Search Results

Administrations of peripheral blood CD34-positive cells contribute to medial collateral ligament healing via vasculogenesis.

Neoangiogenesis is a key process in the initial phase of ligament healing. Adult human circulating CD34+ cells, an endothelial/hematopoietic progenitor-enriched cell population, have been reported to contribute to neoangiogenesis; however, the...

Authors: Tei K, Matsumoto T, Mifune Y, Ishida K, Sasaki K, Shoji T, Kubo S, Kawamoto A, Asahara T, Kurosaka...

SST Peer Reviewed

Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells.

By fostering cell commitment to the epithelial-to-mesenchymal transition (EMT), SNAIL proteins endow cells with motility, thereby favoring the metastatic spread of tumor cells. Whether the phenotypic change additionally facilitates tumor initiation...

Authors: Gras B, Jacqueroud L, Wierinckx A, Lamblot C, Fauvet F, Lachuer J, Puisieux A, Ansieau S

Fast and Efficient Neural Conversion of Human Hematopoietic Cells

Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often slow, complex, and inefficient....

Authors: Castaño J, Menendez P, Bruzos-Cidon C, Straccia M, Sousa A5, Zabaleta L, Vazquez N, Zubiarrain A,...

SST Peer Reviewed

Simplified proteomics approach to discover protein-ligand interactions

Identifying targets of biologically active small molecules is an essential but still challenging task in drug research and chemical genetics. Energetics-based target identification is an approach that utilizes the change in the conformational...

Authors: Chang Y, Schlebach JP, VerHeul RA, Park C.

Antenatal glucocorticoid therapy accelerates ATP production with creatine kinase increase in the growth-enhanced fetal rat heart

BACKGROUND: Previous study has demonstrated the increase of several cardiac function-related proteins, including creatine kinase (CK) as an important enzyme in the process of ATP synthesis in the fetal heart of rats administered glucocorticoid...

Authors: Mizuno M, Takeba Y, Matsumoto N, Tsuzuki Y, Asoh K, Takagi M, Kobayashi S, Yamamoto H

SST Peer Reviewed

A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem (iPS) cells

A systematic evaluation of three different methods for generating induced pluripotent stem (iPS) cells was performed using the same set of parental cells in our quest to develop a feeder independent and xeno-free method for somatic cell reprogramming...

Authors: Goh PA, Caxaria S, Casper C, Rosales C, Warner TT, Coffey PJ, Nathwani AC

SST Peer Reviewed

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress

Cellular stress responses are frequently governed by the subcellular localization of critical effector proteins. Apoptosis-inducing Factor (AIF) or Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH), for example, can translocate from mitochondria to...

Authors: Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV,...

A Polymer-based Piezoelectric Transducer for Real-time Monitoring Contractile Behavior of Cardiomyocytes

In this paper, we present an intelligent piezoelectric transducer that can automatically monitor the contractile behavior of cardiomyocytes for the application of drug screening. By integrating a biomimetic substrate and a piezoelectric smart...

Authors: Hsu1 YH, Shen JW, Lin YH

SST Peer Reviewed

The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage

Mus81-Mms4/EME1 is a DNA structure-selective endonuclease that cleaves joint DNA molecules that form during homologous recombination in mitotic and meiotic cells. Here, we demonstrate by kinetic analysis using physically tethered DNA substrates that...

Authors: Mukherjee S, Wright WD1, Ehmsen KT1, Heyer WD2.

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.

Prialt, a synthetic version of Cav2.2 antagonist ?-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain. However, due to the narrow therapeutic window and...

Authors: Patel R, Rutten K, Valdor M, Schiene K, Wigge S, Schunk S, Damann N, Christoph T, Dickenson AH3

SST Peer Reviewed

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Administrations of peripheral blood CD34-positive cells contribute to medial collateral ligament healing via vasculogenesis.

Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells.

Fast and Efficient Neural Conversion of Human Hematopoietic Cells

Simplified proteomics approach to discover protein-ligand interactions

Antenatal glucocorticoid therapy accelerates ATP production with creatine kinase increase in the growth-enhanced fetal rat heart

A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem (iPS) cells

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress

A Polymer-based Piezoelectric Transducer for Real-time Monitoring Contractile Behavior of Cardiomyocytes

The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.