodelling, a role for the resistin-like molecule (RELM)-ß in human airway remodelling remains unexplored. We hypothesised that RELM-ß expression is increased in the airways of asthmatics and regulates airways...

Authors: Fang C, Meng Q, Wu H, Eid G, Zhang G, Zhang X, Yang S, Huang K, Lee TH, Corrigan CJ, Ying S.

Mesenchymal Stem Cells Conditioned Media Suppress Inflammation Associated Over-proliferation of Pulmonary Artery Smooth Muscle Cells in a Rat Model of Pulmonary Hypertension

Inflammation associated over-proliferation of pulmonary artery smooth muscle cells (PASMCs) is considered to be involved in the pathogenesis of pulmonary hypertension (PH). Even though administration of mesenchymal stem cells conditioned media...

Authors: Liu JF, Han Z, Han ZC, HeZX

SST Peer Reviewed

A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity

Rad54 is a dsDNA-dependent ATPase that translocates on duplex DNA. Its ATPase function is essential for homologous recombination, a pathway critical for meiotic chromosome segregation, repair of complex DNA damage, and recovery of stalled or broken...

Authors: Zhang XP, Janke R1, Kingsley J1, Luo J1, Fasching C1, Ehmsen KT1, Heyer WD2

Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing required.

Primary ciliary dyskinesia (PCD) results in chronic nasal symptoms and chest disease leading to bronchiectasis. We noted a number of patients referred for diagnostic testing whose initial results suggested PCD due to an inner dynein arm or radial...

Authors: C. O’Callaghan, A. Rutman, G.M. Williams and R.A. Hirst

Agarose gel electrophoresis reveals structural fluidity of a phage T3 DNA packaging intermediate

We find a new aspect of DNA packaging-associated structural fluidity for phage T3 capsids. The procedure is (i) glutaraldehyde cross-linking of in vivo DNA packaging intermediates for the stabilization of structure and then (ii) determining effective...

Authors: Serwer P, Wright ET

Mesenchymal Stem Cells Suppress Can/nfat Expression in Pulmonary Artery of Rat with Pulmonary Hypertension

OBJECTIVE: Inflammation and over-proliferation of pulmonary artery smooth muscle cells (PASMCs) have been considered as the major pathological features of pulmonary hypertension (PH). Here we aimed to determine that mesenchymal stem cells (MSCs)...

Authors: Liu JF, Han Z, Wu M, Han ZC, He ZX

SST Peer Reviewed

Effect of oxidative stress on respiratory epithelium from children with Down syndrome

Children with Down syndrome are at high risk for acute respiratory distress syndrome. In Down syndrome, both regulation of inflammation and apoptosis, important in acute respiratory distress syndrome pathophysiology, are abnormal. This has been...

Authors: Bruijn M, Lutter R, Eldering E, Bos AP, van Woensel JB.

The dimeric SOS mutagenesis protein UmuD is active as a monomer

The homodimeric umuD gene products play key roles in regulating the cellular response to DNA damage in Escherichia coli. UmuD(2) is composed of 139-amino acid subunits and is up-regulated as part of the SOS response. Subsequently, damage-induced...

Authors: Ollivierre JN, Sikora JL, Beuning PJ.

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Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells

EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient viral replication

Resistin-like molecule-ß is a human airway remodelling mediator.

Mesenchymal Stem Cells Conditioned Media Suppress Inflammation Associated Over-proliferation of Pulmonary Artery Smooth Muscle Cells in a Rat Model of Pulmonary Hypertension

A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity

Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing required.

Agarose gel electrophoresis reveals structural fluidity of a phage T3 DNA packaging intermediate

Mesenchymal Stem Cells Suppress Can/nfat Expression in Pulmonary Artery of Rat with Pulmonary Hypertension

Effect of oxidative stress on respiratory epithelium from children with Down syndrome

The dimeric SOS mutagenesis protein UmuD is active as a monomer